Cell Signalling module (BS32037)
A detailed study of cell-to-cell communication and signal transduction pathways. You will examine how cells regulate key cellular processes and how signalling defects lead to disease
You will develop your understanding of the molecular mechanisms that allow cells to sense, interpret and respond to signals.
You will study how cells communicate through specific receptors and pathways, how molecular switches regulate core processes, the importance of post-translational modifications and what happens when these systems break down.
The module combines lectures with workshops and includes analysis of primary scientific literature, building your skills in data interpretation and critical appraisal alongside the core scientific content.
What you will learn
In this module, you will:
- Examine the mechanisms of cell-to-cell and intracellular communication pathways
- Explore how molecular switches and post-translational modifications regulate core cellular processes
- Investigate how defects in cell signalling contribute to disease
By the end of this module, you will be able to:
- Describe and explain specific cell communication and signal transduction mechanisms
- Analyse and interpret scientific data with accuracy
- Communicate work effectively in written or oral formats
Assignments / assessments
- End of module examination (60%)
- Paper comprehension test (40%)
Teaching methods / timetable
- Lectures
- Workshops
| Week | Content |
| 14 |
Introduction to Cell Signalling Protein Phosphorylation |
| 15 | Protein ubiquitylation |
| 16 |
Other key post-translational modifications Mass spectrometry methods for studying cell signalling |
| 17 | Signalling adapters and secreted messengers |
| 18 | Molecular switches and nuclear receptors |
| 19 | Receptor and non-receptor tyrosine kinases |
| 20 | TLR signalling |
| 21 |
G protein coupled receptors PI3K and AKT signalling Paper comprehension test |
| 22 | AMPK and mTOR signalling |
| 23 | NKKB signalling and signalling crosstalk |
| 24 | Exam preparation session |
Courses
This module is available on the following courses: