Stem Cell Biology module (BS42031)

In this module you will build on your existing knowledge to the explore the frontiers of stem cell biology.

You will study fundamental principles of stem cells. You will investigate the mechanisms that maintain or direct their differentiation into different cell lineages. You will also look at the molecular control of cell identity and potency.

The module covers embryonic and adult stem cells in both normal and disease contexts. This includes topics like:

• epigenetic regulation
• reprogramming and iPS cells
• asymmetric cell division
• tissue stem cells

What you will learn

In this module, you will:

• identify and describe different types of stem cells and their origins and functions
• explain the molecular mechanisms controlling cell identity, fate and potency. You will learn to compare these with reprogramming mechanisms
• critically review scientific literature in stem cell biology and distil relevant information

By the end of this module, you will be able to:

• identify different types of stem cells and describe their origins and functions
• explain mechanisms underlying the control of cell identity and compare them to reprogramming
• propose experiments to test hypotheses in stem cell biology and interpret potential outcomes

Assignments / assessment

Literature analysis under exam-like conditions

The paper will be given to you at the start of the module

• Formative assessment (not graded) will be given around week 6
• You will take the assessment around week 8

2-hour final exam (60%)

• This will consist of written long-answer questions
• You will have a choice of two from three questions
• This will take place in the University's April to May exam diet

Teaching methods / timetable

• Lectures
• Approximately 2 hours per week during semester
• Workshops
• In preparation for the coursework assessment
• To provide feedback on coursework
• Approximately 4-6 hours in total