Professor Mark Field
Biological Chemistry and Drug Discovery, School of Life Sciences
Parasitic disease continues to constitute a major global threat. We study fundamental aspects of parasite biology to identify new therapeutic targets for clinical intervention, focusing on the African Trypanosome, Trypanosoma brucei (the causal agent of sleeping sickness in humans and livestock in sub-Saharan Africa), and specifically macromolecular transport, signaling, gene expression and evolution. Our specific areas of research interest include: The roles of components of the endocytotic pathway in drug sensitivity, virulence in vivo and protein/lipid sorting mechanisms, understanding the contribution of the nuclear pore complex and nuclear envelope on gene expression and reconstructing the evolutionary history of intracellular transport pathways and the origins of the eukaryotic cell.
I am available for media commentary on my research.
Professor Field’s work principally exploits the parasitic protozoan Trypanosoma brucei and efforts to leverage genomics and proteomics resources to provide insight into virulence mechanisms and basic cell biology, with specific interests in protein transport systems and nuclear organisation. He has interests in bioinformatics, graphic design, functional genomics and eukaryotic evolutionary biology.
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Areas of expertise
- Antimicrobial resistance
- Infectious diseases
|Major Personal Funding Awards / Wellcome Trust Investigator Award
|Fellow of the Royal Society of Biology
Researchers at the University of Dundee have identified a new drug target in parasites that cause major neglected tropical diseases, a discovery that contributes towards a global drive to eliminate these diseases by 2030.