Event
“Non-canonical ubiquitination by HOIL-1 and other RBR E3 ubiquitin ligases”
Wednesday 8 May 2024
Non-canonical ubiquitylation mini-series by Dr Bernhard Lechtenberg Walter and Eliza Hall Institute of Medical Research (WEHI), Melbourne, Australia
***Online Only Seminar (via TEAMS)***
“Non-canonical ubiquitination by HOIL-1 and other RBR E3 ubiquitin ligases”
The speaker: Bernhard Lechtenberg is a laboratory head in the Ubiquitin Signalling Division at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, Australia. A German native, Bernhard obtained his PhD from the University of Cambridge, UK, before undertaking postdoctoral training at the Sanford Burnham Prebys Medical Discovery Institute (SBP) in San Diego, USA. During his postdoc, Bernhard became first interested in the ubiquitin system and started working on understanding the structure, regulation and catalytic mechanism of the RING-between-RING (RBR) E3 ubiquitin ligase HOIP. In 2019, Bernhard relocated to WEHI to establish his own research group to continue and expand on this work. His laboratory now focuses on understanding the catalytic mechanisms, structures, regulation, and biological functions of (RBR) E3 ubiquitin ligases, with a particular emphasis on their role in inflammation and neurodegenerative diseases. In addition to this, Bernhard is a program lead in the recently established Australian Centre for Targeted Therapeutics (ACTT) with the mission to develop novel protein degrader drugs.
Teaser: In his presentation, Bernhard will first outline his lab’s recent work on the structure and function of the RBR E3 ubiquitin ligase HOIL-1 and how it helped to define the unifying principles of RBR regulation and catalysis. In the second part, he will present unpublished work on the substrate specificity of HOIL-1 and its ability to ubiquitinate non-canonical substrates such as serine and threonine residues and non-proteinaceous substrates such as sugars.
Meeting ID: 326 741 698 196
Passcode: Eq28jy