Sara Brown

+44 (0)1382 383210
Wellcome Trust Senior Research Fellow in Clinical Science, Professor of Molecular & Genetic Dermatology

Bio

Teaching

BMSc - Human Genetics and Experimental Medicine - lecturer 2012, 2013

Year 2 undergraduate dermatology teaching for medical students - Genetics; Dermatitis - 2012, 2013

Advanced Paediatric Dermatology Course - co-organsier - 2010, 2011, 2012, 2013

StR Research Course - lecturer - 2012, 2013

The Skin Biology Research Course (TheSIS) - invited speaker & mentor - 2010, 2011, 2012, 2013

DRAMS student-led journal club - 2013

Research

Genetic mechanisms in atopic eczema

Atopic eczema is an itchy inflammatory skin disease. It may cause significant morbidity and accounts for approximately 25% of children referred to a hospital dermatology department. However, the choice of therapeutic options is currently limited.

Eczema is a complex disorder, resulting from the interplay of multiple genetic, environmental and immunological effects. In 2009 the McLean laboratory & collaborators reported that loss of function mutations in the filaggrin gene (FLG) are associated with increased risk of atopic eczema. Filaggrin is expressed in the outermost layers of skin and this discovery has placed new emphasis on the role of skin barrier function in the pathogenesis of atopic eczema. A fuller understanding of genetic mechanisms in eczema would clarify the pathogenesis of this complex trait and may facilitate the development of novel treatments.

My work aims to identify additional genetic factors affecting FLG expression in human skin and to define other genes involved in the development of childhood eczema and atopic disease.

We have recently shown that FLG mutations significantly increase risk of peanut allergy; this is the first genetic risk factor for peanut allergy that has been confirmed in more than one population. I have also shown that studying copy number variation within the FLG gene contributes to eczema risk in a dose-dependent way, indicating that treatments aimed at increasing filaggrin expression may be useful therapeutically. I am currently using next generation sequencing to investigate the transcriptome of atopic eczema skin, to further define the molecular mechanisms in filaggrin-deficient skin and atopic eczema.

Publications

Guy's and St Thomas' NHS Foundation Trust 2018,

'A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT)' British Journal of Dermatology, vol. 179, no. 6, pp. 1297-1306.
https://doi.org/10.1111/bjd.16717

Research output: Contribution To Journal



Eyerich, K, Brown, SJ, Perez White, BE, Tanaka, RJ, Bissonette, R, Dhar, S, Bieber, T, Hijnen, DJ, Guttman-Yassky, E, Irvine, A, Thyssen, JP, Vestergaard, C, Werfel, T, Wollenberg, A, Paller, AS & Reynolds, NJ 2018,

'Human and computational models of atopic dermatitis: a review and perspectives by an expert panel of the International Eczema Council' Journal of Allergy and Clinical Immunology.
https://doi.org/10.1016/j.jaci.2018.10.033

Research output: Contribution To Journal



Alexander, H, Brown, S, Danby, S & Flohr, C 2018,

'Research Techniques Made Simple: Transepidermal Water Loss Measurement as a Research Tool' Journal of Investigative Dermatology, vol. 138, no. 11, pp. 2295-2300.e1.
https://doi.org/10.1016/j.jid.2018.09.001

Research output: Contribution To Journal



Brown, SJ 2018,

'Research Techniques Are Not Simple' Journal of Investigative Dermatology, vol. 138, no. 10, pp. 2089-2090.
https://doi.org/10.1016/j.jid.2018.07.019

Research output: Contribution To Journal



Harkins, C, Pettigrew, KA, Oravcová, K, Gardner, J, Hearn, RMR, Rice, D, Mather, AE, Parkhill, J, Brown, S, Proby, C & Holden, MTG 2018,

'The micro-evolution and epidemiology of Staphylococcus aureus colonization during atopic eczema disease flare' Journal of Investigative Dermatology, vol. 138, no. 2, pp. 336-343.
https://doi.org/10.1016/j.jid.2017.09.023

Research output: Contribution To Journal



Paternoster, L, Savenije, OEM, Heron, J, Evans, DM, Vonk, JM, Brunekreef, B, Wijga, AH, Henderson, AJ, Koppelman, GH & Brown, SJ 2017,

'Identification of atopic dermatitis subgroups in children from two longitudinal birth cohorts' Journal of Allergy and Clinical Immunology.
https://doi.org/10.1016/j.jaci.2017.09.044

Research output: Contribution To Journal



Simpson, EL, Bruin-Weller, M, Flohr, C, Ardern-Jones, MR, Barbarot, S, Deleuran, M, Bieber, T, Vestergaard, C, Brown, SJ, Cork, MJ, Drucker, AM, Eichenfield, LF, Foelster-Holst, R, Guttman-Yassky, E, Nosbaum, A, Reynolds, NJ, Silverberg, JI, Schmitt, J, Seyger, MMB, Spuls, PI, Stalder, J-F, Su, JC, Takaoka, R, Traidl-Hoffmann, C, Thyssen, JP, van der Schaft, J, Wollenberg, A, Irvine, AD & Paller, AS 2017,

'When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council' Journal of the American Academy of Dermatology, vol. 77, no. 4, pp. 623-633.
https://doi.org/10.1016/j.jaad.2017.06.042

Research output: Contribution To Journal



Foulkes, A & Brown, S 2017,

'Genetic prediction of treatment response in psoriasis is still a work in progress' British Journal of Dermatology, vol. 177, no. 2, pp. 344-345.
https://doi.org/10.1111/bjd.15691

Research output: Contribution To Journal



Chalmers, JR, Haines, RH, Mitchell, EJ, Thomas, KS, Brown, SJ, Ridd, MJ, Lawton, S, Simpson, EL, Cork, MJ, Sach, TH, Bradshaw, LE, Montgomery, AA, Boyle, RJ & Williams, HC 2017,

'Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial' Trials, vol. 18, 343, pp. 1-11.
https://doi.org/10.1186/s13063-017-2031-3

Research output: Contribution To Journal



Brown, SJ 2017,

'What progress have we made in the treatment of atopic eczema? Putting the new biological therapies into a wider context' British Journal of Dermatology, vol. 177, no. 1, pp. 4-6.
https://doi.org/10.1111/bjd.15646

Research output: Contribution To Journal



Brown, SJ 2017,

'Increased filaggrin expression in oral lichenoid lesions: is this cause or effect?' Journal of the European Academy of Dermatology and Venereology, vol. 31, no. 5, pp. 759.
https://doi.org/10.1111/jdv.14265

Research output: Contribution To Journal



Thomas, KS, Bradshaw, LE, Sach, TH, Batchelor, JM, Lawton, S, Harrison, EF, Haines, RH, Ahmed, A, Williams, HC, Dean, T, Burrows, NP, Pollock, I, Llewellyn, J, Crang, C, Grundy, JD, Guiness, J, Gribbin, A, Mitchell, EJ, Cowdell, F, Brown, SJ, Montgomery, AA & UK Dermatology Clinical Trials Network’s CLOTHES Trial Team 2017,

'Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial)' PLo S Medicine, vol. 14, no. 4, e1002280, pp. 1-23.
https://doi.org/10.1371/journal.pmed.1002280

Research output: Contribution To Journal



Naeem, AS, Tommasi, C, Cole, C, Brown, SJ, Zhu, Y, Way, B, Willis Owen, SAG, Moffatt, M, Cookson, WO, Harper, JI, Di, WL, Brown, SJ, Reinheckel, T & O'Shaughnessy, RFL 2017,

'A mechanistic target of rapamycin complex 1/2 (m TORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis' Journal of Allergy and Clinical Immunology, vol. 139, no. 4, pp. 1228-1241.
https://doi.org/10.1016/j.jaci.2016.09.052

Research output: Contribution To Journal



Thomas, KS, Bradshaw, LE, Sach, TH, Cowdell, F, Batchelor, JM, Lawton, S, Harrison, EF, Haines, RH, Ahmed, A, Dean, T, Burrows, NP, Pollock, I, Buckley, HK, Williams, HC, Llewellyn, J, Crang, C, Grundy, JD, Guiness, J, Gribbin, A, Wake, EV, Mitchell, EJ, Brown, SJ & Montgomery, AA 2017,

'Randomised controlled trial of silk therapeutic garments for the management of atopic eczema in children: the CLOTHES trial' Health Technology Assessment, vol. 21, no. 16, pp. 1-260.
https://doi.org/10.3310/hta21160

Research output: Contribution To Journal



Brown, SJ 2017,

'Evidence-based medicine for atopic eczema: identifying the knowns and unknowns' British Journal of Dermatology, vol. 176, no. 4, pp. 842-844.
https://doi.org/10.1111/bjd.15247

Research output: Contribution To Journal



Brown, SJ 2017,

'Molecular mechanisms in atopic eczema: insight gained from genetic studies' Journal of Pathology, vol. 241, no. 2, pp. 140-145.
https://doi.org/10.1002/path.4810

Research output: Contribution To Journal



Forbes, D, Johnston, L, Gardner, J, Mac Callum, SF, Campbell, LE, Dinkova-Kostova, AT, Mc Lean, WHI, Ibbotson, SH, Dawe, RS & Brown, SJ 2016,

'Filaggrin genotype does not determine the skin's threshold to UV-induced erythema' Journal of Allergy and Clinical Immunology, vol. 137, no. 4, pp. 1280-1282.e3.
https://doi.org/10.1016/j.jaci.2015.11.022

