Jeremy Lambert

+44 (0)1382 383222
Professor of Neuropharmacology

Bio

Biography

Jeremy Lambert obtained his PhD from Strathclyde University, followed by postdoctoral training at the Department of Pharmacology (University of Connecticut, USA) and the Department of Zoology, University of Nottingham. He was appointed to a lectureship in Pharmacology at Dundee University, being made Professor of Neuropharmacology in 1991. Together with Professor David G Nicholls, in 1995 he established the Neuroscience Institute at Dundee University to facilitate the interaction of clinical and scientific neuroscience researchers. With Professor Tim Hales funding was raised to create the Institute of Academic Anaesthesia in 2009. From 1999 - 2011, he was the Head of the Neuroscience Institute. In 1999, he was presented with the Gaddum Memorial Award by the British Pharmacological Society, in 2000 the Gold Medal for “Distinguished Services to Anaesthesia” and in 2002 was the British Pharmacological Society visitor to Australia. He was made a Fellow of the Royal Society of Edinburgh (2004); Fellow of the British Pharmacological Society (2004) and a Fellow of the Royal College of Anaesthetists (2010). He was a co-director of the Wellcome Trust clinical PhD programme at Dundee University.

His main research interests concern synaptic transmission in the central nervous system. See below for current research projects.

Research

The laboratory employs a multidisciplinary approach utilising the techniques of electrophysiology, biochemistry, molecular biology and behaviour. Current research topics include:

The development of novel anxiolytics and pro-cognitive agents.

The GABAA receptor (GABAAR) is an important therapeutic target for drugs such as diazepam. Diazepam binds to a specific site on the GABAAR to enhance the interaction of GABA with the receptor (a positive allosteric modulator – PAM). An important clinical application of diazepam and related benzodiazepines is in the treatment of anxiety. However, the use of such drugs is limited by their side-effect profile, which may include sedation, impaired cognition, tolerance and addiction. The discovery that distinct GABAAR isoforms mediate these various behaviours has encouraged the development of a new generation of GABAAR subtype-selective drugs. In an MRC-funded collaboration, with Professors Atack and Ward (Cardiff University), we are involved in a drug discovery programme to develop novel anxiolytics, which do not cause sedation.

The memory-impairing effects of diazepam appear to be primarily due to the drug acting to enhance the function of the α5-GABAAR subtype. Indeed, α5-GABAAR inhibitors exhibit cognitive enhancing properties. In a Wellcome Trust funded collaboration with Cardiff University, we are involved in the development of novel α5-GABAAR inhibitors to treat the cognitive impairment associated with conditions such as Huntington’s disease (see below). Inhibitors of α5-GABAARs show promise in protecting neurons from damage associated with stroke. In collaboration with Servier (Paris), we discovered S44819, which acts on a site distinct from the benzodiazepine site to selectively inhibit α5-GABAARs. S44819 is currently in clinical trial for treating stroke (Neuropharmacology [2017]; 125: 30-38.)

The molecular mechanism of action of antidepressants.

Depressive disorder is a major psychiatric disease estimated by the World Health Organisation to impair ~ 350 million individuals world-wide. The majority of available antidepressants act to influence the neurotransmitters serotonin and or norepinephrine. However, such treatments require weeks before any benefit is perceived and importantly a substantial proportion of patients show little, or no improvement. Clearly, there is an urgent requirement to evaluate alternative targets for discovering new antidepressant therapeutics. We demonstrated that the clinically used antidepressant tianeptine acts to enhance the function of glutamate-activated AMPA receptors, suggesting an alternative molecular target (Mol. Psychiatry [2013] 18(4): 471-484. In support, the rapid antidepressant actions of ketamine have been shown to be mimicked by a ketamine metabolite that enhances AMPA receptor activity. We are currently investigating the role of AMPARs in the actions of novel antidepressants.

Neurosteroids: endogenous regulators of synaptic inhibition.

