Facility

X-Ray Crystallography

Determining the atomic three dimensional structures of large biological molecules, to link protein structure with function and rational drug design.

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Address

School of Life Sciences

University of Dundee 
Dow Street 
Dundee

DD1 5EH

Campus

City Campus

Group or department

School of Life Sciences

Available for external users

Please get in touch if you would like to discuss your project with us

The X-ray Crystallography Facility provides instrumentation and expertise to help researchers crystallize biological macromolecules and determine their three-dimensional structures by X-ray crystallography.  To aid crystallisation we have access to Mosquito and Oryx nanolitre crystallisation robots alongside dedicated incubation and imaging equipment. Diffraction analysis can be performed using our in-house Rigaku Micromax 007HF-M X-ray generator equipped with a Rigaku Saturn 944+ CCD detector. Access is also available at both Diamond and the ESRF synchrotrons via a group BAG allocation. 

Equipment and facilities list 

  • Rigaku M007HF X-ray generator equipped with Varimax Cu-VHF optics, a Saturn 944HG+ CCD detector and an AFC-11 4-axis partial χ goniometer.  An Oxford Cryosystems Cobra provides cooling at the sample position. 
  • Access to a Douglas Instruments Oryx dispensing robot capable of 100nl drops 
  • Access to Art Robbins Scorpion for robotic generation of crystal optimisation screens 
  • Semi-Automated crystal soaking and harvesting facility to increase the throughput of compound screening campaigns 

Supporting your research

If you’d like to find out more about how we can support your research, please get in touch to discuss your project further. 

All work with external clients is undertaken in accordance with our standard Terms & Conditions.  

Enquiries

Dr Paul Fyfe

Scientific Officer

+44 (0)1382 385096

p.k.fyfe@dundee.ac.uk
Facility type Research facility