Protein Degradation in Focus Symposium

Welcome 
Large Lecture Theatre, Medical Sciences Institute, School of Life Sciences 

Iain Gillespie, Principal of the University of Dundee

Therapeutic Development I 
Large Lecture Theatre, Medical Sciences Institute, School of Life Sciences

Session Chair: Alessio Ciulli

Speakers

• Craig Crews (Keynote), Tik-TAC-Toe: A Heterobifunctional for Every Need
• Mikihito Naito, Protein degradation induced by IAP-based PROTACs (SNIPERs)
• Ben Ebert, Targeted protein degradation for the modulation of transcription
• Shaomeng Wang, Targeting undruggable proteins through degradation

Discovery Chemistry & Design I 
Large Lecture Theatre, Medical Sciences Institute, School of Life Sciences

Session Chair: Dafydd Owen

Speakers

• Dan Nomura, Reimagining Druggability using Chemoproteomic Platforms
• Fleur Ferguson, Interrogating the Druggable Proteome with Proximity Pharmacology
• William Farnaby, Pursuing targeted protein degradation for investigating CNS disease
• Laura Serini, Short Talk: A predictive screening platform for targeted degradation of cell surface proteins using SureTACs
• Matthias Hinterndorfer, Short Talk: Targeted protein degradation via intramolecular bivalent glues
• Katherine McPhie, Short Talk: Chemical Biology Approaches to Explore the Ligandability of TRIM E3 Ligases

Molecular Mechanisms & Biology I 
Large Lecture Theatre, Medical Sciences Institute, School of Life Sciences

Session Chair: Ian Churcher

Speakers

• Yifat Merbl, Proteasome Profiling: global views of protein degradation
• Ronald Hay, Targeted degradation of the Promyelocytic Leukaemia protein by arsenic
• Keriann Backus, Chemoproteogenomic approaches to stratify the functional and therapeutically relevant proteome
• Martin Volker Schmiedel, Short Talk: Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drugresistant mycobacteria
• Ella Livnah, Short Talk: Rationally designed bifunctional ligands induce intracellular precipitation of homomeric protein targets
• Alejandro Rojas-Fernandez, Short Talk: Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

Molecular Mechanisms & Biology II,
Large Lecture Theatre, Medical Sciences Institute, School of Life Sciences

Session Chair: Craig Crews

Speakers

• Brenda Schulman (Keynote), Signaling through the ubiquitin-proteasome system
• Eric Fischer, Combining protein design and directed evolution for degrader discovery
• Bekky Feltham, Unlocking the Potential of Tag-targeting PROTACs: In Vivo Discoveries and Novel Perspectives on
  Substrate Ubiquitination

Discovery Chemistry & Design II, 
Large Lecture Theatre, Medical Sciences Institute, School of Life Sciences

Session Chair: Kirsten McAulay

Speakers

• Ivan Đikić, Identification of novel molecular glue degraders
• Christina Woo, Chemical biology studies of the thalidomide-binding domain of cereblon
• Michael Erb, Systematic remodeling of protein-ligand surfaces for the prospective discovery of molecular glues
• Johanna Huchting, Short Talk: Integrated screening and knowledge platform for molecular degrader discovery
• Mikołaj Słabicki, Short Talk: Expanding the human zinc finger degrome targeted by glutarimide analogs through
  CRBN

Molecular Mechanisms & Biology III, 
Large Lecture Theatre, Medical Sciences Institute, School of Life Sciences

Session Chair: Hannah Maple

Speakers

• Georg Winter, Identification and characterization of small-molecule degraders
• Nicolas Thomä, The wonderful (and mysterious) world of molecular glues
• Gopal Sapkota, Targeted dephosphorylation of phospho-proteins through induced-proximity
• Charlotte Crowe, Short Talk: Mechanism of degrader-targeted protein ubiquitinability
• Jiho Park, Short Talk: Polymerization of ZBTB transcription factors regulates chromatin occupancy
• David Nie, Short Talk: Recruitment of FBXO22 for Targeted Degradation of NSD2

Discovery Chemistry & Design III, 
Large Lecture Theatre, Medical Sciences Institute, School of Life Sciences

Session Chair: Brenda Schulman

Speakers

• Alessio Ciulli (Keynote), We keep degrading! CeTPD’s past, present and future
• Cristina Mayor Ruiz, Degraders: unlocking drug discoveries and navigating resistance challenges
• Stefan Knapp, Development and validation of PROTACs and E3 ligase ligands as selective chemical tools

Therapeutic Development II,
Large Lecture Theatre, Medical Sciences Institute, School of Life Sciences

Session Chair: Valentina Spiteri

Speakers

• Danette Daniels, Targeting chromatin regulatory proteins and disease with therapeutic degraders
• Ingrid Wertz, Co-opting the Ubiquitin System for Therapeutic Benefit
• Angela Cacace, Advancements in PROTAC technology:  breaking down barriers in Neuroscience targeted drug development
• Andrea Testa, Short Talk: Degradation of Brd9 by a novel “targeted glue”
• Vesna Vetma, Short Talk: Targeting cancer with small molecule pan-KRAS degraders
• Rebecca Stevens, Short Talk: Direct-to-Biology for High-Throughput PROTAC Synthesis and Biological Evaluation