Hosts: Dr Tony Ly & Dr Alejandro Brenes Murillo

Venue: MSI Small Lecture Theatre, SLS

Abstract: Altered metabolism is a hallmark of cancer and metabolic alterations can be found both in the tumour and systemically. The overarching goal of our research is to exploit these metabolic alterations to design better treatments by targeting the tumour microenvironment, and to identify biomarkers of early disease.

Elevated production of tumour extracellular matrix (ECM) is a hallmark of cancer-associated fibroblasts (CAFs) and a central driver of cancer aggressiveness and immunosuppression. We have identified specific metabolic pathways highly active in CAFs in aggressive breast tumours. I will discuss how these metabolic pathways support elevated production of tumour ECM and the impact of targeting them to oppose cancer by creating an anti-tumour, immuno-active tumour microenvironment.

I will also discuss MS proteomic methods that we have developed to study oxidative signalling dynamics and their development for biomarker discovery.

The British Society for Proteome Research (BSPR) is the UK’s national proteomics society, part of the European Proteomics Association. The society’s objectives are to advance the science of proteomics and to promote the study and research work in this and related areas for the benefit of all. Student membership to the BSPR is free for the duration of the study period. 

 Every year the BSPR selects a prominent researcher to be named the BSPR lecturer. Their objective is to promote proteomics within the UK by sharing their research and promoting the BSPR. This year the BSPR lecturer is Prof. Sara Zanivan from the CRUK Scotland Institute, where she leads a group focussed on studying the tumour microenvironment with emphasis on cancer associated fibroblasts.

Speaker: Professor Yiannis Karavias  (Brunel University London)

Host: Dr Sisi Sung

This paper develops a new toolbox for multiple structural break detection in panel data models with interactive effects. The toolbox includes tests for the presence of structural breaks, a break date estimator, and a break date confidence interval. The new toolbox is applied to a large panel of US banks for a period characterized by massive quantitative easing programs aimed at lessening the impact of the global financial crisis and the COVID-19 pandemic. The question we ask is: Have these programs been successful in spurring bank lending in the US economy? The short answer turns out to be: "No".

Read the full paper on the Cornell University website

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Morning session

11:30-12:30 - “How organisational science can collaborate productively with natural science” (by Prof. Jan Bebbington, Lancaster University Management School)

• On campus: Dalhousie Building, room 2S13  
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Afternoon session

14:00-15:30 - “Accounting, calculation, and accountability: the case of nonfinancial reporting benchmarks" (by Dasha Smirnow, Jan Bebbington and Bertrand Charron)

• On campus: Dalhousie Building, room 2G12
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Third party benchmarking of nonfinancial reporting is a feature of organisational life that builds upon other forms of comparative evaluation of corporate data. Benchmarking of nonfinancial reporting, however, has not attracted widespread attention in the accounting literature even though it is a potential mechanism for enhancing transparency and accountability for reporting on grand challenges. This paper addresses this gap by exploring benchmarking through a two-stage investigation. A sample of nonfinancial benchmarks are presented and characterised before the paper moves to an in-depth examination of the operation of a benchmark that ranked global salmon producers from 2011 until 2017. Through working with the producer of the benchmark, the paper illuminates how the benchmark was constructed and the decisions that are made in this area of practice. In addition, the impact of the benchmark on reporting quality over time is examined. Understanding what happens inside the ‘black box’ of benchmarking provides the basis from which we draw methodological insights into the world of practice with the aim of enhancing our understanding how benchmarking impacts corporate accountability.

Host: Dr. Stavros Kourtzidis
 

Host
Dr. Sisi Sung)
Speaker
Dr. Deborah Gefang
(University of Leicester)

Details to follow

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