Regulation and mechanics in polarity

About the project

Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. We aim to understand the role of protein complexes including the exocyst. This project seeks to answer mechanistic questions regarding

1. the regulation of protein structural mechanics in polarized trafficking
2. the consequences of signalling on this pathway and its organization

Because signalling in polarized trafficking is affected in metastasis of cancer, we position our research for the broadest impact in forming a foundation for drug discovery. We take a reconstitution and synthetic biology approach in combination with the powerful tools available for microscopy. Our philosophy is to address these questions of challenging biology using quantitative methods in a hypothesis-driven approach.

You will join a cohort of students in a comprehensive induction programme, later participating in a wide range of other training activities, including student-led symposia and retreats. You will also have the opportunity to attend annual symposium and meetings as their research and training progresses.

Diversity statement

Our research community thrives on the diversity of students and staff which helps to make the University of Dundee a UK university of choice for postgraduate research. We welcome applications from all talented individuals and are committed to widening access to those who have the ability and potential to benefit from higher education.