Completed Trials at TCTU
We have highlighted some of our completed trials, to demonstrate breadth of disciplines TCTU has worked across and the range of support TCTU can provide.
| Name | Description | Further information |
|---|---|---|
| PROTEAN | Proteomic Profiling of Oesophageal and Gastroesophageal Junction Adenocarcinoma Neoantigens | |
| INFLUENCE | A prospective randomised study comparing indocyanine green (ICG) fluorescence combined with a standard tracer versus ICG alone for sentinel lymph node (SLN) detection in early breast cancer. | INFLUENCE trial information |
| PIVUC | A two-stage preliminary investigation of the visual and histological changes to healthy volunteer skin from single and repetitive exposure to virucidal Krypton-Chloride (KrCl) Far-UVC-emitting excimer lamps. | PIVUC trial information |
| INCOGNITO | INvestigating COPD Outcomes, Genomics and Neutrophilic Inflammation with Tiotropium and Olodaterol. | INCOGNITO trial information |
| MUSIC | Investigating the mechanism of inhaled corticosteroids associated pneumonia by longitudinal characterisation of the airway microbiome in patients with severe COPD. | MUSIC trial information |
| ArchWire RaCE | A randomised clinical trial which aims to compare the clinical effectiveness of FireWire archwires to Copper Nickel Titanium (CNiTi) archwires. | ArchWire RaCE trial information |
| STOP COVID-19 | Research to test the effectiveness of a new anti-inflammatory drug, Brensocatib, to improve symptoms and reduce hospitalisation for people with COVID-19. | STOP COVID-19 trial information |
| REACH | Testing and treating people receiving methadone for Hepatitis C in community pharmacies. | REACH trial information |
| ADVANCE | Investigating the best way to provide treatment for people who inject drugs infected with Hepatitis C virus. | ADVANCE trial information |
| SUSSED | Understanding barriers to increasing physical activity in chronic pain. | SUSSED trial information |
| LACE | Leucine and ACE inhibitors as therapies for sarcopenia: a two by two factorial randomised placebo-controlled trial. | LACE trial information |
| MULTIPROS | Assessing the readability of pre-biopsy MRI in correctly predicting the grade and aggressiveness of prostate cancer in 600 men. | MULTIPROS trial information |
| RAINDroP | Randomised controlled pilot to identify people with iron deficiency who do not respond to oral iron supplementation. | RAINDroP trial information |
| ERADICATE Hep C | Eradicate Hepatitis C Virus: A pilot of treatment as prevention in active drug users. | ERADICATE Hep C trial information |
| SuperDOT-C | Pharmacy-led HCV therapy versus conventional treatment pathways for HCV positive patients receiving daily OST. | SuperDOT-C trial information |
| ECLS Study | The largest randomised trial conducted using biomarkers for the early detection of lung cancer, in over 12,000 Scottish high-risk smokers. | ECLS study information |
| BiCARB | Assessing the efficacy of sodium bicarbonate in 300 older people with chronic kidney disease. | BiCARB trial information |
| MTAK | Microwave Therapy for the treatment of pre-cancerous Actinic Keratosis. | MTAK trial information |
| K-SWAY | Investigating Vitamin K supplementation to improve balance in older people – and reduce the risk of falls. | K-SWAY trial information |
| K4Kidneys | Investigating if Vitamin K therapy can improve vascular health in patients with Chronic Kidney Disease. | K4Kidneys trial information |
| PACT | Online trial examining if prescribing asthma controller medication according to genotype improves quality of life in young people with asthma. | PACT trial information |
| ALFIE | Investigating whether allopurinol can improve muscle strength and endurance in older people. | ALFIE trial information |
| ALTERED | Does allopurinol regress left ventricular hypertrophy in end stage renal disease? | ALTERED trial information |
iLFT |
A pilot evaluation of a synergistic liver diagnostic pathway: Making sense of LFTs for patients, GPs and the NHS in Scotland. Intelligent Liver Function Testing.
