Li Kang

+44 (0)1382 383019
Discovery Fellow

Bio

Biography

Dr Kang gained her bachelor’s degree in Chemistry from University of Science and Technology of China in 2001 and moved to the US to continue her graduate school at Case Western Reserve University in Cleveland, Ohio. Dr Kang successfully defended her PhD thesis entitled “Chronic ethanol consumption disrupts both lipid and glucose homeostasis in rat adipose tissue” under the supervision of Professor Laura Nagy in 2007.

Dr Kang had her postdoctoral training with Professor David Wasserman at Vanderbilt University and was appointed as a research faculty member of Vanderbilt University Medical Centre in 2012. She was also the Managing Director of the Metabolic Pathophysiology Core of the Vanderbilt Mouse Metabolic Phenotyping Centre between 2012 and 2014.

Dr Kang moved to the UK and joined the faculty of the University of Dundee in April 2014. In this role, Dr Kang is establishing her independent research on understanding the pathogenesis of insulin resistance, focusing on studying the role of extracellular matrix (ECM) remodelling.

Research interests

My research focuses on understanding the pathogenesis of insulin resistance. Emerging evidence suggests that the extracellular matrix (ECM) is of great potential significance in metabolic regulation and possibly is of pivotal significance for all metabolic diseases. By studying mice with specific mutations or mice overexpressing specific genes, my primary research interest centres on understanding the role of ECM remodelling in the pathogenesis of insulin resistance and identifying novel and cost-effective ECM-centric therapeutic targets for insulin resistance and type 2 diabetes. Insulin action in conscious, unstressed mice is studied by the hyperinsulinemic-euglycemic clamp technique. The research that is ongoing in my lab will provide new opportunities to explore therapeutics for insulin resistance and type 2 diabetes.

Teaching

Lecture teaching:

  • Parmacology of Diabetes Treatment
  • BSc Medical Sciences
  • BMSc Cardiovascular and Diabetes

Research projects:

  • PhD/MSc student supervision
  • BSc honour projects
  • BMSc research projects
  • Summer projects

Publications

Cytochrome P450 Epoxygenase-Derived Epoxyeicosatrienoic Acids Contribute to Insulin Sensitivity in Mice and in Humans
2/2017, Diabetologia
Research Output: Contribution To Journal > Article

Adipose extracellular matrix remodelling in obesity and insulin resistance
2/2016, Biochemical Pharmacology
Research Output: Contribution To Journal > Comment/debate

Integrin-linked kinase in muscle is necessary for the development of insulin resistance in diet-induced obese mice
10/2015, Diabetes
Research Output: Contribution To Journal > Article

Mice lacking beta2-integrin function remain glucose tolerant in spite of insulin resistance, neutrophil infiltration and inflammation
1/2015, PLoS ONE
Research Output: Contribution To Journal > Article

The extracellular matrix and insulin resistance
7/2015, Trends in Endocrinology and Metabolism
Research Output: Contribution To Journal > Review article

Enhanced mitochondrial superoxide scavenging does not Improve muscle insulin action in the high fat-fed mouse
5/2015, PLoS ONE
Research Output: Contribution To Journal > Article

Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance
1/2015, Journal of Biological Chemistry
Research Output: Contribution To Journal > Article

Heterozygous SOD2 deletion impairs glucose-stimulated insulin secretion, but not insulin action in high fat-fed mice
6/2014, Diabetes
Research Output: Contribution To Journal > Article

Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity
5/2014, Journal of Clinical Investigation
Research Output: Contribution To Journal > Article

Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice
12/2013, Diabetologia
Research Output: Contribution To Journal > Article

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