Peter Donnan is Professor of Epidemiology and Biostatistics in the Medical School Division of Population Health Sciences within the Medical Research Institute, University of Dundee. He has 30 years’ experience in the design and analysis of Health Services and Population Research observational studies as well as randomised controlled trials of drugs (steroids in Bell’s Palsy, NEJM, 2007) as well as public health interventions (screening for breast cancer, The Lancet, 1990, Football Fans In Training, The Lancet, 2014) and informatics (DQIP, NEJM 2016).
He leads the Dundee Epidemiology and Biostatistics Unit (DEBU) and co-leads the Tayside Clinical Trials Unit (TCTU) which has UKCRC registration and successfully runs 30 clinical trials with income of approximately £3M per year. He has also carried out extensive population record-linkage research on drug safety, adherence and management of long term conditions using Tayside’s and Scotland’s unique prescribing population databases and is the author of over 200 publications (h-index 48, m-index 1.42), as well as an investigator on research projects to a total of over £32 million.
He has developed a number of prognostic algorithms, most notably predicting Coronary Heart Disease (CHD) in people with type 2 diabetes (Diabetes Care, 2006), and Chief Scientist Office funded algorithm to predict risk of emergency admissions in primary care (PEONY) with a view to developing cost-effective interventions for long term conditions (Archives Internal Medicine, 2008). An NIHR HTA-funded study has developed aids to clinical decision making with abnormal liver function tests in primary care. He is senior author of a study to predict outcomes for those admitted to hospital with Acute Pancreatitis using health informatics across Scotland.
He has supervised 16 PhD and MSc students and externally examined PhD theses across the UK. He has developed Master’s level modules in clinical trials and provides a record linkage analysis module for the Dundee MPH (15 students) as well as the Scottish-wide Stratified Medicine and Pharmacological Innovation MSc (35 students).
In 2004, Prof. Donnan was invited to become a member of the New Drugs Committee of the Scottish Medicines Consortium which seeks to advise Area and Drug Therapeutics Committees across Scotland regarding the cost-effectiveness of new drugs and continues in this work with expertise in indirect comparisons, missing data and survival analysis in trials.
'Increased Mortality and Morbidity in Patients with Chronic Hypoparathyroidism: A population based study' Clinical Endocrinology.
'Exposure to contrast media in the perioperative period confers no additional risk of acute kidney injury in surgical patients' Nephrology Dialysis Transplantation, vol. 33, no. 10, gfx325, pp. 1-6.
'Abdominal massage plus advice, compared with advice only, for neurogenic bowel dysfunction in MS: a RCT' Health Technology Assessment, vol. 22, no. 58, pp. 1-134.
'Effect of two different participant information sheets on recruitment to a falls trial: An embedded randomised recruitment trial' Clinical Trials.
'Texting to Reduce Alcohol Misuse (TRAM): main findings from a randomized controlled trial of a text message intervention to reduce binge drinking among disadvantaged men' Addiction, vol. 113, no. 9, pp. 1609-1618.
'Association between objectively measured physical activity and opioid, hypnotic, or anticholinergic medication use in older people – data from the Physical Activity Cohort Scotland study' Drugs & Aging, vol. 35, no. 9, pp. 835-842.
'Amputation-free survival in 17,353 people at high risk for foot ulceration in diabetes: a national observational study' Diabetologia.
'Development and preliminary testing of a brief clinical tool to enable daily monitoring of chemotherapy toxicity: The Daily Chemotherapy Toxicity self-Assessment Questionnaire' European Journal of Cancer Care.
'Risk of Acute Kidney Injury following community prescription of antibiotics: self-controlled case series' Nephrology Dialysis Transplantation.
'Cognitive behavioural therapy with optional graded exercise therapy in patients with severe fatigue with myotonic dystrophy type 1: a multicentre, single-blind, randomised trial' Lancet Neurology.
'Association of opioid prescribing practices with chronic pain and benzodiazepine co-prescription: a primary care data linkage study' British Journal of Anaesthesia, vol. 120, no. 6, pp. 1345-1355.
