Retrieval of ubiquitinated proteins from cilia

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Research

Host: Yogesh Kulathu

Venue: MSI Small Lecture Theatre, SLS


This seminar is fully funded by external sources

Abstract:

Cilia are cell-surface organelles crucial for various signal transduction pathways and the spatial distribution of proteins within cilia is dynamically regulated by the intraflagellar transport (IFT) machinery. K63-linked polyubiquitination has been linked to the IFT-mediated retrieval of proteins from cilia, however, the mechanisms by which polyubiquitinated proteins are recognized for export remain unclear. Here, I present my work identifying that CFAP36, a highly conserved ciliary protein of previously unknown function, binds polyubiquitinated proteins and links them specifically to retrograde IFT trains. In addition, ARL3, a small GTPase known primarily for its role as a cargo displacement factor, functions as a cargo loading factor for retrograde transport, enhancing the binding of polyubiquitinated cargos by CFAP36

Bio:

Following training in structural biology at the Max-Planck institute in Dortmund, Germany, Sven obtained his Ph.D. with Sir Philip Cohen at the MRC PPU in 2020, where he worked on the allosteric regulation of protein kinases through pseudokinases. Next, during postdoctoral training with Yogesh Kulathu, also at the MRC PPU, he worked on branched ubiquitin chains and deubiquitinases. In 2022, Sven joined the Brown lab at Harvard Medical School to investigate how ubiquitinated proteins are retrieved from cilia, for which he was awarded a Sara Elizabeth O'Brien Trust Postdoc Fellowship in 2023. Outside the lab, Sven applies his biochemistry skills to working with yeast for brewing and bread baking, and enjoys hiking in the New England mountains.


 

 

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MRC Protein Phosphorylation and Ubiquitylation Alumni Seminar by Sven Lange, Harvard Medical School
Staff United Kingdom

Reuter in Tehran

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title slide - reuter in tehran
Artists' image. Close up of 'Baron Reuter Travelling from the Past' his 19th C portrait atop a drawing of a ufo. Saving world news in a nutshell
Design and Art

Bahar Noorizadeh and her collaborator, Glasgow based Yemeni sound artist Intibint invite us to a sound performance developed from Noorizadeh’s installation Reuter in Tehran.

A staging of investigative research, delirious diagrams, secret dossiers and weird cartographies, Reuter in Tehran traces the footprints of a peculiar organism that has survived through Iran’s economic system, since the founding of the first modern bank in Iran — the Imperial Bank of Persia — in 1889. The work travels through the free economic zones stretched across the Southern coast to narrate an occult history of pseudo-financial institutions, subcontractor empires, and the labyrinth of shadow banks that has seized Iran to the present. Traversing through centuries — of financial promises and exchange — Reuter in Tehran offers an alternative cosmology of capital. What’s behind Money? All of History.
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Co-curated with Bahar Noorizadeh, part of Weird Economies x Scotland programmed alongside Noorizadeh's exhibition at Cooper Gallery, The Debtor's Portal.

Tickets

Book free tickets to the performance via Eventbrite

Free
Artists' image. Close up of 'Baron Reuter Travelling from the Past' his 19th C portrait atop a drawing of a ufo. Saving world news in a nutshell

Biographies

Intibint is a producer, singer-songwriter, visual artist and DJ, born and raised between the UK and Yemen. Her music is primarily electronic, embedded with inspiration from Yemeni sounds, exploring themes that straddle both the personal and the collective. Her live performances infuse layered vocals, field recordings, as well as both original productions and covers of songs from the Arab region and beyond. Across sound, visuals, and performance, whether producing original music, curating a dancefloor, or through her work as the founder of @al.yamaniah, Intibint’s practice is rooted in resistance and reclamation.

Bahar Noorizadeh’s work looks at the relationship between art and capitalism, and their entangled moral, social and organisational technologies. In her practice as an artist, theorist and filmmaker, she examines the conflictual and contradictory notions of imagination and speculation as they collapse into one another. Her research investigates the histories and the futures of economics, from cybernetic socialism to neoliberal finance, and activist strategies against the financialization of life and the living space, asking what redistributive historical justice might look like for the present. 

Noorizadeh is the founder and organiser of Weird Economies, a multi-authored platform dedicated to radical economic imaginaries. Her work has appeared at the Guggenheim Museum NYC (2024), Taipei Biennial (2023), Venice Architecture Biennial (2021), Transmediale Festival (2020, 2022), Tate Modern Artists’ Cinema Program (2018), and Geneva Biennale of Moving Images (2018) among others. She is the co-editor of the e-flux special issue on Iran (May 2024) and has contributed essays to e-flux Architecture, Journal of Visual Culture, and Sternberg Press, and anthologies by Duke University Press and MIT Press. Noorizadeh completed a PhD in Art at Goldsmiths, University of London and is currently teaching in MA Geo-Design at the Design Academy Eindhoven.

www.baharnoorizadeh.com

Access

Cooper Gallery is located to the right side of the DJCAD buildings on Perth Road. The entrance is via double doors which face onto a car park.

The gallery is on two floors. Ground floor has ramped access. First floor is accessible by an internal lift and six steps with a handrail. Wheelchair access is via a stairclimber. Please email in advance if you require lift or stairclimber access.

First floor is also accessible via 24 steps. Two flights of 12 steps with handrails are separated by a landing.

The performance will take place on the second floor of the gallery.

Exhibition video is captioned in English. Audio will be played aloud via speakers. Seating is provided and/or additional seating available, please ask an invigilator. 

For all enquiries please email: [email protected]

Toilets

The ground floor has a wheelchair accessible toilet. The toilet is gender neutral.

Interpretation

Large print versions of the exhibition information handout are available, please ask our Guides. If you require alternative formats for material in exhibitions please email or ask our Guides.

Image Credit

Bahar Noorizadeh, Hayek in Iran, 2026 (detail)
Printed map on fabric. Photo by Sally Jubb.

Funding support

The exhibition is supported by the National Lottery through Creative Scotland and with the kind support of Duncan of Jordanstone College of Art Centenary Trust. The Otolith Collective is supported using public funding by Arts Council England. 

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Cooper Gallery
Cooper Gallery Cooper Gallery Bahar Noorizadeh: The Debtor’s Portal Weird Economies x Scotland
Book free tickets via Eventbrite
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Live Performance by Intibint and Bahar Noorizadeh (In-person)
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