"Replicating your genome: a tale of two helicases "
No
Research
Hosts: Prof Karim Labib & Prof John Rouse
Venue: MSI Small Lecture Theatre, SLS
The Deegan lab investigates fundamental aspects of DNA replication using a range of biochemical, genetic and structural biology approaches, including reconstituting DNA replication in the test tube using purified proteins.
Tom did his PhD at CRUK Clare Hall Laboratories (now The Francis Crick Institute) in London, working on mechanisms of DNA replication initiation with John Diffley. He then moved to Dundee to do a postdoc with Karim Labib, where he established new biochemical and structural biology approaches to interrogate the poorly understood termination phase of DNA replication. During his postdoc, Tom’s work identified a new pathway for DNA replication termination in eukaryotes (Deegan et al., Mol Cell, 2019), and uncovered the mechanisms and regulation of replisome disassembly (Jenkyn-Bedford et al., Nature, 2021). Tom established his independent laboratory at the MRC Human Genetics Unit in Edinburgh in 2021.
In his talk, Tom will discuss unpublished data from a number of ongoing projects in the lab, including investigation of the molecular mechanisms by which accessory DNA helicases drive replication fork progression when the CMG replicative helicase stalls, and the identification of a new pathway for assembling the MCM2-7 catalytic core of CMG in human cells.
No
Yes
DGI Seminar - Dr Tom Deegan, MRC Human Genetics Unit, University of Edinburgh
Staff
United Kingdom
“Metabolic regulation of T cell signalling and function during ageing”
No
Research
Host: Dr Henry McSorley, Dr Andy Howden & Dr Linda Sinclair
Venue: Sir Kenneth & Lady Noreen Murray Seminar Room, CTIR 284
This Seminar is fully funded by external sources
Abstract
Joy Edwards-Hicks’ group investigates how age-related metabolic changes impact lymphocyte signalling and function. An emerging body of data suggests that organismal lipid metabolism plays an important role in the ageing process. In humans, lipids in the blood are used as biomarkers of age-associated diseases, and lipid-centric dietary, pharmacological, genetic, and surgical interventions extend lifespan in model organisms. The human immune system functionally declines with age, but how the organismal lipid environment impacts cellular lipid homeostasis and T cell function is not well understood. The goal of their research is to promote healthy human ageing through reduced age-associated inflammation and improved aged lymphocyte function.
No
Yes
CSI/TIG Seminar by Dr Joy Edwards-Hicks, University of Edinburgh
Staff
United Kingdom