Research output: Contribution To Journal



Wedgeworth, E, Glover, M, Irvine, AD, Neri, I, Baselga, E, Clayton, TH, Beattie, PE, Bjerre, JV, Burrows, NP, Foelster-Holst, R, Hedelund, L, Hernandez-Martin, A, Audrain, H, Bhate, K, Brown, SJ, Baryschpolec, S, Darne, S, Durack, A, Dvorakova, V, Gach, J, Goldstraw, N, Goodyear, H, Grabczynska, S, Greenblatt, D, Halpern, J, Hearn, RMR, Hoey, S, Hughes, B, Jayaraj, R, Johansson, EK, Lam, M, Leech, S, O'Regan, GM, Morrison, D, Porter, W, Ramesh, R, Schill, T, Shaw, L, Taylor, AEM, Taylor, R, Thomson, J, Tiffin, P, Tsakok, M, Janmohamed, SR, Laguda, B, Mc Pherson, T, Oranje, AP, Patrizi, A, Ravenscroft, JC, Shahidullah, H, Solman, L, Svensson, A, Wahlgren, CF, Hoeger, PH & Flohr, C 2016,

'Propranolol in the treatment of infantile haemangiomas: lessons from the European Propranolol In the Treatment of Complicated Haemangiomas (PITCH) Taskforce survey' British Journal of Dermatology, vol. 174, no. 3, pp. 594-601.
https://doi.org/10.1111/bjd.14233

Research output: Contribution To Journal



Brown, SJ 2016,

'Atopic eczema' Clinical Medicine - Journal of the Royal College of Physicians of London, vol. 16, no. 1, pp. 66-69.
https://doi.org/10.7861/clinmedicine.16-1-66

Research output: Contribution To Journal



Brown, SJ 2016,

'Hand dermatitis in construction workers: a lesson in genetic epidemiology' British Journal of Dermatology, vol. 174, no. 2, pp. 263-265.
https://doi.org/10.1111/bjd.14380

Research output: Contribution To Journal



2015,

'Erratum: Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms' American Journal of Human Genetics, vol. 97, no. 6, pp. 933.
https://doi.org/10.1016/j.ajhg.2015.10.018

Research output: Contribution To Journal



Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, DP, Curtin, JA, Bønnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, AC, Thyssen, JP, Den Dekker, HT, Ferreira, MA, Altmaier, E, Sleiman, PMA, Xiao, FL, Gonzalez, JR, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, CJ, Carstensen, L, Groen-Blokhuis, MM, Venturini, C, Pennell, CE, Barton, SJ, Levin, AM, Curjuric, I, Bustamante, M, Kreiner-Møller, E, Lockett, GA, Bacelis, J, Bunyavanich, S, Myers, RA, Matanovic, A, Kumar, A, Tung, JY, Hirota, T, Kubo, M, Mc Ardle, WL, Henderson, AJ, Kemp, JP, Zheng, J, Smith, GD, Rüschendorf, F, Bauerfeind, A, Lee-Kirsch, MA, Arnold, A, Homuth, G, Schmidt, CO, Mangold, E, Cichon, S, Keil, T, Rodríguez, E, Peters, A, Franke, A, Lieb, W, Novak, N, Fölster-Holst, R, Horikoshi, M, Pekkanen, J, Sebert, S, Husemoen, LL, Grarup, N, De Jongste, JC, Rivadeneira, F, Hofman, A, Jaddoe, VWV, Pasmans, SGMA, Elbert, NJ, Uitterlinden, AG, Marks, GB, Thompson, PJ, Matheson, MC, Robertson, CF, Ried, JS, Li, J, Zuo, XB, Zheng, XD, Yin, XY, Sun, LD, Mc Aleer, MA, O'Regan, GM, Fahy, CMR, Campbell, LE, Macek, M, Kurek, M, Hu, D, Eng, C, Postma, DS, Feenstra, B, Geller, F, Hottenga, JJ, Middeldorp, CM, Hysi, P, Bataille, V, Spector, T, Tiesler, CMT, Thiering, E, Pahukasahasram, B, Yang, JJ, Imboden, M, Huntsman, S, Vilor-Tejedor, N, Relton, CL, Myhre, R, Nystad, W, Custovic, A, Weiss, ST, Meyers, DA, Söderhäll, C, Melén, E, Ober, C, Raby, BA, Simpson, A, Jacobsson, B, Holloway, JW, Bisgaard, H, Sunyer, J, Probst-Hensch, NM, Williams, LK, Godfrey, KM, Wang, CA, Boomsma, DI, Melbye, M, Koppelman, GH, Jarvis, D, Mc Lean, WHI, Irvine, AD, Zhang, XJ, Hakonarson, H, Gieger, C, Burchard, EG, Martin, NG, Duijts, L, Linneberg, A, Jarvelin, MR, Nöthen, MM, Lau, S, Hübner, N, Lee, YA, Tamari, M, Hinds, DA, Glass, D, Brown, SJ, Heinrich, J, Evans, DM & Weidinger, S 2015,

'Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis' Nature Genetics, vol. 47, no. 12, pp. 1449-1456.
https://doi.org/10.1038/ng.3424

Research output: Contribution To Journal



Healy, E, Brown, SJ, Langan, SM, Nicholls, SG, Shams, K & Reynolds, NJ 2015,

'Identification of translational dermatology research priorities in the U.K. Results of an electronic Delphi exercise' British Journal of Dermatology, vol. 173, no. 5, pp. 1191-1198.
https://doi.org/10.1111/bjd.14022

