2 Apr 2018

Structure of Intellectual Disability protein solved

Scientists at the University of Dundee have identified the effects of a mutation that gives rise to a form of Intellectual Disability. Intellectual Disability is a type of developmental brain disorder in young patients which to date remains poorly understood and is incurable. Researchers in the School of Life Sciences at Dundee focussed on mutations in the OGT gene, which plays a critical role in protecting brain cells against stress. In patients harbouring OGT mutations, this protective effect is lost. In the new research, published in the journal Cell Chemical Biology, the team of Dundee scientists ...

Structure of Intellectual Disability protein solved

27 Mar 2018

Identifying drug candidates for neglected diseases

The University of Dundee’s Drug Discovery Unit (DDU) will collaborate with the not-for-profit research and development organisation Drugs for Neglected Diseases initiative (DNDi) and GlaxoSmithKline (GSK) in a bid to discover new pre-clinical drug candidates targeting two parasitic neglected tropical diseases (NTDs), leishmaniasis and Chagas disease. “This agreement will be a boost to our long-term strategy to develop entirely new chemical entities to treat neglected diseases and provide better treatment options for patients. Today, treatments for both leishmaniasis and Chagas disease...

Identifying drug candidates for neglected diseases

22 Mar 2018

Signalling study sheds light on conditions from alopecia to cancer

Researchers from the University of Dundee and the Francis Crick Institute have made a significant discovery about a cellular pathway associated with developmental defects and a myriad of diseases ranging from alopecia to colorectal cancer. The research, jointly led by Dundee’s Dr Gopal Sapkota and Professor Sir Jim Smith of the Crick, examined the role of a protein called PAWS1 in the Wnt signalling pathway, which is of fundamental importance in shaping developing embryos and controlling cell fate in adults. Mutations that cause slight alterations in Wnt signalling can lead to the developmental defec...

Signalling study sheds light on conditions from alopecia to cancer

19 Mar 2018

Digital break-up souvenirs sought for Museum of Broken Relationships

The museum of Broken Relationship in Croatia is home to physical souvenirs from romantic break up, gathered from across the world For the first time digital souvenirs are now being collected in partnership with University of Dundee’s interdisciplinary Living Digital group The momentos sought might include unanswered texts, ominous email subject lines, Facebook messages, terrible Tinder profiles, Snapchat screengrabs or emotional photographs Not so long ago, the souvenirs of a romantic relationship involved mixtapes, letters, jewellery, photographs and items of clothing. After a breakup, perhaps the...

Digital break-up souvenirs sought for Museum of Broken Relationships

15 Mar 2018

Argument technology helping to combat fake news

Cutting-edge argument technology developed at the University of Dundee will be used by thousands of school pupils across the UK this month as part of a major BBC initiative supporting young people to identify real news and filter out fake or false information. The Centre for Argument Technology (ARG-tech) at the University of Dundee is a world leader in developing technology which can dissect and analyse argument and debate. Among other projects, ARG-tech researchers have collaborated over the past decade with the BBC Religion & Ethics team who produce Radio 4’s `Moral Maze’ programme. Now ...

Argument technology helping to combat fake news