Professor Alessio Ciulli

FRSC

Professor

Biological Chemistry and Drug Discovery, School of Life Sciences

Director of the Centre for Targeted Protein Degradation

Centre for Targeted Protein Degradation, School of Life Sciences

Portrait photo of Alessio Ciulli
On this page

Contact

Email

a.ciulli@dundee.ac.uk

Phone

+44 (0)1382 386230

Locations

Discovery Centre

Websites

Ciulli Lab

Research

Research in the Ciulli Lab broadly spans the fields of Chemical Biology and Structural Biology of Protein-Protein Interactions (PPIs) and is specifically concerned with studies of druggability of PPIs to small molecule modulators. Of particular interest are protein surfaces and interfaces recognizing protein Post-Translational Modifications (PTMs) within multi-domain and multi-subunit protein complexes. We employ a question-driven, multi-disciplinary approach that combines chemical, biophysical and structural techniques with the concepts and approaches of fragment-based and structure-based drug design. The 'chemical probes' we design and develop are evaluated biophysically, structurally and whenever possible within living cells as tools to address biological questions, and as starting leads with potential to be developed as novel therapeutics.

Current and future research efforts are directed towards targeting PPIs and PTM recognition within two protein families of biological and medical relevance:

Ubiquitin System: the Cullin RING E3 ubiquitin ligases (CRLs) multisubunit complexes

Chromatin System: Multidomain proteins of containing paired domains of the epigenetic reader families

View full research profile and publications

Teaching

BS42011:  A 4th year module entitled "Advanced Organic Chemistry and Chemical Biology"

PhD Projects

Principal supervisor

Stories

Alessio Ciulli holding a 3D model
View Spinning out

Feature

From their inception, universities have always been centres of creativity, a gathering point for curious minds. They have also been drivers of our economy, turning ideas into application and creating new businesses.

Published on 5 August 2022

Research interests

Chemical and Structural Biology of Targeted Protein Degradation

Awards

Award Year
Fellows of Learned Societies and Colleges / Fellow of Royal Society of Chemistry 2016
International Science Prizes awarded since 1990 / MedChemComm Emerging Investigator Lectureship (2016) 2016
International Science Prizes awarded since 1990 / Royal Society of Chemistry Capps Green Zomaya Award 2016
International Science Prizes awarded since 1990 / ICBS Young Chemical Biologist Award 2015
International Science Prizes awarded since 1990 / EFMC Prize for Young Medicinal Chemist in Academia 2015
International Science Prizes awarded since 1990 / Talented Young Italians Award 2014
Major Personal Funding Awards / ERC Starting Grant 2012
Personal Fellowships / BBSRC David Phillips Fellowship 2010