'Plasma essential fatty acids, cigarette smoking, and dietary antioxidants in peripheral arterial disease - A population-based case-control study' Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 14, no. 3, pp. 471-478.
'A Population-based study of the Epidemiology of Chronic Hypoparathyroidism' Journal of Bone and Mineral Research, vol. 33, no. 3, pp. 478-485.
'Leucine and ACE inhibitors as therapies for sarcopenia (LACE trial): study protocol for a randomised controlled trial' Trials, vol. 19, 6, pp. 1-11.
'Has primary care antimicrobial use really been increasing? Comparison of changes in different prescribing measures for a complete geographic population 1995-2014' Journal of Antimicrobial Chemotherapy, vol. 72, no. 10, pp. 2921-2930.
'Art participation for psychosocial wellbeing during stroke rehabilitation: a feasibility randomised controlled trial' Disability and Rehabilitation.
'Temporal changes in frequency of severe hypoglycemia treated by emergency medical services in types 1 and 2 diabetes: a population-based data-linkage cohort study' Clinical Diabetes and Endocrinology, vol. 3, 7, pp. 1-8.
'Factors associated with change in objectively measured physical activity in older people: data from the Physical Activity Cohort Scotland study' BMC Geriatrics, vol. 17, 180, pp. 1-9.
'Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: Systematic review and meta-analysis' BMC Nephrology, vol. 18, no. 1, 256.
'Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial' The Lancet Diabetes and Endocrinology, vol. 5, no. 8, pp. 597-609.
'The PRECIS-2 tool has good interrater reliability and reasonable discriminant validity' Journal of Clinical Epidemiology, vol. 88, pp. 113-121.
'Epidemiology and outcomes of people with dementia, delirium and unspecified cognitive impairment in the general hospital: prospective cohort study of 10,014 admissions' BMC Medicine, vol. 15, 140, pp. 1-12.
'The e SMART study protocol: a randomised controlled trial to evaluate electronic symptom management using the advanced symptom management system (ASy MS) remote technology for patients with cancer' BMJ Open, vol. 7, no. 5, e015016, pp. 1-10.
'Association between bisphosphonate therapy and outcomes from rehabilitation in older people' Archives of Gerontology and Geriatrics, vol. 70, pp. 195-200.
'Metformin in adults with type 1 diabetes: Design and methods of REducing with Metf Ormin Vascular Adverse Lesions (REMOVAL): An international multicentre trial' Diabetes, Obesity and Metabolism, vol. 19, no. 4, pp. 509-516.
'Abdominal massage for neurogenic bowel dysfunction in people with multiple sclerosis (AMBER - Abdominal Massage for Bowel Dysfunction Effectiveness Research): study protocol for a randomised controlled trial' Trials, vol. 18, 150, pp. 1-9.
'Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study' BMC Medicine, vol. 15, 18.
'Achieving Good Outcomes for Asthma Living (GOAL): mixed methods feasibility and pilot cluster randomised controlled trial of a practical intervention for eliciting, setting and achieving goals for adults with asthma' Trials, vol. 17, 584, pp. 1-17.
'Respiratory effect of beta-blocker eye drops in asthma: population-based study and meta-analysis of clinical trials' British Journal of Clinical Pharmacology, vol. 82, no. 3, pp. 814-822.
'Slower Decline in C-Reactive Protein after an Inflammatory Insult Is Associated with Longer Survival in Older Hospitalised Patients' PLo S ONE, vol. 11, no. 7, e0159412.
'Identifying risk factors for progression to critical care admission and death among individuals with acute pancreatitis: a record linkage analysis of Scottish healthcare databases' BMJ Open, vol. 6, no. 6, e011474, pp. 1-15.
'Spironolactone for people aged 70 or over with osteoarthritic knee pain: a proof-of-concept trial' Arthritis Care & Research, vol. 68, no. 5, pp. 716-721.
'Safer Prescribing: A Trial of Education, Informatics, and Financial Incentives' New England Journal of Medicine, vol. 374, no. 11, pp. 1053-1064.
'Association between allopurinol use and hip fracture in older patients' Bone, vol. 84, pp. 189-193.