Research output: Contribution To Journal



Harrison, EF, Haines, RH, Cowdell, F, Sach, TH, Dean, T, Pollock, I, Burrows, NP, Buckley, H, Batchelor, J, Williams, HC, Lawton, S, Brown, SJ, Bradshaw, LE, Ahmed, A, Montgomery, AA, Mitchell, EJ & Thomas, KS 2015,

'A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial' Trials, vol. 16, 390.
https://doi.org/10.1186/s13063-015-0921-9

Research output: Contribution To Journal



Harkins, CP, Waters, A, Kerr, A, Campbell, L, Mc Lean, WHI, Brown, SJ & Ibbotson, SH 2015,

'Loss-of-function mutations in the gene encoding filaggrin are not strongly associated with chronic actinic dermatitis' Journal of Investigative Dermatology, vol. 135, no. 7, pp. 1919-1921.
https://doi.org/10.1038/jid.2015.64

Research output: Contribution To Journal



O'Shaughnessy, RFL & Brown, SJ 2015,

'Insight from the air-skin interface' Journal of Investigative Dermatology, vol. 135, no. 2, pp. 331-333.
https://doi.org/10.1038/jid.2014.457

Research output: Contribution To Journal



Baurecht, H, Hotze, M, Brand, S, Büning, C, Cormican, P, Corvin, A, Ellinghaus, D, Ellinghaus, E, Esparza-Gordillo, J, Fölster-Holst, R, Franke, A, Gieger, C, Hubner, N, Illig, T, Irvine, AD, Kabesch, M, Lee, YAE, Lieb, W, Marenholz, I, Mc Lean, WHI, Morris, DW, Mrowietz, U, Nair, R, Nöthen, MM, Novak, N, O'Regan, GM, PAGE Consortium, Schreiber, S, Smith, C, Strauch, K, Stuart, PE, Trembath, R, Tsoi, LC, Weichenthal, M, Barker, J, Elder, JT, Weidinger, S, Cordell, HJ & Brown, SJ 2015,

'Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms' American Journal of Human Genetics, vol. 96, no. 1, pp. 104-120.
https://doi.org/10.1016/j.ajhg.2014.12.004

Research output: Contribution To Journal



Brough, HA, Liu, AH, Sicherer, S, Makinson, K, Douiri, A, Brown, SJ, Stephens, AC, Mc Lean, WHI, Turcanu, V, Wood, RA, Jones, SM, Burks, W, Dawson, P, Stablein, D, Sampson, H & Lack, G 2015,

'Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy' Journal of Allergy and Clinical Immunology, vol. 135, no. 1, pp. 164-170.e4.
https://doi.org/10.1016/j.jaci.2014.10.007

Research output: Contribution To Journal



Brough, HA, Simpson, A, Makinson, K, Hankinson, J, Brown, S, Douiri, A, Belgrave, DCM, Penagos, M, Stephens, AC, Mc Lean, WHI, Turcanu, V, Nicolaou, N, Custovic, A & Lack, G 2014,

'Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations' Journal of Allergy and Clinical Immunology, vol. 134, no. 4, pp. 867-875.e1.
https://doi.org/10.1016/j.jaci.2014.08.011

Research output: Contribution To Journal



Simpson, EL, Chalmers, JR, Hanifin, JM, Thomas, KS, Cork, MJ, Mc Lean, WHI, Brown, SJ, Chen, Z, Chen, Y & Williams, HC 2014,

'Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention' Journal of Allergy and Clinical Immunology, vol. 134, no. 4, pp. 818-823.
https://doi.org/10.1016/j.jaci.2014.08.005

Research output: Contribution To Journal



Cole, C, Kroboth, K, Schurch, NJ, Sandilands, A, Sherstnev, A, O'Regan, GM, Watson, RM, Mc Lean, WHI, Barton, GJ, Irvine, AD & Brown, SJ 2014,

'Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis' Journal of Allergy and Clinical Immunology, vol. 134, no. 1, pp. 82-91.
https://doi.org/10.1016/j.jaci.2014.04.021

Research output: Contribution To Journal



Schurch, NJ, Cole, C, Sherstnev, A, Song, J, Duc, C, Storey, KG, Mc Lean, WHI, Brown, SJ, Simpson, GG & Barton, GJ 2014,

'Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs' PLo S ONE, vol. 9, no. 4, e94270.
https://doi.org/10.1371/journal.pone.0094270

Research output: Contribution To Journal



Thawer-Esmail, F, Jakasa, I, Todd, G, Wen, Y, Brown, SJ, Kroboth, K, Campbell, LE, O'Regan, GM, Mc Lean, WHI, Irvine, AD, Kezic, S & Sandilands, A 2014,

'South African ama Xhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin' Journal of Allergy and Clinical Immunology, vol. 133, no. 1, pp. 280-282.e1-e2.
https://doi.org/10.1016/j.jaci.2013.09.053

