Predicting Binding Sites: Moving Beyond the Static View

Host : Professor Geoff Barton

Venue: MSI Small Lecture Theatre, SLS

Abstract: 

In this talk, David will first introduce P2Rank, a protein binding site prediction method developed within our group. He will then discuss how the development and evaluation of this tool led us to explore the conformational flexibility of binding pockets in known experimental structures. Finally, David will show how this exploration paved the way for the development of new benchmarks and methods to identify more dynamic types of binding sites, such as cryptic binding sites.