Lesley has over 25 years of lab experience doing analysis with Cardiovascular, Respiratory, Diabetic and Aging and Health clinical trial samples. Also samples from external pharmaceutical companies and other science institutes.
Lots of experience with elisa and radioimmunoassays. Measure blood, urine, saliva, sputum and lymphocyte supernatant. Trained in sputum processing.
Certificates in GCP and GCLP.
Lesley has over 35 peer reviewed papers with a selection shown below:
NAIR A, MENZIES D, HOPKINSON P, McFARLANE L, LIPWORTH BJ. In vivo comparison of the relative systemic bioavailability of fluticasone propionate from three anti-static spacers and a metered dose inhaler. Br J Clin Pharmacol 2009;67:191-198
NAIR A, CLEARIE K, MENZIES D, MELDRUM K, McFARLANE L, LIPWORTH BJ. A novel breath-actuated integrated vortex spacer device increases relative lung bioavailability of fluticasone/salmeterol in combination. Pulmonary Pharmacology & Therapeutics 2009: doi:10.1016/j.pupt.2009.02.001
NAIR A, MENZIES D, BARNES M, BURNS P, McFARLANE L, LIPWORTH B. Respirable dose delivery of fluticasone propionate from a small valved holding chamber, a compact breath actuated integrated vortex device and a metered dose inhaler. Br J Clin Pharmacol 2008:66;20-26
MENZIES D, NAIR A, HOPKINSON P, McFARLANE L, LIPWORTH BJ. Differential anti-inflammatory effects of large and small particlae size inhaled corticosteroids in asthma. Allergy 2007;62:661-667
MENZIES D, NAIR A, WILLIAMSON PA, SCHEMBRI S, AL-KHAIRALLA MZH, BARNES M, FARDON TC, McFARLANE L, MAGEE GJ, LIPWORTH BJ. Respiratory Symptoms, Pulmonary Function, and Markers of Inflammation Amongst Bar Workers Before and After a Legislative Ban on Smoking in Public Places. JAMA 2006;296:1742-1748
TAYAB ZR, FARDON TC, LEE DKC, HAGGART K, McFARLANE LC, LIPWORTH BJ, HOCKHAUS G. Pharmacokinetic/pharmacodynamic evaluation of urinary cortisol suppression after inhalation of fluticasone propionate and mometasone furoate. Br J Clin Pharmacol 2007;64:698-705
LEE DKC, FARDON TC, BATES CE, HAGGART K, McFARLANE LC, LIPWORTH BJ. Airway and systemic effects of hydrofluoralkane formulations of high dose ciclesonide and fluticasone in moderate persistent asthma. Chest 2005;127:851-860