School of Business
1 - 3 Perth Road
Dundee
DD1 4HG

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University of Dundee
7 - 13 Well Road
Dundee
DD1 5HL

Host: Dr Linda Sinclair

Venue: Sir Kenneth & Lady Noreen Murray Seminar Room, CTIR 2.84

Abstract 

It has been well documented that age significantly impacts the T cell compartment. Due to their highly proliferative nature, CD8+ T cells are particularly vulnerable to the effects of ageing and show a high degree of compartmental heterogeneity. Immunosenescence is a progressively degenerative state which leads to the loss of replicative capacity, initiated by a DNA damage response induced by telomere shortening. However, metabolic stressors also induce senescence, with changes in mitochondrial dynamics and metabolism better defining the heterogeneity of immunosenescence. This talk aims to show the role of mitochondrial dysfunction as an important driver of immunosenescence and the control of the inflammatory state that accompanies senescence. 

Host: Professor Mike Ferguson

Venue: MSI Large Lecture Theatre, SLS

Abstract:

Cytokinesis in many eukaryotes requires a force generating contractile actomyosin ring (CAR).  Work carried in my group over ~ three decades, using Schizosaccharomyces pombe, which we established as a model for uncovering mechanisms of eukaryotic cytokinesis, has led to the identification of components of the CAR and elucidated mechanisms of how they assemble into a contractile apparatus, how and when they constrict, and how constriction is coupled with assembly of new membranes and division septum. In the recent years, we have been investigating the precise mechanisms of force generation using a combination of advanced imaging, genetics, biophysics, and structural biology.  I will describe the recent work from the group, placing them in the broader context of the field of eukaryotic cytokinesis.

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