'Long-term lithium and estimated glomerular filtration rate - Authors' reply' Lancet Psychiatry, vol. 3, no. 2, pp. 106-7.
'Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension' Aging Clinical and Experimental Research, vol. 29, no. 5, pp. 1055-1059.
'Long-term effect of lithium maintenance therapy on estimated glomerular filtration rate in patients with affective disorders: a population-based cohort study' Lancet Psychiatry, vol. 2, no. 12, pp. 1075-1083.
'Risk of postoperative acute kidney injury in patients undergoing orthopaedic surgery—development and validation of a risk score and effect of acute kidney injury on survival: observational cohort study' BMJ, vol. 351, h5639.
'Bad apples or spoiled barrels? Multilevel modelling analysis of variation in high-risk prescribing in Scotland between general practitioners and between the practices they work in' BMJ Open, vol. 5, no. 11, e008270.
'Association between kidney function, rehabilitation outcome, and survival in older patients discharged from inpatient rehabilitation' American Journal of Kidney Diseases, vol. 66, no. 5, pp. 768-774.
'Construction of a linked health and social care database resource: lessons on process, content and culture' Informatics for Health and Social Care, vol. 40, no. 3, pp. 229-239.
'Time series analysis of the impact of an intervention in Tayside, Scotland to reduce primary care broad-spectrum antimicrobial use' Journal of Antimicrobial Chemotherapy, vol. 70, no. 8, dkv095, pp. 2397-2404.
'NSAID exacerbated respiratory disease: a meta-analysis evaluating prevalence, mean provocative dose of aspirin and increased asthma morbidity' Allergy, vol. 70, no. 7, pp. 828-835.
'Cognitive behaviour therapy plus aerobic exercise training to increase activity in patients with myotonic dystrophy type 1 (DM1) compared to usual care (OPTIMISTIC): Study protocol for randomised controlled trial' Trials, vol. 16, no. 224, 224.
'The PRECIS-2 tool: designing trials that are fit for purpose' British Medical Journal, vol. 350, h4147.
'The role of perceived barriers and objectively measured physical activity in adults aged 65-100' Age and Ageing, vol. 44, no. 3, pp. 384-390.
'Self-monitoring of blood glucose in type 2 diabetes: Patients' perceptions of "high" readings' Diabetes Technology and Therapeutics, vol. 17, pp. S6.
'A multifaceted intervention to improve sepsis management in general hospital wards with evaluation using segmented regression of interrupted time series' BMJ Quality & Safety, vol. 23, no. 12, e2.
'Risk of AKI with gentamicin as surgical prophylaxis' Journal of the American Society of Nephrology, vol. 25, no. 11, pp. 2625-2632.
'Does a history of depression actually mediate smoking-related pain? findings from a cross-sectional general population-based study' European Journal of Pain, vol. 18, no. 9, pp. 1223-1230.
'Feasibility study of the effects of art as a creative engagement intervention during stroke rehabilitation on improvement of psychosocial outcomes: study protocol for a single blind randomized controlled trial: the ACES study' Trials, vol. 15, 380, pp. 1-12.
'Dog ownership and physical activity in later life: a cross-sectional observational study' Preventive Medicine, vol. 66, pp. 101-106.
'Effect of vitamin D supplementation on orthostatic hypotension: data from the Vitamin D in Isolated Systolic Hypertension randomized controlled trial' Journal of Hypertension, vol. 32, no. 8, pp. 1693-1699.
'Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: meta-analysis of controlled clinical trials' Journal of Allergy and Clinical Immunology, vol. 134, no. 1, pp. 40-45.e10.
'Prediction of liver disease in patients whose liver function tests have been checked in primary care: model development and validation using population-based observational cohorts' BMJ Open, vol. 4, no. 6, e004837.
'A gender-sensitised weight loss and healthy living programme for overweight and obese men delivered by Scottish Premier League football clubs (FFIT): a pragmatic randomised controlled trial' Lancet, vol. 383, no. 9924, pp. 1211-1221.
'Adverse respiratory effect of acute beta-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials' CHEST, vol. 145, no. 4, pp. 779-786.
'Association of day length and weather conditions with physical activity levels in older community dwelling people' PLo S ONE, vol. 9, no. 1, e85331.
'Engages the parts that other therapies cannot reach: experiences of stroke survivors, artists and healthcare staff of an arts based creative engagement intervention in in-patient rehabilitation' International Journal of Stroke : Official Journal of the International Stroke Society, vol. 8, no. 3, pp. 3.
'Surgical interventions for the early management of Bell's palsy' Cochrane Database of Systematic Reviews, vol. 10, CD007468.
'Cholecalciferol Treatment to Reduce Blood Pressure in Older Patients With Isolated Systolic Hypertension: The Vit DISH Randomized Controlled Trial' JAMA Internal Medicine, vol. 173, no. 18, pp. 1672-1679.
'Self-monitoring of blood glucose in type 2 diabetes: patients' perceptions of 'high' readings' Diabetes Research and Clinical Practice, vol. 102, no. 1, pp. e5-e7.
'Goal-setting intervention in patients with active asthma: protocol for a pilot cluster-randomised controlled trial' Trials, vol. 14, 289.
'Psychological theory in an interdisciplinary context: psychological, demographic, health-related, social, and environmental correlates of physical activity in a representative cohort of community-dwelling older adults' International Journal of Behavioral Nutrition and Physical Activity, vol. 10, 106.
'What predicts adverse outcomes in untreated primary hyperparathyroidism? The Parathyroid Epidemiology and Audit Research Study (PEARS)' Clinical Endocrinology, vol. 79, no. 1, pp. 27-34.
'Response to letter commenting on paper EJC-D-12-01401: Use of aspirin post-diagnosis in a cohort of patients with colorectal cancer and its association with all-cause and colorectal cancer specific mortality' European Journal of Cancer, vol. 49, no. 9, pp. 2273.
'Self-monitoring among non-insulin treated patients with type 2 diabetes mellitus: Patients' behavioural responses to readings and associations with glycaemic control' Diabetes Research and Clinical Practice, vol. 100, no. 2, pp. 235-242.
'Prophylactic gentamicin and flucloxacillin is associated with increased rates of acute kidney injury in orthopaedic surgery' Nephrology Dialysis Transplantation, vol. 28, no. supp. 1, MP146, pp. i343-i343.
'Making clinical trials more relevant: improving and validating the PRECIS tool for matching trial design decisions to trial purpose' Trials, vol. 14, 115, pp. 115.
'Cohort study of adherence to adjuvant endocrine therapy, breast cancer recurrence and mortality' British Journal of Cancer, vol. 108, no. 7, pp. 1515-1524.
'Thyroid testing in pregnant women with thyroid dysfunction in Tayside, Scotland: the thyroid epidemiology, audit and research study (TEARS)' Clinical Endocrinology, vol. 78, no. 3, pp. 466-471.
'Use of aspirin post-diagnosis in a cohort of patients with colorectal cancer and its association with all-cause and colorectal cancer specific mortality' European Journal of Cancer, vol. 49, no. 5, pp. 1049-1057.
'Age- and gender-specific TSH reference intervals in people with no obvious thyroid disease in Tayside, Scotland: the thyroid epidemiology, audit, and research study (TEARS)' Journal of Clinical Endocrinology & Metabolism, vol. 98, no. 3, pp. 1147-1153.
'Community-associated Clostridium difficile infection among older people in Tayside, Scotland, is associated with antibiotic exposure and care home residence: cohort study with nested case-control' Journal of Antimicrobial Chemotherapy, vol. 68, no. 12, pp. 2927-2933.
'Impact of clinical trial findings on Bell's palsy management in general practice in the UK 2001–2012: interrupted time series regression analysis ' BMJ Open, vol. 3, no. 7, 003121.
'Prediction of initiation and cessation of breastfeeding from late pregnancy to 16 weeks: the Feeding Your Baby (FYB) cohort study' BMJ Open, vol. 3, no. 8, e003274 .
'The author's reply: nonsustained hypercalcaemia and primary hyperparathyroidism in the PEARS cohort' Clinical Endocrinology.
