Learning and Memory in the response to recurrent hypoglycaemia in diabetes

Recurrent hypoglycaemia has both acute and chronic consequences and is greatly feared by people with type 1 diabetes. Work from our laboratory over the last few years has revealed that the brain adaptation to recurrent hypoglycaemia in type 1 diabetes represents a specialised form of memory called habituation. Paradoxically this adaptation reduces symptom awareness of hypoglycaemia increasing the risk of severe hypoglycaemia with loss of consciousness.

In this PhD the candidate will test whether this altered response to hypoglycaemia develops through the mechanism of habituation. the project will involve state of the art in vivo techniques including hyperinsulinaemic hypoglycaemic clamp studies and brain microinjection.

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