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| ADDUCE | Large European Union trial studying the long-term safety in ADHD treatment. | ADDUCE trial information |
| STAKT | Investigate the short term effects of an AKT inhibitor on breast cancer. | STAKT trial information |
| OPTIMISTIC | Evaluate the effect of a tailored behavioural change intervention comprising CBT and graded exercise on participation (as measured by the DM1-Activ scale) for severely fatigued patients with myotonic dystrophy type 1 compared to standard care. | OPTIMISTIC trial information |
| PREFACE | Evaluate the effect of a tailored behavioural change intervention comprising CBT and graded exercise on participation (as measured by the DM1-Activ scale) for severely fatigued patients with myotonic dystrophy type 1 compared to standard care. | PREFACE trial information |
| AMBER | Investigating whether abdominal massage can help improve the symptoms of neurogenic bowel dysfunction in people with multiple sclerosis. | AMBER trial information |
| adAPT | Investigating whether metformin, that is known to reduce insulin demand in type 2 diabetes (T2D), can do the same in children at risk of type 1 diabetes. | adAPT trial information |
| ALLAY | British Heart Foundation trial investigating whether allopurinol can regress left ventricular hypertrophy in patients with treated essential hypertension. | ALLAY trial information |
| ViaDUCT | Investigating if Vitamin D supplementation can improve Hepatitis C cure rates. | ViaDUCT trial information |
| REFORM | Research into the effects of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus. | REFORM trial information |
| ALPHA | British Heart Foundation trial investigating if allopurinol can reduce right ventricular mass in lung disease associated pulmonary hypertension. | ALPHA trial information |
| HAP | What is the most effective method for providing orthodontic anchorage? A randomised clinical trial of Headgear, AbsoAnchor mini-screws, and palatal arch. | HAP trial information |
| ACES | Can an arts based creative engagement intervention following stroke improve psychosocial outcomes? | ACES trial information |
| FFIT | A gender-sensitive weight loss and healthy living programme delivered to men aged 35-65 by Scottish Premier League (SPL) football clubs. | FFIT trial information |
| PIRFECT | A podiatry intervention to reduce falls in care home residents. | PIRFECT trial information |
| SPIR-OA | The effect of spironolactone on pain in older people with osteoarthritis. | SPIR-OA trial information |
| VESUVIUS | Vascular effects of regular cigarettes versus electronic cigarette use. | VESUVIUS trial information |
| GOAL | Can eliciting and addressing health-related goals improve asthma control and asthma-related quality of life? | GOAL trial information |
| Game of Stones | A research study that texts men to help them lose weight. | Game of Stones trial information |
| SKIP-IT | Text intervention as an aid to smoking cessation in pregnant women. | SKIP-IT trial information |
| ALL ACS | Allopurinol as a possible new therapy for acute coronary syndrome. | ALL ACS trial information |
| DAPA-LVH | Does dapaglifozin regress left ventricular hypertrophy in patients with type 2 diabetes? | DAPA-LVH trial information |
| ActWELL | A randomised control trial to assess the impact of a lifestyle intervention in women invited to NHS breast screening. | ActWELL trial information |
| CUBS | Development and feasibility study to compare cue-based versus scheduled feeding for preterm infants transitioning from tube to oral feeding in neonatal units. | CUBS trial information |
| GREAT-2 | GREAT-2 is a clinical trial to test a new treatment for bronchiectasis. Full information can be found on our website. In analysis | GREAT-2 trial information |
| PNEUMO | A study to investigate how often different types of pneumonia occur in people admitted to hospital and how often an infection of a specific bacterium occurs. | |
| BATMAN | To determine if intravenous treatment with alpha-1 proteinase inhibitor reduces sputum neutrophil elastase activity in patients with bronchiectasis. | |
| Pharmacy HbA1c | Evaluation of a Community Pharmacy-Based Testing Method for People with Diabetes Compared to Standard Care Laboratory-Based Testing. | |
| VitalBE | Research to test the effectiveness of an inhaled antibiotic, Cayston, on bronchiectasis. | Vitalbe trial information |
| EraPID | Evaluation of Hepatitis C treatments in NHS Tayside in order to empirically test the 'treatment as prevention' models. | |
| EPIToPe | Evaluating the population impact of Hepatitis C direct-acting antiviral treatment as prevention for people who inject drugs. | EPIToPe trial information |
| Rescue-2 | Pneumowave have designed a wearable respiratory monitoring device. This is worn by people who use drugs (PWUD) and connected to a blue tooth ‘hub’. The hub records their breathing patterns and can be used to detect events requiring an emergency response. |