'Prevalence estimates of diagnosed viral hepatitis B, liver condition outcomes and hospitalization costs: a population record-linkage study in Tayside, Scotland' Epidemiology and Infection, vol. 141, no. 10, pp. 2122-2130.
'The Utility of Liver Function Tests for Mortality Prediction within One Year in Primary Care Using the Algorithm for Liver Function Investigations (ALFI)' PLo S ONE, vol. 7, no. 12, e50965.
'Psychological, health-related, social and environmental predictors of physical activity in the over 65s' Psychology and Health, vol. 27, no. Supplement 1: Resiliance and Health, pp. 121-121.
'A cluster randomised stepped wedge trial to evaluate the effectiveness of a multifaceted information technology-based intervention in reducing high-risk prescribing of non-steroidal anti-inflammatory drugs and antiplatelets in primary medical care: the DQIP study protocol' Implementation Science, pp. 24.
'Patient, practice and organisational influences on asthma control: observational data from a national study on primary care in the United Kingdom' International Journal of Nursing Studies, vol. 49, no. 5, pp. 596-609.
'Social, environmental and psychological factors associated with objective physical activity levels in the over 65s' PLo S ONE, vol. 7, no. 2, e31878, pp. -.
'Evaluating the reliability, validity, acceptability, and practicality of SMS text messaging as a tool to collect research data: results from the Feeding Your Baby project' Journal of the American Medical Informatics Association, vol. 19, no. 5, pp. 744-749.
'Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs' Diabetologia, vol. 55, no. 11, pp. 2929-2937.
'Football Fans in Training (FFIT): a pragmatic randomized controlled trial of a gender-sensitised weight loss and healthy living programme delivered to men aged 35-65 by Scottish Premier League (SPL) football clubs (protocol)' Lancet.
'A record linkage study of outcomes in patients with mild primary hyperparathyroidism: The Parathyroid Epidemiology and Audit Research Study (PEARS)' Clinical Endocrinology, vol. 75, no. 2, pp. 169-176.
'Prescribing of β-adrenoceptor antagonists in asthma: an observational study' Thorax, vol. 66, no. 6, pp. 502-507.
'The natural history of treated and untreated primary hyperparathyroidism: the Parathyroid Epidemiology and Audit Research Study' QJM : an International Journal of Medicine, vol. 104, no. 6, pp. 513-521.
'The Thyroid Epidemiology, Audit, and Research Study (TEARS): morbidity in patients with endogenous subclinical hyperthyroidism' Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 5, pp. 1344-1351.
'Behaviour change plus pedometer in increasing physical activity in sedentary older women' Annals of Behavioral Medicine, vol. 41, no. s1, pp. S132-S132.
'The Thyroid Epidemiology, Audit, and Research Study (TEARS): The Natural History of Endogenous Subclinical Hyperthyroidism' Journal of Clinical Endocrinology & Metabolism, vol. 96, no. 1, pp. E1-E8.
'Integration of e-learning resources into a medical school curriculum' Medical Teacher, vol. 33, no. 4, pp. 311-318.
'Should 'Mild Primary Hyperparathyroidism' be reclassified as 'insidious': is it time to reconsider?' Clinical Endocrinology, vol. 75, no. 6, pp. 730-737.
'Treatment of chronic rhinosinusitis with nasal polyposis with oral steroids followed by topical steroids: a randomized trial' Annals of Internal Medicine, vol. 154, no. 5, pp. 293-302.
'Combined oral and intranasal corticosteroid therapy for nasal polyps' Annals of Internal Medicine, vol. 155, no. 4, pp. 277-278.
'Assessing asthma control in UK primary care: use of routinely collected prospective observational consultation data to determine appropriateness of a variety of control assessment models' BMC Family Practice, vol. 12, 105, pp. -.
'Surgical interventions for the early management of Bell's palsy' Cochrane Database of Systematic Reviews, vol. 2011, no. 2, CD007468, pp. 1-19.
'The development and external validation of a model to predict one year all-cause mortality following liver function tests in primary care patients' Value in Health, vol. 14, no. 7, pp. A392.
'Identifying suspected breast cancer: Development and validation of a clinical prediction rule' British Journal of General Practice, vol. 61, no. 586.