Research output: Contribution To Journal



Pohler, E, Zamiri, M, Harkins, C, Salas-Alanis, JC, Perkins, W, Smith, FJD, Mc Lean, WHI & Brown, SJ 2013,

'Heterozygous mutations in AAGAB cause type 1 punctate palmoplantar keratoderma with evidence for increased growth factor signaling' Journal of Investigative Dermatology, vol. 133, no. 12, pp. 2805-2808.
https://doi.org/10.1038/jid.2013.243

Research output: Contribution To Journal



Weidinger, S, Willis-Owen, SAG, Kamatani, Y, Baurecht, H, Morar, N, Liang, L, Edser, P, Street, T, Rodriguez, E, O'Regan, GM, Beattie, P, Fölster-Holst, R, Franke, A, Novak, N, Fahy, CM, Winge, MCG, Kabesch, M, Illig, T, Heath, S, Söderhäll, C, Melén, E, Pershagen, G, Kere, J, Bradley, M, Lieden, A, Nordenskjold, M, Harper, JI, Mc Lean, WHI, Brown, SJ, Cookson, WOC, Lathrop, GM, Irvine, AD & Moffatt, MF 2013,

'A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis' Human Molecular Genetics, vol. 22, no. 23, pp. 4841-4856.
https://doi.org/10.1093/hmg/ddt317

Research output: Contribution To Journal



Saunders, SP, Goh, CSM, Brown, SJ, Palmer, CNA, Porter, RM, Cole, C, Campbell, LE, Gierlinski, M, Barton, GJ, Schneider, G, Balmain, A, Prescott, AR, Weidinger, S, Baurecht, H, Kabesch, M, Gieger, C, Lee, Y-A, Tavendale, R, Mukhopadhyay, S, Turner, SW, Madhok, VB, Sullivan, FM, Relton, C, Burn, J, Meggitt, S, Smith, CH, Allen, MA, Barker, JNWN, Reynolds, NJ, Cordell, HJ, Irvine, AD, Mc Lean, WHI, Sandilands, A & Fallon, PG 2013,

'Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects' Journal of Allergy and Clinical Immunology, vol. 132, no. 5, pp. 1121-1129.
https://doi.org/10.1016/j.jaci.2013.08.046

Research output: Contribution To Journal



Brown, S 2013,

'The pharmacogenetics of body odor: as easy as ABCC?' Journal of Investigative Dermatology, vol. 133, no. 7, pp. 1709-1711.
https://doi.org/10.1038/jid.2013.14

Research output: Contribution To Journal



Ellinghaus, D, Baurecht, H, Esparza-Gordillo, J, Rodríguez, E, Matanovic, A, Marenholz, I, Hübner, N, Schaarschmidt, H, Novak, N, Michel, S, Maintz, L, Werfel, T, Meyer-Hoffert, U, Hotze, M, Prokisch, H, Heim, K, Herder, C, Hirota, T, Tamari, M, Kubo, M, Takahashi, A, Nakamura, Y, Tsoi, LC, Stuart, P, Elder, JT, Sun, L, Zuo, X, Yang, S, Zhang, X, Hoffmann, P, Nöthen, MM, Fölster-Holst, R, Winkelmann, J, Illig, T, Boehm, BO, Duerr, RH, Büning, C, Brand, S, Glas, J, Mc Aleer, MA, Fahy, CM, Kabesch, M, Brown, S, Mc Lean, WHI, Irvine, AD, Schreiber, S, Lee, Y-A, Franke, A & Weidinger, S 2013,

'High-density genotyping study identifies four new susceptibility loci for atopic dermatitis' Nature Genetics, vol. 45, no. 7, pp. 808-812.
https://doi.org/10.1038/ng.2642

Research output: Contribution To Journal



Asai, Y, Greenwood, C, Hull, PR, Alizadehfar, R, Ben-Shoshan, M, Brown, SJ, Campbell, L, Michel, DL, Bussières, J, Rousseau, F, Fujiwara, TM, Morgan, K, Irvine, AD, Mc Lean, WHI & Clarke, A 2013,

'Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status' Journal of Allergy and Clinical Immunology, vol. 132, no. 1, pp. 239-242.e7.
https://doi.org/10.1016/j.jaci.2013.03.043

Research output: Contribution To Journal



Goh, CS, Saunders, SP, Cole, C, Weidinger, S, Baurecht, H, Lee, Y, Reynolds, NJ, Barker, JN, Cordell, HJ, Brown, SJ, Irvine, AD, Mc Lean, I, Sandilands, A & Fallon, PG 2013,

'A nonsense mutation in the mattrin gene causes the matted mouse phenotype and is a predisposing gene for atopic dermatitis in humans' Journal of Investigative Dermatology, vol. 133, no. S1, 854, pp. S145.
https://doi.org/10.1038/jid.2013.100

Research output: Contribution To Journal



Pohler, E, Harkins, C, Salas, J, Zamiri, M, Wilson, NJ, Smith, FJ, Brown, SJ & Mc Lean, I 2013,

