Our laboratory studies how bacteria form biofilms. We worked with the scientific animation company Vivomotion to make an animation that explains what biofilms are and how they impact our everyday lives.
The Stanley-Wall lab actively engages in outreach activities with both school age children and members of the public. Our work has been nationally by prizes from the Society for General Microbiology (2011) and the Royal Society of Edinburgh (2012).
Nicola Stanley-Wall is academic lead for Public Engagement in the School of Life Sciences. Please feel free to contact us if you would like advice about organising large microbiology outreach events via sls-PublicEngagement@dundee.ac.uk.
The ability of unicellular bacteria to co-ordinate responses and to act as a multicellular population is proposed to provide an advantage to the bacterial population as a whole. A mechanism whereby bacteria can function as a multicellular population is to form a biofilm, a community of bacterial cells that is adherent to a surface, interface or to each other and encased in a self-produced polymeric matrix.
Bacteria living in biofilms have increased resistance to various antimicrobial agents and are better adapted to survive periods of environmental stress. Therefore, biofilms have a significant impact in clinical settings, where they are the causative agent of the majority of chronic infections, and in industrial settings where they cause significant damage due to corrosion and bio fouling. On the other hand microbial biofilms can also result in beneficial processes such as bio-remediation and bio-control that cannot be accomplished by bacteria that are dispersed in the environment. Knowledge of the molecular mechanism of biofilm formation should allow the development of novel treatment strategies for controlling chronic biofilm infections and the development of ecologically friendly pesticides.
Our research interests are centred on using molecular biology and biochemistry to understand how bacterial build multicellular communities called biofilms. In particular we are interested in the way the molecules in the biofilm matrix provide support and protection to biofilms formed by the Gram-positive bacterium Bacillus subtilis. We work closely with Prof Cait MacPhee a biophysicist from the University of Edinburgh, and Profs Fordyce Davidson, Michael Ferguson and Jason Swedlow from the University of Dundee.
BS22022 – course contributor and tutorial leader
- Koch’s postulates- historical and current views.
BS32004 – “Molecular Microbiology” – module lead
- Microbial diversity
- Cell division
- Biofilm formation
- Controlling Sigma Factors
BS32011 – “Microbial Cell Biology” – module contact
- Practical unit using transposon mutagenesis of Bacillus subtilis to learn about genetics, bacterial physiology, and molecular biology.
Honours Year – annual project supervisor from 2005-current
MSci – project supervisor from 2017-current
Review of the Year 2021 took place virtually today with the former Interim Dean, Inke Näthke sharing the highlights of activity within the School from 2021
Local children are being offered a special experience over the summer holidays in the first ever Dundee Science Centre STEM summer club.
In recent weeks staff who teach on Biological and Biomedical Sciences programmes have been recognised in the DUSA Student-led teaching awards and the BBSE awards.
Understanding the molecular mechanism of biofilm formation
|PiCLS Best Mentor Award||2021|
|Fellows of Learned Societies and Colleges / Senior Fellow of the Higher Education Academy||2019|
|Fellows of the Royal Society of Edinburgh||2018|
|International Science Prizes awarded since 1990 / Fellow of the European Academy of Microbiologists||2018|
|National Sciences Prizes awarded since 1990 / Wain Medal||2016|
|National Sciences Prizes awarded since 1990 / Royal Society of Edinburgh Patrick Neil Medal||2012|
|National Sciences Prizes awarded since 1990 / Royal Society of Edinburgh Beltane Prize for Public Engagement||2012|
|Fellows of the Royal Society of Biology||2012|
|Fellows of Learned Societies and Colleges / Royal Society of Edinburgh, Young Academy||2011|
|Personal Fellowships / Fellow of the Royal Society of Edinburgh Young Academy||2010|
|National Sciences Prizes awarded since 1990 / The Fleming Award Medal of the Society for General Microbiology||2009|