Current Trials at TCTU

A multicentre, UK wide RCT investigating the use of long-term antibiotics versus short term antibiotics to prevent permanent Pseudomonas infections in patients with Bronchiectasis.

This study is part of a major programme of research, called the Advanced Pain Discovery Platform - APDP. The programme is looking to understand the causes of chronic pain and improve the lives of people who have pain conditions. Recruiting

This study is part of a major programme of research, called the Advanced Pain Discovery Platform - APDP. The programme is looking to understand the causes of chronic pain and improve the lives of people who have pain conditions. Recruiting

A multicentre, 3 arms feasibility trial to compare 2 regimes of total neoadjuvant therapy (TNT) versus standard care in patients with newly diagnosed oesophageal adenocarcinoma

This aim of this trial is to identify biomarkers that predict responses to different antihypertensive treatment. Funded by EU Horizon, the trial is recruiting in Nijmegen and Zurich. Trial design is an incomplete, randomised, controlled cross over, with 3 treatment periods and 4 treatment arms.

Developing strategies for Hepatitis C in Ethiopia. Ongoing

The SOPHIST trial studies the effect of the drug, Sotagliflozin, on the quality of life of individuals with Heart Failure and Type 1 Diabetes. Recruiting

This is an unblinded platform trial, investigating different anti-inflammatories for the treatment of bronchiectasis. This is part of the EMBARC research network. Recruiting

The TAYCAN trial investigates the development of a genetic blood test for patients with pancreatic or bowel cancer. In set up

Safety and efficacy trial of MRI guided focussed ultrasound (MRgFUS) to treat the brain cells damaged by Parkinson’s Disease. Single site study in NHS Tayside, treating UK participants by referral. Recruitment target of 10 patients over 2 years. Recruiting

A multi-site feasibility study to determine if patient derived organoids can be grown in the laboratory from tumour biopsies taken from patients with oesophageal squamous cell cancer (OSCC). This could potentially lead to the first Western biorepository of this nature. In set-up