View the list of publications written by Prof Tom MacDonald and Dr Isla MacKenzie.

MacDonald T, Mackenzie S, Wei L. Novel ways to get good trial data: the UK experience. In: Weisfeld N, English RA, and Claiborne AB, Rapporteurs; Forum on Drug Discovery, Development, and Translation; Board on Health Sciences Policy; Institute of Medicine: Envisioning a Transformed Clinical Trials Enterprise in the United States: Establishing an Agenda for 2020: Workshop Summary. National Academic Press, Washington DC, Appendix J pages 181-190. Available at: (accessed 20th April 2012)









Rutherford D, Wei L, Mackenzie IS, MacDonald TM. The Philosophy of Doing Observational Medicines Safety Research. Journal of Clinical Research and Bioethics. 2012 (In Press).


Nadir MA, Rekhraj S, Wei L, Lim TK, Davidson J, MacDonald TM, Lang CC, Dow E and Struthers AD. Improving The Primary Prevention Of Cardiovascular Events By Using Biomarkers To Identify Individuals With Silent Heart Disease. Journal of the American College of Cardiology 2012 (In Press)



Wei L, Professor MacDonald T, Shimi S. The association between appendicectomy in females and subsequent pregnancy rate: A cohort study. Fertility and Sterility 2012 (In Press)


Brown MJ, McInnes GT, MacDonald TM. Initial combination therapy for treatment of hypertension. Lancet 2011;377:1492.






Wei L., MacDonald TM, Shimi SS. Appendicectomy is associated with increased pregnancy rate: A cohort study. Annals of Surgery 2011 (In Press)





Chen R, Hu Z, Wei L, Ma Y, Liu ZM, Copeland JR. Incident dementia in a defined elderly Chinese population PLoS One 2011;6(9):e24817. Epub 2011 Sep 23.






Flynn RW, Doney A. Antithrombotic medicines following intracerebral haemorrhage: where's the evidence? Therapeutic Advances in Drug Safety 2011;2: 205-211




Flynn RW. Survival analysis. Journal of Clinical Nursing 2011 (in-press)








Flynn RW, Macdonald TM, Murray GD, Doney AS. Antiplatelet Medicine Prescribing and Subsequent Events Following Intra-cerebral Haemorrhage. Stroke 2010;41:2606-11.






Macdonald T, Hawkey C, Ford I. Academic sponsorship. Time to treat as independent. BMJ. 2010 Nov 30;341:c6837. doi: 10.1136/bmj.c6837.





Schembri S, Morant S, Winter John, MacDonald TM. Influenza but not pneumococcal vaccination protects against all cause mortality in patients with chronic obstructive pulmonary disease. Thorax 2009;64:567-72.










MacDonald T. Tom MacDonald replies to Marisa de Andrade. BMJ. 2009 Oct 21;339:b4281. doi: 10.1136/bmj.b4281.








Irvine F, Almond A, Robertson S, Donaldson K, Flynn RW, Isles C. Getting the right medicine: a survey of haemodialysis patients in SW Scotland. Pharm J 2009;283:575-576.




Chessell G, Duguid KP, Jamieson MJ, MacDonald TM, McHardy KC, Towler HMA. & Petrie JC. Essential Clinical Signs. Churchill Livingstone, 1990.


MacDonald TM, McDevitt DG Antianginal and Beta-adrenoceptor Blocking Drugs. In: Meyler's Side Effects of Drugs. 12th Edition (Ed N.M.G Dukes) Elsevier Science, Oxford, 1992, chapter 19, 431-469.


MacDonald TM, McDevitt DG. The Tayside Medicines Monitoring Unit. In: Strom B.L. (Editor) Pharmacoepidemiology (Second edition), John Wiley, Chichester 1994, chapter 18, 245-255.


MacDonald TM. Hypertension. In: Cardiology: Peer Selected Citations '94. Cleland J, Crake T, MacDonald TM, Pennell D, Slade A. (Editors). Current Medical Literature, London, 1994, chapter 6, 129-150.


MacDonald TM. The Tayside Medicines Monitoring Unit In: Walker SR (editor) Databases for Pharmacovigilance. Medical Benefit Risk Foundation / Centre for Medicines Research, Carshalton, 1996, Chapter 3, p 17-25.


MacDonald TM. Hypertension. In: Cardiology: Peer Selected Citations 1996. Cleland J, Crake T, Lefroy D, MacDonald TM, Pennell D, Redington A, Slade A. (Editors). Current Medical Literature, London, 1996, chapter 6, 116-136.


Lim PO, MacDonald TM. Antianginal and Beta-adrenoceptor Blocking Drugs. In: Meyeler's Side Effects of Drugs. 13th Edition (Ed N.M.G Dukes) Elsevier Science, Oxford, 1996, chapter 18, 488-535.


Davey PG, Malek M, Dodd T, MacDonald TM. Pharmacoeconomics and drug prescribing. In: Speight TM, Holford HG (editors) Avery's Drug Treatment (4th Ed) ADIS International, Chester, 1997, Chapter 10, p393-422.


