Facility
Biomarker and Drug Analysis Laboratory (BMDA)
Harnessing the power of biomarker and drug analysis for clinical research and drug development
Jacqui Wood Centre James Arrott Drive School of Medicine Ninewells Hospital & Medical School University of Dundee Dundee DD2 1UB
Ninewells Campus
Established in 2011, the Biomarker and Drug Analysis Laboratory (BMDA) provides analytical services for quantitative and qualitative analyses of soluble biomarkers, drug compounds and metabolites with state-of-the-art LC-MS/MS instruments to the researchers at the University of Dundee and to external academics and industrial clients. The laboratory is Good Clinical Laboratory compliant since 2016.
Capabilities
Pharmacokinetic analysis
- Quantification of drug compound and metabolites
- Structural elucidation of drug metabolite
Biomarker quantification
- Biomarker discovery- proteomics and metabolomics
- Biomarker validation
Mechanistic elucidation
- Label-free proteomics
- In vivo SILAC (Stable Isotope Labelling with Amino Acids in Cell Culture) analysis\
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BMDA has built a portfolio of 3 analytical platforms and assays in the last few years for a wide range of clinical and preclinical appliactions. |
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| Biomarker platform/assay | Analytical validation | Preclinicial validation | Clinical application |
| Desmosine |
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| Neurosteroids |
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| Pathway enhanced in vivo SILAC |
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Technology and facilities
Mass spectrometry
- Thermo LTQ-Orbitrap
- Thermo Quantum Ultra
- Waters Quattro Premier
- Waters Micro QQQ
Liquid chromatography
- Agilent 1200 nano-LC
- Agilent 1100 LC
- Thermo Ultimate 3000 LC
- Waters Acquity UPLC
- Waters Micro LCs
Mrs Elena Kuzmanova
Research Technician
Mr Alun Barton
Senior Research Technician
Dr. Jeffrey Huang
Head of Biomarker and Drug Analysis Core Facility
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