Professor Alessio Ciulli



Biological Chemistry and Drug Discovery, School of Life Sciences

Director of the Centre for Targeted Protein Degradation

Centre for Targeted Protein Degradation, School of Life Sciences

Alessio Ciulli
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+44 (0)1382 386230


Ciulli Lab


Research in the Ciulli Lab broadly spans the fields of Chemical Biology and Structural Biology of Protein-Protein Interactions (PPIs) and is specifically concerned with studies of druggability of PPIs to small molecule modulators. Of particular interest are protein surfaces and interfaces recognizing protein Post-Translational Modifications (PTMs) within multi-domain and multi-subunit protein complexes. We employ a question-driven, multi-disciplinary approach that combines chemical, biophysical and structural techniques with the concepts and approaches of fragment-based and structure-based drug design. The 'chemical probes' we design and develop are evaluated biophysically, structurally and whenever possible within living cells as tools to address biological questions, and as starting leads with potential to be developed as novel therapeutics.

Current and future research efforts are directed towards targeting PPIs and PTM recognition within two protein families of biological and medical relevance:

Ubiquitin System: the Cullin RING E3 ubiquitin ligases (CRLs) multisubunit complexes

Chromatin System: Multidomain proteins of containing paired domains of the epigenetic reader families

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BS42011:  A 4th year module entitled "Advanced Organic Chemistry and Chemical Biology"

PhD Projects

Principal supervisor


Research interests

Chemical and Structural Biology of Targeted Protein Degradation


Award Year
Fellow of the Royal Society of Edinburgh 2023
International Science Prizes awarded since 1990 / Prous Institute-Overton and Meyer Award for New Technologies in Drug Discovery 2022
Fellow of Learned Societies and Colleges / Fellow of Royal Society of Chemistry 2016
International Science Prizes awarded since 1990 / MedChemComm Emerging Investigator Lectureship (2016) 2016
International Science Prizes awarded since 1990 / Royal Society of Chemistry Capps Green Zomaya Award 2016
International Science Prizes awarded since 1990 / ICBS Young Chemical Biologist Award 2015
International Science Prizes awarded since 1990 / EFMC Prize for Young Medicinal Chemist in Academia 2015
International Science Prizes awarded since 1990 / Talented Young Italians Award 2014
Major Personal Funding Awards / ERC Starting Grant 2012
Personal Fellowships / BBSRC David Phillips Fellowship 2010