MacDonald TM. Studies of NSAID toxicity from the Tayside Medicines Monitoring Unit. In: Rainsford KD (Editor) Side Effects of Anti-Inflammatory Drugs IV, Kluwer


Evans JMM, MacDonald TM. The Tayside Medicines Monitoring Unit (MEMO). In: Strom B.L. (Editor) Pharmacoepidemiology (Third edition), John Wiley, Chichester 2000, Chapter 22, 361-374.


Lim PO, MacDonald TM. Antianginal and Beta-adrenoceptor Blocking Drugs. In: Meyeler's Side Effects of Drugs. 14th Edition (Ed N.M.G Dukes) Elsevier Science, Oxford, 2000, chapter18, 575-628.


De Vries C, Evans J, MacDonald TM. MEMO record linkage – the shape of things to come. In: McGavock H (Editor) Handbook of drug use research methodology. UK Drug Utilisation Research Group, Newcastle-Upon-Tyne, 2000, Chapter 18, 262- 274.


Steinke D, Evans J, MacDonald TM. MEMO in the UK. In: Mann RD (Ed) Pharmacovigilance, John Wiley, Chichester, 2002 Chapter 28, 1-9.


Patterson D, Brady AJB, MacDonald TM. Compliance to concordance in hypertension. In: Brady AJB, Petrie J (Eds). New perspectives in Hypertension. Merit Publishing International, Weybridge, 2004. Chapter17, 172-182.


Wei L, MacDonald TM. The Tayside Medicines Monitoring Unit (MEMO). In: Strom B.L. (Editor) Pharmacoepidemiology (Fourth edition), John Wiley, Chichester 2005.


Patterson D, Brady AJB, MacDonald TM. Compliance to concordance in hypertension. In: Brady AJB, Petrie J (Eds). New perspectives in Hypertension 3rd Edition. Merit Publishing International, Weybridge, 2005. Chapter17, 174-182.


Parthasarathy HK, MacDonald TM. Primary hyperaldosteronism and other forms of mineralocorticoid hypertension. In : Lip G and Hall R. Comprehensive Hypertension. Chapter 67. Elsevier, New York 2007


Parkinson J, Wei L, MacDonald TM. View from the real world. In:Davies M, Kermani F. (Eds). Patient Compliance: Sweetening the pill. Gower, Aldershot 2006 Chapter 2, 7-21.



















Nolan J, Flapan A.D, Capewell S, MacDonald TM, Neilson JMM, Ewing DJ. Decreased heart rate variability in chronic heart failure and the effect of angiotensin converting enzyme inhibitor therapy. Clinical Autonomic Research 1991; 1: 89-90.







Davey PG, MacDonald TM. Postmarketing Surveillance of Quinolones 1990-1992. Drugs 1993; 45(Suppl. 3): 46-53.










Nathwani D, MacDonald TM, Davey PG. Cost-effectiveness of acyclovir for varicella infections in immunocompetent patients - a British perspective. Infectious Diseases In Clinical Practice 1995; 4: 138-145.


Clarkson PBM, Wheeldon NM, MacLeod C, MacDonald TM. Systolic and Diastolic effects of ï?¢-adrenergic stimulation in normal man. American Journal of Cardiology 1995; 75: 206-209.





Wheeldon NM, MacDonald TM, Prasad N, MacLean D, Peebles L, McDevitt DG. A double-blind comparative study of the anti-hypertensive efficacy and tolerability of bisoprolol and atenolol in patients with essential hypertension. Quarterly Journal of Medicine 1995; 88: 565-570.







Evans JMM, McDevitt DG, MacDonald TM. The Tayside Medicines Monitoring Unit (MEMO): a record-linkage system for pharmacovigilance. Pharmaceutical Medicine 1995; 9: 177-184.


MacDonald TM. Side effects of non-steroidal anti-inflammatory drugs: Studies from the Tayside Medicines Monitoring Unit. Immunopharmacology 1995; 3: 321-326.




Dewar JA, Stewart HJ, MacDonald TM. Tamoxifen compliance in a clinical trial. The Breast 1996; 5: 152-153.





Pritchard G, Webster J, Petrie JC, MacDonald TM. The effects of trandolapril and NSAIDs on the blood pressure of hypertensive subjects requiring analgesia. Journal of Human Hypertension 1996;10:763-767.


MacDonald TM. Treatment of depression. Prescription for success? Primary Care Psychiatry 1997;3(Suppl 1):S7-S10.














Grewar J, Matthews J, McMahon AD, MacDonald TM. Capturing data on over-the-counter medicines in community pharmacies: a methodological study Pharmaceutical Journal. 1997;259:736-9.





Prach AT, MacDonald TM, Hopwood DA, Johnston DA. Increasing incidence of Barrett's oesphagus: education, enthusiasm or epidemiology? Lancet 1997;350:933.




Grewar J, MacDonald TM. Hay fever symptoms and over the counter hay fever remedies: a community pharmacy study. International Journal of Pharmacy Practice 1998;6:22-29.






