Laura Lightfoot

+44 (0)1382 383164
School Manager

Biography

Dr Lightfoot completed her undergraduate degree (BSc Hons) in Anatomical Sciences at the University of Dundee in 1994 before undertaking a PhD funded by the Anatomical Society
investigating gene therapy for dominant and recessive keratin diseases in the School of Life Sciences at Dundee University, which she completed in 1998.

Laura took up an industrial Post-Doctoral Research Manager position in 1998, working in skin biology and moved to Dundee for a postdoctoral position working with Professor Irwin McLean, in the Epithelial Genetics Group, in the Department of Molecular and Cellular Pathology, Faculty of Medicine, Dentistry and Nursing, University of Dundee from 1998 to 2003.

In 2003, Laura took the decision to move from a career in research to one in Higher Education management and commenced in post as the Medical School Assistant Secretary, in the Faculty and then College of Medicine, Dentistry and Nursing, at the University of Dundee where she remained for 7 years, followed by five years at the Dental School in Dundee, as the Dental School Secretary, before returning to the Medical School, as the Medical School Manager, from 2015 as a member of the School Executive Group.

Publications

Sandilands A, Smith FJ, Lunny DP, Campbell LE, Davidson KM, MacCallum SF, Corden LD, Christie L, Fleming S, Lane EB, McLean WH. Generation and characterisation of keratin 7 (K7) knockout mice.. PLoS One. 2013 May 31;8(5):e64404. doi: 0.1371/journal.pone.0064404. Print 2013.

Liao H, Irvine AD, Macewen CJ, Weed KH, Porter L, Corden LD, Gibson AB, Moore JE, Smith FJ, McLean WH, Moore CB. Development of allele-specific therapeutic siRNA in Meesmann epithelial corneal dystrophy. PLoS One. 2011;6(12):e28582. doi: 10.1371/journal.pone.0028582. Epub 2011 Dec 12. 

Skin:  Hereditary Disorders Copyright 2006:  Corden, LD; McLean, WHI; Irvine, A.  Wiley & Sons, Ltd.  ISBN:  0-470-01617-5.

Smith FJ, Porter RM, Corden LD, Lunny DP, Lane EB, McLean WH. Cloning of human, murine, and marsupial keratin 7 and a survey of K7 expression in the mouse. Biochem Biophys Res Commun. 2002 Oct 4;297(4):818-27.

Porter RM, Corden LD, Lunny DP, Smith FJ, Lane EB, McLean WH. Keratin K6irs is specific to the inner root sheath of hair follicles in mice and humans. Br J Dermatol. 2001 Oct;145(4):558-68.

Corden LD, Swensson O, Swensson B, Rochels R, Wannke B, Thiel HJ, McLean WH. A novel keratin 12 mutation in a German kindred with Meesmann's corneal dystrophy. Br J Ophthalmol. 2000 May;84(5):527-30.

Corden LD, Swensson O, Swensson B, Smith FJ, Rochels R, Uitto J, McLEAN WH. Molecular genetics of Meesmann's corneal dystrophy: ancestral and novel mutations in keratin 12 (K12) and complete sequence of the human KRT12 gene. Exp Eye Res. 2000 Jan;70(1):41-9.

Sybert VP, Francis JS, Corden LD, Smith LT, Weaver M, Stephens K, McLean WH. Cyclic ichthyosis with epidermolytic hyperkeratosis: A phenotype conferred by mutations in the 2B domain of keratin K1. Am J Hum Genet. 1999 Mar;64(3):732-8.

Corden LD, Mellerio JE, Gratian MJ, Eady RA, Harper JI, Lacour M, Magee G, Lane EB, McGrath JA, McLean WH. Homozygous nonsense mutation in helix 2 of K14 causes severe recessive epidermolysis bullosa simplex. Hum Mutat. 1998;11(4):279-85.

Smith FJ, Corden LD, Rugg EL, Ratnavel R, Leigh IM, Moss C, Tidman MJ, Hohl D, Huber M, Kunkeler L, Munro CS, Lane EB, McLean WH.  Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex. J Invest Dermatol. 1997 Feb;108(2):220-3.

Corden LD, McLean WH. Human keratin diseases: hereditary fragility of specific epithelial tissues. Exp Dermatol. 1996 Dec;5(6):297-307. Review.

Irvine AD, Corden LD, Swensson O, Swensson B, Moore JE, Frazer DG, Smith FJ, Knowlton RG, Christophers E, Rochels R, Uitto J, McLean WH. Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy. Nat Genet. 1997 Jun;16(2):184-7.

Jonkman MF, Heeres K, Pas HH, van Luyn MJ, Elema JD, Corden LD, Smith FJ, McLean WH, Ramaekers FC, Burton M, Scheffer H. Effects of keratin 14 ablation on the clinical and cellular phenotype in a kindred with recessive epidermolysis bullosa simplex. J Invest Dermatol. 1996 Nov;107(5):764-9.