'Heterozygous loss-of-function mutations in the AAGAB gene cause punctate palmoplantar keratoderma type 1 and impair receptor tyrosine kinase protein turnover' Journal of Investigative Dermatology, vol. 133, no. S1, 863, pp. S146.
https://doi.org/10.1038/jid.2013.100

Research output: Contribution To Journal



Pohler, E, Mamai, O, Hirst, J, Zamiri, M, Horn, H, Nomura, T, Irvine, AD, Moran, B, Wilson, NJ, Smith, FJD, Goh, CSM, Sandilands, A, Cole, C, Barton, GJ, Evans, AT, Shimizu, H, Akiyama, M, Suehiro, M, Konohana, I, Shboul, M, Teissier, S, Boussofara, L, Denguezli, M, Saad, A, Gribaa, M, Dopping-Hepenstal, PJ, Mc Grath, JA, Brown, SJ, Goudie, DR, Reversade, B, Munro, CS & Mc Lean, WHI 2012,

'Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma' Nature Genetics, vol. 44, no. 11, pp. 1272-1276.
https://doi.org/10.1038/ng.2444

Research output: Contribution To Journal



Sandilands, A, Brown, SJ, Goh, CS, Pohler, E, Wilson, NJ, Campbell, LE, Miyamoto, K, Kubo, A, Irvine, AD, Thawer-Esmail, F, Munro, CS, Mc Lean, WHI, Kudoh, J, Amagai, M & Matsui, T 2012,

'Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin' Journal of Investigative Dermatology, vol. 132, no. 5, pp. 1507-1510.
https://doi.org/10.1038/jid.2011.479

Research output: Contribution To Journal



Brown, SJ & Mc Lean, WHI 2012,

'One remarkable molecule: filaggrin' Journal of Investigative Dermatology, vol. 132, no. 3, pp. 751-762.
https://doi.org/10.1038/jid.2011.393

Research output: Contribution To Journal



Brown, SJ, Kroboth, K, Sandilands, A, Campbell, LE, Pohler, E, Kezic, S, Cordell, HJ, Mc Lean, WHI & Irvine, AD 2012,

'Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect' Journal of Investigative Dermatology, vol. 132, no. 1, pp. 98-104.
https://doi.org/10.1038/jid.2011.342

Research output: Contribution To Journal



Chen, H, Common, JEA, Haines, RL, Balakrishnan, A, Brown, SJ, Goh, CSM, Cordell, HJ, Sandilands, A, Campbell, LE, Kroboth, K, Irvine, AD, Goh, DLM, Tang, MBY, van Bever, HP, Giam, YC, Mc Lean, WHI & Lane, EB 2011,

'Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations' British Journal of Dermatology, vol. 165, no. 1, pp. 106-114.
https://doi.org/10.1111/j.1365-2133.2011.10331.x

Research output: Contribution To Journal



Common, JEA, Brown, SJ, Haines, RL, Goh, CSM, Chen, H, Balakrishnan, A, Munro, CS, Tan, AWH, Tan, HH, Tang, MBY & Lane, EB 2011,

'Filaggrin null mutations are not a protective factor for acne vulgaris' Journal of Investigative Dermatology, vol. 131, no. 6, pp. 1378-1380.
https://doi.org/10.1038/jid.2011.23

Research output: Contribution To Journal



Brown, SJ, Kroboth, K, Sandilands, A, Campbell, LE, Pohler, E, Irvine, AD, Cordell, HJ & Mc Lean, W 2011,

'Copy number variation within the filaggrin gene contributes to risk of atopic dermatitis' Journal of Investigative Dermatology, vol. 131, no. Supplement 1, 375, pp. S63-S63.
https://doi.org/10.1038/jid.2011.75

Research output: Contribution To Journal



Brown, SJ, Asai, Y, Cordell, HJ, Campbell, LE, Zhao, Y, Liao, H, Northstone, K, Henderson, J, Alizadehfar, R, Ben-Shoshan, M, Morgan, K, Roberts, G, Masthoff, LJN, Pasmans, SGMA, van den Akker, PC, Wijmenga, C, Hourihane, JOB, Palmer, CNA, Lack, G, Clarke, A, Hull, PR, Irvine, AD & Mc Lean, WHI 2011,

'Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy' Journal of Allergy and Clinical Immunology, vol. 127, no. 3, pp. 661-667.
https://doi.org/10.1016/j.jaci.2011.01.031

Research output: Contribution To Journal



Brown, SJ & Watson, R 2011,

Neonatal Lupus Erythematosus. in AD Irvine, PH Hoeger & AC Yan (eds), Harper's Textbook of Pediatric Dermatology. 3rd edn, vol. 1, Oxford, pp. 1-12.
https://doi.org/10.1002/9781444345384.ch44

Research output: Contribution To Book Anthology



Brown, SJ, O'Regan, GM, Campbell, LE, Cordell, HJ, Irvine, AD & Mc Lean, WHI 2010,

'Replication of eczema susceptibility loci identified from a genome-wide association study' British Journal of Dermatology, vol. 162, no. 4, O30, pp. 925-925.
https://doi.org/10.1111/j.1365-2133.2010.09700.x

