Professor Tomoyuki Tanaka
Molecular Cell and Developmental Biology, School of Life Sciences
Professor Tomo Tanaka is a research scientist and group leader. He has been studying mechanisms of chromosome segregation in mitosis, chromosome organisation in the nucleus, and how errors in these processes lead to diseases. He has been a member of the European Molecular Biology Organisation (2008-), a Fellow of the Royal Society of Edinburgh (2009-), and a Wellcome Trust Investigator (2020-). In the University, he serves as the Academic Lead of Dundee Imaging Facility (2018-) and Deputy Head of the Division for Molecular Cell & Developmental Biology (2022-).
To maintain genetic integrity, a whole set of chromosomes must be inherited by daughter cells when cell division occurs. This process relies on chromosome segregation in mitosis. Errors in chromosome segregation would cause cell death and various human diseases such as congenital disorders and cancers. The research in his group focuses on two major events in early mitosis, by which chromosomes become prepared for segregation– first, chromosome re-organization involving resolution and compaction of sister chromatids; second, interactions between chromosomes and the mitotic spindle, which provide forces for chromosome segregation later in mitosis. His research aims to reveal fundamental mechanisms ensuring chromosome segregation and thus to understand the mechanisms of relevant human diseases. Please find more details of his research at https://tomotanakalab.weebly.com/research-projects.html
People in my Lab
Please find people in his group at https://tomotanakalab.weebly.com/lab-members.html
- Doodhi H., Kasciukovic T., Clayton L. & Tanaka T.U. Aurora B switches relative strength of kinetochore–microtubule attachment modes for error correction. J. Cell Biol. 220, e202011117 (2021). PMID 33851957
- Booth AJR., Yue, Z, Eykelenboom JK, Luxton GWG, Hochegger H & Tanaka TU Contractile actomyosin network on nuclear envelope remnants positions chromosomes for mitosis. eLife 8, e46902 (2019). PMID 31264963
- García-Rodríguez LJ, Kasciukovic T,* Denninger V.* & Tanaka TU. Aurora B-INCENP localization at centromeres/inner kinetochores is essential for chromosome bi-orientation in budding yeast. (* equal contribution) Curr Biol, 29, 1536-44 (2019). PMID 31006596
- Eykelenboom, J.K., Gierlinski, M.*, Yue, Z.*, Hegarat, N.*, Pollard, H., Fukagawa, T., Hochegger, H., & Tanaka, T.U. Live imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosis. (* equal contribution) J. Cell Biol. 218, 1531-52 (2019). PMID 30858191
- Li S, Yue Z & Tanaka TU. Smc3 deacetylation by Hos1 facilitates efficient dissolution of sister chromatid cohesion during early anaphase. Mol Cell. 68, 605-14 (2017) PMID 29100057
- Vasileva V, Gierlinski M, Yue Z, O’Reilly N, Kitamura E & Tanaka TU. Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules. J. Cell Biol, 216, 1609-22 (2017). PMID 28446512
- Kobayashi N, Suzuki Y, Schoenfeld LW, Müller CA, Nieduszynski C, Wolfe KH & Tanaka TU. Discovery of an unconventional centromere in budding yeast redefines evolution of point centromeres. Curr Biol, 25, 2026-33. (2015). PMID 26166782
- Kalantzaki M, Kitamura E, Zhang T, Mino A, Novák B & Tanaka TU. Kinetochore–microtubule error correction is driven by differentially regulated interaction modes. Nat Cell Biol, 17, 421-33, (2015). PMID 25751138
Please find a full list of publications at https://tomotanakalab.weebly.com/publication.html
A) Lectures and tutorials for undergraduate students about chromosome segregation in mitosis - Level 3 (BS31006 Gene Regulation and Expression)
B) Supervisor of Honours degree students - Lab-based projects and literature/data analysis projects
C) Supervisor of PhD students
Researchers at the University of Dundee have discovered novel mechanisms for chromosome inheritance by recreating this process in a test tube.
Professors Vicky Cowling and Tomo Tanaka were given Investigator Awards from Wellcome in the recent funding round.
The research group led by Professor Tomo Tanaka has made a significant new discovery about how cells properly inherit their genetic information.
Mechanisms ensuring proper chromosome segregation in mitosis
|Major Personal Funding Awards / Wellcome Investigator Award||2020|
|Major Personal Funding Awards / European Research Council Advanced Grant||2013|
|Personal Fellowships / Wellcome Trust Principal Research Fellowship||2012|
|Fellow of the Royal Society of Edinburgh||2009|
|Member of the European Molecular Biology Organisation||2008|
|National Sciences Prizes awarded since 1990 / The Hooke Medal of the British Society for Cell Biology||2007|
|Personal Fellowships / Cancer Research UK Senior Cancer Research Fellowship||2007|
|National Sciences Prizes awarded since 1990 / Lister Research Prize Fellowship||2005|
|Personal Fellowships / Lister Institute Research Prize Fellowship||2005|
|International Science Prizes awarded since 1990 / EMBO Young Investigator||2000|
I am available for media commentary on my research.
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Areas of Expertise