Postdoctoral Scientist - UOD2329

Postdoctoral Scientist: Ubiquitin-like signalling in the immune system

MRC PPU / Faculty of Life Sciences

Grade 7 (£37,694 - £44,746)

Description:

We are recruiting a highly motivated individual to join us as a Postdoctoral Scientist in Dr Kirby Swatek's laboratory to study the roles of ISG15 modifications, an underexplored and abundant signal of the innate immune response. This position is a fixed-term appointment until 31st March 2029.

The goal of the Swatek lab is to understand the immunomodulatory roles of a ubiquitin-like modifier called Interferon-Stimulated Gene 15 (ISG15). As its name suggests, ISG15 is highly upregulated in interferon-treated and virus-infected cells and marks thousands of proteins to regulate the host immune response. Surprisingly, however, our mechanistic understanding of ISG15's contributions to antiviral signalling is largely unknown. The goal of the position is to characterise the cellular machinery that writes and reads these modifications. The project merges several disciplines, complements ongoing lab efforts, and expands upon our recent discoveries in this area. The postdoc will have access to several exciting new tools in the lab, as well as state-of-the-art equipment conveniently located in the Faculty of Life Sciences. While the successful applicant will work independently, there will be plenty of opportunities to collaborate with researchers within and outside the MRC Protein Phosphorylation and Ubiquitylation Unit.

Please contact Dr Kirby Swatek ([email protected]) for informal enquiries or discussions.

MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU):

The MRC PPU is one of the world's most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk/). Many world-leading researchers in the field of signal transduction have trained within the MRC PPU. The major aims of the MRC PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. A key remit of the MRC PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research.

Your priorities will include:

• Biochemical and Cell biology studies of the ISG15 system
• Performing a wide array of multidisciplinary techniques
• Advising and mentoring undergraduate and PhD student
• Presenting your research at lab meetings, workshops, and conferences
• Writing manuscripts for publication

Who we're looking for:

• Applicants with a PhD (or will complete your PhD studies within six months of the application deadline)
• A track record of academic success
• Experience in tissue culture and proteomic techniques
• A strong background in immune signaling and ubiquitin biology would be advantageous
• Candidates who can teach a small multidisciplinary team of enthusiastic scientists.
• Excellent communication skills.

We are one of the UK's leading universities, internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Our purpose is to transform lives, locally and globally, which we do as a community of staff (Professional Services and academic Schools), students and alumni.