The molecular pathogenesis of Huntington’s disease and development of Huntingtin bioassays for preclinical therapeutic applications.”
Host: Prof Angus Lamond
Venue: MSI Small Lecture Theatre, SLS
Speaker Bio - Dr. Christian Landles is a Senior Research Fellow at the Bates lab, part of the Department of Neurodegenerative Disease, Huntington’s Disease Centre, Queen Square Institute of Neurology, University College London, London, UK. He obtained his PhD from Cancer Research UK and has held numerous research positions at various renowned academic institutes, including King’s College London, Imperial College London, and UCL. He has more than a decade of research experience resulting in over 50 publication contributions and has worked on studies funded by the CHDI Foundation and UK Dementia Research Institute. His area of expertise includes the molecular pathogenesis, pre-clinical mouse models, and the protein biology and aggregation of Huntington's disease. In addition to researching Huntington's disease, he has extensive experience in technology and molecular assay development with translational applicability for biomarker discovery and therapeutics.
Long interfacial gravity wave-induced short-wave instabilities
In two-layered density stratified geophysical flows, the shear produced by long interfacial gravity waves can render short waves unstable. The two-layered oscillating tank configuration considered in this study provides a simplified analogue of the realistic setting. We show that the equation governing the evolution of linear perturbations on the density interface is a Schrödinger-type ODE with a periodic potential. A single nondimensional parameter β governs the stability condition, and instability arises when β>1/4. When this instability condition is satisfied, the flow is still stable for an initial period but finally tunnels into the unstable region after reaching the time marking the turning point. We also provide a comparison with actual oceanographic settings to obtain a physical perspective of the key parameters.
Venue: Fulton Building, Room G20