PhD project

Regulation and mechanics in polarity

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Application deadline

31 October 2023

About the project

Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. We aim to understand the role of protein complexes including the exocyst. This project seeks to answer mechanistic questions regarding

  1. the regulation of protein structural mechanics in polarized trafficking
  2. the consequences of signalling on this pathway and its organization

Because signalling in polarized trafficking is affected in metastasis of cancer, we position our research for the broadest impact in forming a foundation for drug discovery. We take a reconstitution and synthetic biology approach in combination with the powerful tools available for microscopy. Our philosophy is to address these questions of challenging biology using quantitative methods in a hypothesis-driven approach.

You will join a cohort of students in a comprehensive induction programme, later participating in a wide range of other training activities, including student-led symposia and retreats. You will also have the opportunity to attend annual symposium and meetings as their research and training progresses.

How to apply

  1. Email Dr David Murray ( to:
    • send a copy of your CV
    • discuss your potential application and any practicalities (e.g. suitable start date)
  2. After discussion with Dr Murray, you can apply via our direct application system.
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