Sharon King

+44 (0)1382 383274
Manager Tayside Biorepository

Biography

Sharon graduated in 2004 from the University of St Andrews (Scotland) with a joint BSc honours degree in Biology with French. She then completed her PhD in the Department of Pathology at University of Dundee (Scotland) focusing on the role of KiRas4A in hormone dependent responses in the renal tubule and its association with renal carcinogenesis.

Sharon has worked within a variety of translational based projects using human and mouse tissues, including PLK1 repression in breast cancer where she was awarded the Sir Alistair Currie Prize in St Andrews, Scotland for her work. In addition, Sharon has used stress reporter mice to study in real time a variety of disease models using transgenic oxidative stress biomarkers. More recently Sharon completed a project to better understand the molecular mechanisms of disease in anti-NMDA R encephalitis.

Over the last 11 years, Sharon has maintained strong connections with the Tayside Tissue Bank, (Dundee, Scotland) in order to use invaluable patient samples for a wide range of molecular and cellular techniques. As of July 2015, Sharon made the decision to become more closely involved with governing the use of human tissue as an invaluable research tool and became manager of the Tayside Tissue Bank which is part of a wider Scottish Biorepository Network supported by the Chief Scientist Office.

Research

Lectures and conferences

S King, A Woolston, J Sharkey (2013) “Evaluating stress biomarkers in the cuprizone model of multiple sclerosis.

The Pathological Society. Edinburgh International Conference Centre

S King, D Meek, (2010) St Andrews. P53 dependent repression of Plk1. The Journal of Pathology Suppl 2010. Awarded Sir Alistair Currie prize.

S King, McKenzie, Meek et al (2010) “P53 repression of plk1”. The 15th International p53 Workshop. Philadelphia USA. Awarded £500 Travel Grant from the Pathological Society of Great Britain and Northern Ireland: £500 Travel Grant

Publications

S I King, S Bray, S Galbraith, L Christie & S Fleming (2014) Evidence for aldosterone dependent growth of renal cell carcinoma. International Journal of Experimental Pathology.

S I King, S Bray, PR Quinlan, L Jordan, CA Purdie, AM Thompson, and DW Meek. Histological detection of PLK1 in primary breast cancer is associated with TP53 mutation and denotes poor clinical outcome. (2012) Breast Cancer Res, 14 R40.

Joint first authorship: S I King, McKenzie L, L Marcar, S Nicol, SS Dias, K Schumm, P Robertson, J-C Bourdon, N Perkins, F Fuller-Pace and DW Meek. (2010) p53-dependent repression of polo-like kinase-1 (PLK1). Cell Cycle, 9, 4200-4212. “News and Views” commentary on this article published in Cell Cycle (2010) 9, 4432.