Facility

Biomarker and Drug Analysis Laboratory (BMDA)

Harnessing the power of biomarker and drug analysis for clinical research and drug development

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Biomarker and Drug Analysis Laboratory (BMDA)
Address

Jacqui Wood Centre

James Arrott Drive

School of Medicine

Ninewells Hospital & Medical School

University of Dundee

Dundee DD2 1UB

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Campus

Ninewells Campus

Group or department

School of Medicine

Established in 2011, the Biomarker and Drug Analysis Laboratory (BMDA) provides analytical services for quantitative and qualitative analyses of soluble biomarkers, drug compounds and metabolites with state-of-the-art LC-MS/MS instruments to the researchers at the University of Dundee and to external academics and industrial clients. The laboratory is Good Clinical Laboratory compliant since 2016.

Capabilities 

Pharmacokinetic analysis

  • Quantification of drug compound and metabolites
  • Structural elucidation of drug metabolite 

Biomarker quantification

  • Biomarker discovery- proteomics and metabolomics
  • Biomarker validation 

Mechanistic elucidation

  • Label-free proteomics
  • In vivo SILAC (Stable Isotope Labelling with Amino Acids in Cell Culture) analysis\
Speciality

BMDA has built a portfolio of 3 analytical platforms and assays in the last few years for a wide range of clinical and preclinical appliactions.

Biomarker platform/assay Analytical validation Preclinicial validation Clinical application
 Desmosine

 Neurosteroids

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 Pathway enhanced in vivo SILAC

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Technology and facilities

Mass spectrometry

  • Thermo LTQ-Orbitrap
  • Thermo Quantum Ultra
  • Waters Quattro Premier
  • Waters Micro QQQ

Liquid chromatography

  • Agilent 1200 nano-LC
  • Agilent 1100 LC
  • Thermo Ultimate 3000 LC
  • Waters Acquity UPLC
  • Waters Micro LCs
People

Mrs Elena Kuzmanova
Research Technician

Mr Alun Barton
Senior Research Technician

Dr. Jeffrey Huang
Head of Biomarker and Drug Analysis Core Facility
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Enquiries

Dr Jeffrey Huang

+44 (0)1382 386901

j.t.j.huang@dundee.ac.uk

Facility type

Research facility