Research in the Ciulli Lab broadly spans the fields of Chemical Biology and Structural Biology of Protein-Protein Interactions (PPIs) and is specifically concerned with studies of druggability of PPIs to small molecule modulators. Of particular interest are protein surfaces and interfaces recognizing protein Post-Translational Modifications (PTMs) within multi-domain and multi-subunit protein complexes. We employ a question-driven, multi-disciplinary approach that combines chemical, biophysical and structural techniques with the concepts and approaches of fragment-based and structure-based drug design. The 'chemical probes' we design and develop are evaluated biophysically, structurally and whenever possible within living cells as tools to address biological questions, and as starting leads with potential to be developed as novel therapeutics.
Current and future research efforts are directed towards targeting PPIs and PTM recognition within two protein families of biological and medical relevance:
Ubiquitin System: the Cullin RING E3 ubiquitin ligases (CRLs) multisubunit complexes
Chromatin System: Multidomain proteins of containing paired domains of the epigenetic reader families
BS42011: A 4th year module entitled "Advanced Organic Chemistry and Chemical Biology"
University of Dundee spinout Amphista Therapeutics has been designated as one of the world’s most promising biotechnology companies.
Researchers from the University of Dundee have discovered a small molecule that helps to eliminate a Parkinson’s disease-causing protein
From their inception, universities have always been centres of creativity, a gathering point for curious minds. They have also been drivers of our economy, turning ideas into application and creating new businesses.
Chemical and Structural Biology of Targeted Protein Degradation
|Fellows of Learned Societies and Colleges / Fellow of Royal Society of Chemistry||2016|
|International Science Prizes awarded since 1990 / MedChemComm Emerging Investigator Lectureship (2016)||2016|
|International Science Prizes awarded since 1990 / Royal Society of Chemistry Capps Green Zomaya Award||2016|
|International Science Prizes awarded since 1990 / EFMC Prize for Young Medicinal Chemist in Academia||2015|
|International Science Prizes awarded since 1990 / ICBS Young Chemical Biologist Award||2015|
|International Science Prizes awarded since 1990 / Talented Young Italians Award||2014|
|Major Personal Funding Awards / ERC Starting Grant||2012|
|Personal Fellowships / BBSRC David Phillips Fellowship||2010|