PhD project

Targeting the extracellular matrix remodelling for the treatment of obesity-associated cardio-renal dysfunction

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Application deadline

30 June 2024

Principal Supervisor

Dr Li Kang

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Obesity is a risk factor for many chronic metabolic diseases including heart failure and chronic kidney disease. Our lab demonstrated a tight association between increased deposition of extracellular matrix components (e.g. collagens and hyaluronan), insulin resistance and obesity-associated cardiac and renal dysfunction. However, whether targeting these early extracellular matrix abnormalities and subsequent activation of extracellular matrix receptors is effective in preventing detrimental progression of tissue dysfunction and diseases in obesity is unknown.

This project will use both genetic and pharmacological approaches that reduce extracellular matrix accumulation for cardiac and kidney metabolic and functional phenotyping. Human kidney cells and biopsies and iPSC-derived cardiomyocytes will also be investigated for molecular mechanisms and clinical relevance.

Diversity statement

Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research. We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.

PhD support

See applying for a research degree for more information on the different stages of the PhD application process.

PhD fees

Fees for PhD and other research postgraduate courses

How to apply

  1. Email Dr Li Kang to:
    • send a copy of your CV
    • discuss your potential application and any practicalities (e.g. suitable start date)
  2. After discussion with Dr Kang, formal applications can be made via our direct application system
Learn about applying for a research degree

Supervisors

Principal supervisor

Second supervisor