Shiels P, Lim PO, MacFadyen RJ, MacDonald TM. Heart failure with normal systolic function. Brit J Cardiol 1998;5:533-536.








Lawrenson R. Watts G. Tylee A. MacDonald TM. et al. Pattern of antidepressant prescription in general practice: Lessons from the MediPlus database. Primary Care Psychiatry. 1999;5(Suppl. 1):S3-S7


MacDonald TM. The impact of psychotropic medication on daily activities: psychotropic drugs and road traffic accidents: The MEMO study. Primary Care Psychiatry 1999;5(Suppl. 1):S13-S16.


Hindmarch I. Watts G. MacDonald TM. The impact of psychotropic medication on daily activities: The behavioural toxicity of antidepressants. Primary Care Psychiatry. 1999;5(Suppl. 1): S17-S20.





Lim PO, Rodgers P, Cardale K, Watson A, MacDonald TM. Potentially high prevalence of primary aldosteronism in a general practice population in Tayside, Scotland. Lancet 1999;353:40.









Lim PO, Brennan G, Jung RJ, MacDonald TM. Diagnosing primary aldosteronism with the frusemide stimulation test in hypertensive patients with raised aldosterone to renin ratio. Medical Biochemistry 1999;1:225-231.






Evans JMM, MacDonald TM. Record-linkage: improving patient care? Health Service Computing. 2000;Jan/Feb:14-16.







Lim PO, MacDonald TM. Hyperaldosteronism: The hidden epidemic. Modern Hypertension 2000;2:2-5.

























Parkinson J, MacDonald TM. Pharmacoepidemiology and the use of personalised healthcare data. Regulatory Affairs Bulletin 2001;84:8-11.

















Tzemos N. Patterson D. MacDonald TM. Dundee step test: A novel non-invasive method of assessing endothelial function in man. Scottish Medical Journal 2002;47:3-6













MacDonald TM. Introduction, discussion and concluding remarks. Rheumatology 2003:42(Suppl 3): iii1-2, iii64-67.







Krishnan H, MacDonals TM. Aldosterone: 50 years on from its discovery. Health & Ageing 2004; July/August:ii-iv.




MacDonald TM. Morant SV. Goldstein JL. Bjorkman D. Use of newer NSAIDs in high-risk patients: Is there channeling bias? Evidence-Based Gastroenterology 2004;5:44-45.






MacFadyen† RJ, MacDonald TM Cardiovascular safety of COX-2 inhibition: time to inform systems of postmarketing surveillance? Therapy 2005; 2:3, 1–4.









MacDonald TM. A Europeans Perspective of COX2 Drug Safety. Journal of Cardiovascular Pharmacology 2006;47 Suppl 1:S92-7.



Aird FK, Greene SA, Ogston SA, MacDonald TM, Mukhopadhyay S. Vitamin A and lung function in CG. Journal of Cystic Fibrosis 2006;5:129-131.









MacDonald TM. Non-steroidal anti-inflammatory drugs and renal damage. Prescribers Journal 1994; 34: 77 - 80.


Clarkson P, Wheeldon NW, MacDonald TM. Left ventricular diastolic dysfunction. Quarterly Journal of Medicine 1994; 87: 143-148.


MacDonald TM, Wheeldon NM. The economics and ethics of treating hypertension. Current Opinion In Cardiovascular Medicine 1993; 12: 39-46.






Prasad N, MacFadyen RJ, MacDonald TM. Update on ambulatory blood pressure monitoring. Quarterly Journal of Medicine 1996;89: 95-102.







Leary A, MacDonald TM. Interactions between alcohol and drugs. Proceedings of the Royal College of Physicians of Edinburgh 1999;29:137-143.





Leary A.C., MacDonald T.M. Contraception for the hypertensive patient. Gynaecology Forum 2000;5:29-32

















Prasad N, Cargill R, Lang CC, Wheeldon NM, MacDonald TM. Ecstasy and meningococcal Meningitis. Infectious Diseases in Clinical Practice 1994; 3: 122-3.





McFadyen RJ, MacDonald TM, Clarkson P, Wheeldon NM. Open access echo-cardiography: Single assessment may be dangerous. British Medical Journal 1995; 311: 327.









McGilchrist MM, Morris AD, Davey PG, McDevitt DG, MacDonald TM. Patient-specific PACT data: available now. BMJ;1998:1530-1.










Donnan PT. Steinke DT. Davey PG. MacDonald TM. Selegiline and mortality in subjects with parkinson's disease: A longitudinal community study Neurology. 2001;57:368-370.


MacDonald TM, Wei L. Effect of ibuprofen on cardioprotective effect of aspirin. Lancet 2003;361:1559.


Krishnan PH, MacDonald T. The current epidemic of primary aldosteronism: causes and consequences. Journal of Hypertension 2004;22:863-9.



















Mackenzie IS, Brown MJ. Horizons in Medicine 17. Management of hypertension: lessons from the eponymous syndromes. RCP, London, 2006.













Cuthbertson DJR, Flynn RW, Leese GP, Jung RT. Evaluation of a managed clinical thyroid network. Int J Clin Prac 2006;60:660-664.