Immune cell signalling action of IL-27 uncovered
Published on 3 August 2022
A collaboration between the labs of Ignacio Moraga and Doryen Bubeck at Imperial have determined how an important component of the immune system
Our immune system relies on complex signalling between different cells to activate different responses. Now, a collaboration between the labs of Ignacio Moraga and Doryen Bubeck at Imperial have determined how an important component of the immune system – a ‘cytokine’ protein called interleukin 27 (IL-27) – elicits an immune response.
IL-27 is made up of two different parts called EBI3 and p28. Together, these make up a signal that is recognized by protein receptors to control inflammation during an immune response. The team used a technique called cryo-electron microscopy to reveal in molecular detail the interaction interfaces between IL-17 and its two receptors that control signalling.
The team say the structure they discovered will provide a blueprint for designing new therapeutic cytokines that can tune the strength of these immune messages.
Read the full paper EMBO Reports: ‘Structural insights into the assembly and activation of the IL-27 signalling complex’.
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