Dr Adrian Saurin
Cellular Medicine, School of Medicine
+44 (0)1382 383963
Adrian graduated with first class honours from the University of Leeds in 1997 before moving to London to study for a PhD at Kings College in Professor Michael Marber’s laboratory at the Department of Cardiology. Following his PhD, Adrian moved to the Protein Phosphorylation laboratory at CRUK’s London Research Institute (headed by Professor Peter Parker), where he first became fascinated by the process of cell division. He subsequently moved to UMC Utrecht, in The Netherlands, to study the role of protein kinases during mitosis in the lab of Professor Geert Kops. Adrian relocated back to the UK in March 2013 to set up his own lab in Dundee studying the spatial regulation of mitotic signalling networks.
In the lab we address fundamental questions about chromosome segregation in an effort to understand why this process goes wrong so frequently in tumour cells. We also focus on some basic cell signalling concepts that have widespread implications outside of cell division. In particular, we aim to uncover how kinases and phosphatases work together to control signal responses. This is important because this "signal integration" allows binary switch like responses to control complex biological outputs.
We use a range of approaches to tackle these problems, including quantitative cell biology, synthetic biology, biochemistry and computation modelling. However, much of our day to day work involves single cell assays and microscopy: Seeing is believing.
For further information including an up-to-date list of project please visit: www.SaurinLab.com
I currently teach on the Cancer Biology modules for 3rd and 4th year undergraduate students. I also teach on the MRes and MSci postgraduate courses.
University of Dundee researchers have discovered that a new type of anti-cancer drug that stops tumour cells from dividing can have long-lasting effects by causing “catastrophic” DNA damage to cells.
Researchers from the University of Dundee have discovered how a cellular ‘traffic light controller’ helps protect against the DNA damage that can lead to cancer.
Researchers at the University of Dundee have discovered a new function within cell division that could allow us to better understand cancer