Research output: Contribution To Journal



O'Regan, GM, Campbell, LE, Cordell, HJ, Irvine, AD, Mc Lean, WHI & Brown, SJ 2010,

'Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations' Journal of Allergy and Clinical Immunology, vol. 125, no. 1, pp. 170-174.e2.
https://doi.org/10.1016/j.jaci.2009.10.046

Research output: Contribution To Journal



Brown, SJ, Maoldomhnaigh, CO, Scanlan, BT, O'Sullivan, M, Mc Mahon, C, Irvine, AD, Watson, RM & Butler, K 2010,

'A case of haemophagocytic lymphohistiocytosis: role of skin biopsy in the diagnosis' British Journal of Dermatology, vol. 162, no. 5, pp. 1163-1163.
https://doi.org/10.1111/j.1365-2133.2010.09683.x

Research output: Contribution To Journal



Brown, SJ, Maoldomhnaigh, CO, Scanlan, BT, O'Sullivan, M, Mc Mahon, C, Irvine, AD, Watson, RM & Butler, K 2010,

'A case of haemophagocytic lymphohistiocytosis: role of skin biopsy in the diagnosis' Paper presented at British Society for Paediatric Dermatology 24th Annual Symposium, London, United Kingdom, 6/11/10 - 7/11/10, .

Research output: Contribution To Conference



Brown, SJ, Relton, CL, Liao, H, Zhao, Y, Sandilands, A, Mc Lean, WHI, Cordell, HJ & Reynolds, NJ 2009,

'Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children' British Journal of Dermatology, vol. 161, no. 4, pp. 884-889.
https://doi.org/10.1111/j.1365-2133.2009.09339.x

Research output: Contribution To Journal



Van Limbergen, J, Russell, RK, Nimmo, ER, Zhao, Y, Liao, H, Drummond, HE, Davies, G, Gillett, PM, Mc Grogan, P, Bisset, WM, Mahdi, G, Wilson, DC, Brown, SJ, Mc Lean, WHI & Satsangi, J 2009,

'Filaggrin loss-of-function variants are associated with atopic comorbidity in pediatric inflammatory bowel disease' Inflammatory Bowel Diseases, vol. 15, no. 10, pp. 1492-1498.
https://doi.org/10.1002/ibd.20926

Research output: Contribution To Journal



Rodriguez, E, Baurecht, H, Herberich, E, Wagenpfeil, S, Brown, SJ, Cordell, HJ, Irvine, AD & Weidinger, S 2009,

'Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease' Journal of Allergy and Clinical Immunology, vol. 123, no. 6, pp. 1361-1370.e7.
https://doi.org/10.1016/j.jaci.2009.03.036

Research output: Contribution To Journal



Basu, A, Brown, S, Kirkham, N, Ramesh, V, Leech, S & Devlin, A 2009,

'Coma blisters in 2 children on anticonvulsant medication.' Journal of Child Neurology, vol. 24, no. 8, pp. 1021-1025.
https://doi.org/10.1177/0883073809332771

Research output: Contribution To Journal



Brown, SJ & Mc Lean, WHI 2009,

'Eczema genetics: current state of knowledge and future goals' Journal of Investigative Dermatology, vol. 129, no. 3, pp. 543-552.
https://doi.org/10.1038/jid.2008.413

Research output: Contribution To Journal



Brown, SJ, Sandilands, A, Zhao, Y, Liao, H, Relton, CL, Meggitt, SJ, Reynolds, NJ, Barker, JNWN, Trembath, RC, Cordell, HJ & Mc Lean, WHI 2008,

'Additional filaggrin polymorphisms in early-onset and persistent atopic eczema' British Journal of Dermatology, vol. 159, no. 6, P4, pp. 1241-1242.
https://doi.org/10.1111/j.1365-2133.2008.08883.x

Research output: Contribution To Journal



Brown, S, Relton, C, Liao, H, Zhao, Y, Sandilands, A, Burn, J, Cordell, H, Mc Lean, WHI & Reynolds, N 2008,

'Filaggrin mutations in atopic eczema: genotype-phenotype correlation' British Journal of Dermatology, vol. 159, no. Supplement s1, pp. 11-11.
https://doi.org/10.1111/j.1365-2133.2008.08537.x

Research output: Contribution To Journal



Brown, SJ, Sandilands, A, Zhao, Y, Liao, H, Relton, CL, Meggitt, SJ, Trembath, RC, Barker, JNWN, Reynolds, NJ, Cordell, HJ & Mc Lean, WHI 2008,

'Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema' Journal of Investigative Dermatology, vol. 128, no. 6, pp. 1591-1594.
https://doi.org/10.1038/sj.jid.5701206

Research output: Contribution To Journal



Brown, SJ & Irvine, AD 2008,

'Atopic eczema and the filaggrin story' Seminars in Cutaneous Medicine and Surgery, vol. 27, no. 2, pp. 128-137.
https://doi.org/10.1016/j.sder.2008.04.001

