Dr Peter Taylor
Research Associate in Molecular Physiology
Cell Signalling and Immunology, School of Life Sciences
My research (recently funded by The Wellcome Trust, BBSRC and Scottish Government (RESAS)) centres on the mechanisms of amino acid transport across mammalian cell membranes and their physiological functions in health and disease (including malnutrition). My principal focus is the role of the LAT1 (SLC7A5) amino acid transporter in sensing and signalling "availability" of amino acids to intracellular mechanisms (notably the mTORC1 pathway) which regulate protein synthesis, cell size and growth. We have developed a conditional knockout of LAT1 (SLC7A5) in mice to enable these studies. LAT1 also facilitates the actions of thyroid hormones (which are amino acid derivatives) by transporting them into target cells.
Mechanisms of amino acid transport across mammalian cell membranes