Professor Kate Storey
FMedSci FRS FRSE FRSB
Molecular Cell and Developmental Biology, School of Life Sciences
Researchers in Kate Storey’s laboratory investigate how the nervous system forms during embryonic development.
We all come from a single cell, the fertilised egg. As this cell divides to generate the embryo individual cells begin to specialise in a process known as cellular differentiation. We wish to understand how neural cells arise in the embryo and how their differentiation is controlled.
The spinal cord is generated progressively as the embryonic body is laid down and this helps us to identify and investigate the distinct steps that underlie its formation. These include when and how neural precursor cells stop dividing and become nerve cells, and how these cells then change shape and ultimately make connections to form functional neural circuitry.
Our team uses a wide range of techniques, including gain and loss of gene function approaches and genome-wide analyses, as well as live imaging assays, which allow us to monitor changes in cell behaviour during differentiation.
Our overall aim is to discover cellular and molecular mechanisms that control neural differentiation. Elucidating these mechanisms helps us to understand better how the developing nervous system is impacted by cellular stress and may inform strategies for therapeutic treatment of neural injury and disease.
People in My Lab
- Dr Lindsay Davidson
- Ms Elisenda Raga Gil
- Dr Aida Rodrigo Albors
- Ms Sophie Rappich (Co-supervision with Dr Greg Findlay)
- Ms Ines Jmel Boyer (Co-supervision with Dr Januschke)
- Ms Amy Dunne Miller (Co-supervision with Dr Sourav Banerjee)
A complete publication list can be found using my ORCID 0000-0003-3506-1287
Kasioulis I., Dady, A., James, J., Prescott, A., Halley, P.A., and Storey K.G., A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis. J Cell Sci. 2022 Feb 25: jcs.259897. doi: 10.1242/jcs.259897. PMID: 35217862 Read Article
Dady, A., Davidson, L., Halley, P.A, Storey, K.G., Human spinal cord differentiation proceeds rapidly in vitro and only initially maintains differentiation pace in a heterologous environment. eLife. 2022 Feb 21;11:e67283. doi: 10.7554/eLife.67283. PMID: 35188104 Read Article
Poncet N., Halley P.A., Lipina C., Gierliński M., Dady A., Singer G.A., Febrer M., Shi Y.B., Yamaguchi T.P., Taylor P.M., Storey, K.G., (2020) Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos. EMBO Reports 21(1) doi/10.15252/embr.201948469 PMCID 6944906 PMID 31789450 Read Article
Rodrigo Albors, A., Halley, P., Storey, K.G., (2018) Lineage tracing of axial progenitors using Nkx1-2CreERT2 mice defines their trunk and tail contributions. Development, 2018 145: dev164319. doi/10.1242/dev.164319 PMCID 6198475 PMID 30201686 Read Article
Verrier, L., Davidson, L., Gierlinski, M., Dady, A., Storey, K.G., (2018) Neural differentiation, selection and transcriptomic profiling of human neuromesodermal progenitors-like cells in vitro. Development, 145(11). doi/10.1242/dev.166215 PMCID 6124542 PMID 29899136 Read Article
Kasioulis, I., Das, R. M., Storey, K.G., (2017) Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination. eLife. doi/10.7554/eLife.26215 PMCID 5653239 PMID 29058679 Read Article
Olivera-Martinez, I., Schurch, N., Li, R., Song, J., Halley, P.A., Das, R.M., Burt, D.W., Barton, G.J., Storey, K.G., (2014) Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development, 141: 3266-3276 doi/10.1242/dev.112623 PMCID 4197544 PMID 25063452 Read Article
Das, R. M., Storey, K.G., (2014) Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis. Science. 343, 200-204. doi/10.1126/science.1247521 PMCID 4066580 PMID 24408437 Read Article
Patel, N.S., Rhinn, M., Semprich, C.I., Halley, P.A., Dolle, P., Bickmore, W.A. and Storey, K.G., (2013) FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription. PLoS Genetics. 9, e1003614. doi/10.1371/journal.pgen.1003614 PMCID 3715432 PMID 23874217 Read Article
Olivera-Martinez, I., Harada, H., Halley, P.A., Storey, K.G., (2012) Loss of FGF-dependent mesoderm identity and rise of endogenous retinoid signalling determine cessation of body axis elongation. PLoS Biology. 10, e1001415. doi/10.1371/journal.pbio.1001415 PMCID 3484059 PMID 23118616 Read Article
Contributes lectures to:
- Stem Cells in Development and Disease – year 4
- Cell Biology of Disease – MSc Res
- Graduate student super-seminars – x2
and supervision for:
- Honours student projects – 10-week projects x2
- Rotation projects – 3-month rotations
- Graduate student supervision
Kate Storey is stepping down from co-leadership of the Division of Molecular, Cell and Developmental Biology (MCDB). Jens Januschke will join Tom Owen-Hughes as joint divisional lead.
An international collaboration led by scientists at the University of Dundee has discovered one potential roadblock to spinal cord regeneration in humans.
Professor Kate Storey, of the University of Dundee, has been elected a Fellow of the Royal Society (FRS), the world's oldest scientific academy in continuous existence.
Mechanisms of neural differentiation
|Fellow of the Royal Society||2022|
|National Sciences Prizes awarded since 1990 / British Society for Developmental Biology Waddington Medal||2019|
|Fellow of the Academy of Medical Sciences||2017|
|Member of the European Molecular Biology Organisation||2016|
|National Sciences Prizes awarded since 1990 / Royal Society Wolfson Research Merit Award||2015|
|Major Personal Funding Awards / Wellcome Trust Senior Investigator Award||2013|
|Fellow of the Royal Society of Edinburgh||2012|
|Fellow of Learned Societies and Colleges / Fellow of the Royal Society of Arts||2011|
|Fellow of the Royal Society of Biology||2011|