Research output: Contribution To Journal



Brown, S & Cordell, HJ 2008,

'Are filaggrin mutations associated with hand eczema or contact allergy? we do not know' British Journal of Dermatology, vol. 158, no. 6, pp. 1383-1384.
https://doi.org/10.1111/j.1365-2133.2008.08551.x

Research output: Contribution To Journal



Brown, SJ, Relton, CL, Liao, H, Zhao, Y, Sandilands, A, Wilson, IJ, Burn, J, Reynolds, NJ, Mc Lean, WHI & Cordell, HJ 2008,

'Filaggrin null mutations and childhood atopic eczema: a population-based case-control study' Journal of Allergy and Clinical Immunology, vol. 121, no. 4, pp. 940-946.e3.
https://doi.org/10.1016/j.jaci.2008.01.013

Research output: Contribution To Journal



Brown, S, Relton, CL, Liao, H, Zhao, Y, Sandilands, A, Wilson, IJ, Burn, J, Reynolds, NJ, Mc Lean, W & Cordell, HJ 2008,

'Filaggrin null mutations in mild-moderate atopic eczema: a population-based case-control study' Journal of Investigative Dermatology, vol. 128, no. S1, 670, pp. S112-S112.

Research output: Contribution To Journal



Brown, SJ, Kirkham, N, Devlin, AM & Leech, SN 2008,

'Coma-associated bullae and eccrine sweat gland necrosis in a 9-year-old boy' British Journal of Dermatology, vol. 159, no. 6, pp. 1236-1236.
https://doi.org/10.1111/j.1365-2133.2008.08883.x

Research output: Contribution To Journal



Brown, S, Talks, SJ, Needham, SJ & Taylor, AEM 2007,

'Pseudoxanthoma elasticum: biopsy of clinically normal skin in the investigation of patients with angioid streaks' British Journal of Dermatology, vol. 157, no. 4, pp. 748-751.
https://doi.org/10.1111/j.1365-2133.2007.08076.x

Research output: Contribution To Journal



Brown, SJ, Kirkham, N, Devlin, AM & Leech, SN 2007,

'Coma-associated bullae and eccrine sweat gland necrosis in a 9-year-old boy' Paper presented at British Society for Paediatric Dermatology 22nd Annual Symposium, London, United Kingdom, 16/11/07 - 16/11/07, .

Research output: Contribution To Conference



Brown, SJ, Talks, SJ, Needham, SJ & Taylor, AEM 2006,

'Does biopsy of clinically normal skin facilitate the diagnosis of pseudoxanthoma etasticum?' British Journal of Dermatology, vol. 155, no. Supplement s1, P-58, pp. 47-47.
https://doi.org/10.1111/j.1365-2133.2006.07253.x

Research output: Contribution To Journal



Brown, SJ & Lawrence, CM 2006,

'The management of skin malignancy: to what extent should we rely on clinical diagnosis? ' British Journal of Dermatology, vol. 155, no. 1, pp. 100-103.
https://doi.org/10.1111/j.1365-2133.2006.07307.x

Research output: Contribution To Journal



Brown, S & Reynolds, NJ 2006,

'Atopic and non-atopic eczema' BMJ, vol. 332, no. 584, pp. 584-588.
https://doi.org/10.1136/bmj.332.7541.584

Research output: Contribution To Journal



Brown, SJ, Leech, SN, Eccleston, FJ & Taylor, AEM 2006,

'Appointment of a paediatric eczema nurse reduces inpatient admissions for atopic eczema' British Journal of Dermatology, vol. 155, no. Suppl. 1, pp. 106-106.
https://doi.org/10.1111/j.1365-2133.2006.07258_1.x

Research output: Contribution To Journal



Brown, SJ, Jackson, GH, Reynolds, NJ & Lawrence, CM 2006,

'Chronic cutaneous graft-versus-host disease associated with multiple cutaneous squamous cell carcinomas' Clinical and Experimental Dermatology, vol. 31, no. 3, pp. 472-473.
https://doi.org/10.1111/j.1365-2230.2006.02109.x

Research output: Contribution To Journal



Brown, SJ, Thirlaway, CJ & Lawrence, CM 2005,

'A 6-month prospective study of the incidence and management of dermatological malignancies in an NHS teaching hospital' British Journal of Dermatology, vol. 153, no. Suppl. 1, DS-1, pp. 74-74.
https://doi.org/10.1111/j.1365-2133.2005.06654.x

Research output: Contribution To Journal



Brown, SJ, Barrett, PD, Hendrick, A & Langtry, JAA 2003,

'Subcorneal pustular dermatosis in association with chronic lymphocytic leukaemia' Acta Dermato-Venereologica, vol. 83, no. 4, pp. 306-307.
https://doi.org/10.1080/00015550310016661

Research output: Contribution To Journal



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Activities

British Society for Paediatric Dermatology 24th Annual Symposium

Role: Participant
Activity: Participation in conference

6 11 2010

British Society for Paediatric Dermatology 22nd Annual Symposium

Role: Participant
Activity: Participation in conference

16 11 2007