Molecular Cell and Developmental Biology
The Division of Molecular, Cell and Developmental Biology (MCDB) consists of research groups with interests in molecular biology, cell biology, and developmental biology.
The central dogma of molecular biology relates to the flow of genetic information from DNA (the storage site) to RNA (the messenger), which in turn acts as a template for protein synthesis. These fundamental processes are regulated precisely in cells that form building blocks of tissues within our bodies. They underpin differences in cells of different tissue types and are altered in disease.
Research in the division therefore spans biology at different scales from molecules to cells and tissues and explores relevance across these levels to human diseases. Our activities include exploring the molecular basis of genetic programs (DNA replication, transcription, epigenetics, splicing and translation); understanding the mechanisms of sub-cellular organisation and dynamics (chromosome inheritance, cell polarity, membrane traffic) and revealing the principles of cellular differentiation and how tissues and organs are formed.
To facilitate our research, we have established shared resources for advanced technologies including Microscopy, Human Pluripotent Cell culture, Proteomics, and High Content screening. We find that collaboration is an effective and enjoyable way of working across scales and facilitating the translation of our discoveries.
Facilities within the School of Life Sciences that are led by principal investigators within MCDB:
Cells need to be able to control the localization of their content to fulfil specific functions.
Maintenance of tissues requires a delicate balance between a number of processes such as the increase in the number of cells (proliferation) and the type of cells they become (differentiation).
New work from Professor Kate Storey’s laboratory has recently been published in eLife.
Two University of Dundee scientists have been awarded prestigious fellowships.