Hosts: Prof Angus Lamond & Prof Nicola Ternette

Venue: MSI Small Lecture Theatre, SLS

Biography - Alexander Makarov obtained his PhD from the Moscow Engineering Physics institute in 1992. In 1996 he embarked on pioneering work on the Orbitrap mass analyser at HD Technologies Ltd, a small company based in Manchester, UK. After its acquisition by Thermo Electron in 2000, Alexander spearheaded development of the Orbitrap analyser from first prototypes to the commercial launch of the LTQ Orbitrap instrument in 2005. Under his guidance, the Orbitrap technology expanded to encompass five major families of commercial instruments. He also provided scientific leadership of the Astral analyser development and technologies for high-mass analysis. His awards include the Award for Distinguished Contribution in Mass Spectrometry from ASMS, the Aston medal by BMSS and the Thomson medal from IMSF. Presently, he is Director of Research at the Life Science Mass Spectrometry Business Unit of Thermo Fisher Scientific in Bremen, Germany and a Fellow of the Royal Society in the UK.

Host: Jason Swedlow

Venue: MSI Small Lecture Theatre, SLS

Abstract 

Cell imaging has entered the “big data” era with high content and multidimensional data sets encapsulating complex and dynamic patterns that are inaccessible by human visual observation. Computation, traditionally used to quantitatively test specific hypotheses, must now also enable iterative hypothesis generation and testing by deciphering hidden biologically meaningful patterns in complex, dynamic or high-dimensional cell image data. In this talk, I will present computation-first data-driven approaches to derive new insight and/or generate new hypotheses from cell image data. I will demonstrate the potential of these methods toward application such as modelling intracellular organization, muscle fiber formation, multicellular organization and information processing, and in vitro fertilization.