Examining the dysfunction of DNA damage repair in synucleinopathies

DNA damage is an emerging stressor implicated in the pathogenesis of neurodegenerative diseases. Our recent research within post-mortem dementia with Lewy body brain tissue has highlighted the dysregulation of several DNA damage repair pathways, alongside the occurrence of a novel nuclear alpha-synuclein pathology. This project would build upon these findings, determining similarities in nuclear pathology and DNA repair dysfunction in other synucleinopathies such as Parkinson’s disease and multiple systems atrophy. Employing a combination of immunohistochemical, biochemical and sequencing based approaches, the work would further delineate the underlying relationship between alpha-synuclein pathology, alterations in DNA damage repair and it’s impact on genomic integrity.

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Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research. We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.