Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU)

We study how eukaryotic cell biology is shaped by protein phosphorylation and ubiquitylation. Driven by our curiosity and passion to understand living creatures, our work aims to change lives by helping to cure human disease.

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The MRC Protein Phosphorylation and Ubiquitylation Unit (PPU) is  a major research centre that focuses on the understanding of the biological roles of  phosphorylation and ubiquitylation and how disruption of these processes cause human diseases such as neurodegeneration, cancer, hypertension and immune disorders.

The ultimate goal of the Unit’s research programmes is to help develop new improved strategies to treat disease. The MRC-PPU operates as a focal point between life scientists, pharmaceutical companies and clinicians to ensure that we make a critical contribution to medical research, together reaching a deeper understanding of disease.


Portrait photograph of Dario Alessi
View Professor Dario Alessi


Science Director (MRC), Professor of Signal Transduction

Professor Alessi is a biochemical engineer whose research focuses on opening up our understanding of human health and disease. Much of his current work focuses on understanding a gene involved in Parkinson’s called LRRK2 and aims to exploit findings on this to develop improved ways to better diagnose and treat the disease.

+44 (0)1382 388058

General Manager

Academic staff

Independent Investigator


Key contacts

Name Role Email
Allison Bridges Lab Manager
Helen Currie Administrator
Dr Paul Davies MRC-PPU General Manager
Alison Hart Senior Administrator
Ross Grant Lab Management Support Technician
Michele Liney Lab Manager
Emma Floyd Administrator
Aino Vainikka-Hirons Lab Management Support Technician
John Scott Lab Management Support Technician


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