Dr Saville studies the regulation of p53 and its functions in skin cancer.
Alison Sparks, Saurabh Dayal, Joyutpal Das, Pamela Robertson, Sergio Menendez and Mark K. Saville. The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. Oncogene Oct 2013.
Saundh, H; Leigh, IM; South, AP; Saville, MK; Mutant p53 in cutaneous squamous cell carcinoma; Journal of Investigative Dermatology; 2013 May; 133(1)S70-S70.
Koerver, L; Tura, ZH; Leigh, IM; South, AP; Saville, MK; Cutaneous squamous cell carcinoma derived cell lines are more sensitive to the proteasome inhibitor bortezomib than normal skin cells. Journal of Investigative Dermatology; 2013 May; 133(1)S183-S183
Allende-Vega N, Dayal S, Agarwala U, Sparks A, Bourdon JC and Saville MK. p53 is activated in response to disruption of the pre-mRNA splicing machinery. Oncogene: 2013; doi: 10.1038/onc.2012.38. (2013; 32: 1-14).