Our work and that of others has established that certain neurosteroids (metabolites of progesterone and corticosterone) are endogenous, potent, efficacious, allosteric enhancers of the GABAA receptor function that consequently influence our mood and behaviour  Nat. Neurosci., Rev. [2005]; 6: 565-575). Perturbations of neurosteroid levels are implicated in stress, anxiety, depression and certain forms of epilepsy. Intriguingly ethanol and certain antidepressants such as fluoxetine (Prozac) enhance neurosteroid levels. Our recent studies are revealing that specific brain neurons can synthesise such neurosteroids, which act in an autocrine manner to “fine tune” neuronal inhibition.

How general anaesthetics produce unconsciousness:

It is difficult to conceive of major surgery without the use of a general anaesthetic such as propofol. However, although used clinically for over 160 years, understanding how general anaesthetics produce their dramatic behavioural effects has proved elusive. With Dr. Delia Belelli we demonstrated that the effect of certain anaesthetics to enhance GABAA receptor function was dictated by the nature of a single amino acid on the GABAAR ß2 subunit. In collaboration we demonstrated that a mouse carrying this ß2 subunit mutation became insensitive to the sedative effects of the anaesthetic and that its’ ability to induce unconsciousness was reduced (J. Neurosci., [2003] 23(24); 8608-17; J. Neurosci., [2005] 25(50): 11513-20). These findings raise the prospect of developing novel anaesthetics with reduced sedative (“hangover”) liability. Furthermore, by comparing the activity of anaesthetics on neuronal activity, in brain regions associated with sleep and consciousness (eg. the thalamus) in both normal and “sedative-resistant” models we are beginning to understand how such agents produce their dramatic behavioural effects (J. Physiol., [2008], 586(4): 965-87; Eur. J. Neurosci., [2009] 29(6): 1177-87; J. Neurosci., [2013], 33(9): 3905-14).

Huntington’s disease:

Huntington’s disease (HD) is a fatal, often late onset, neurodegenerative disorder that is inherited in an autosomal dominant manner. Although traditionally classed as causing motor dysfunction, it is now recognised that often, prior to the development of such movement disorders, patients present with psychiatric problems and cognitive dysfunction. In collaboration with Professor Susann Schweiger (Mainz),  and Dr. Rosamund Langston (Dundee), we are using a mouse model of Huntington’s disease to investigate the impact that mutant huntingtin has on synaptic plasticity and behaviour. Our studies reveal that hippocampal long term potentiation (LTP – an electrophysiological correlate of learning and memory) is compromised in such mice and that this malfunction is accompanied by a deficit in their performance of hippocampal-dependent cognitive tasks. The hippocampus is known to exhibit dense expression of the alpha5-GABAA receptor, which we demonstrated to mediate a tonic inhibitory current in hippocampal CA1 pyramidal neurons (Proc. Natl. Acad. Sci. USA [2004] 101(10): 3662-7). In heterozygous HD mice we find an alpha5-GABAA receptor antagonist, enhances LTP and rescues the cognitive deficits, potentially providing a new therapeutic target. In collaboration with Prof Atack (Cardiff) we are involved in a Wellcome Trust drug discovery project to develop novel inhibitors of alpha5-GABAARs to treat this Huntington's disease patients.

The role of GABAA receptors in drug and alcohol addiction:

Collaborators at Sussex University (MRC GABA Cluster; Prof. D Stephens; Dr. S King) demonstrated that the behavioural effects of cocaine are greatly influenced by the presence of the GABAAR alpha2 subunit and studies in Dundee reveal the majority of synaptic inhibition in the medium spiny neurons (MSNs) of the accumbens (a brain region associated with reward and addiction) to be mediated by synaptic alpha2-GABAA receptors (Proc. Natl. Acad. Sci. USA [2010] 107: 2289 - 2294). Intriguingly in humans, haplotypes of the alpha2 subunit are associated with both alcohol and drug eg cocaine addiction. This association is particularly evident for individuals with a history of early life stress or trauma. In collaboration with Dr Delia Belelli (Dundee), Prof. D Stephens & Dr. S King (Sussex University) and Dr. J Swinny (Portsmouth University), we are investigating the link between the alpha2 subunit, neuronal function, addiction and childhood trauma. Accumbal MSNs additionally express extrasynaptic GABAARs composed of alpha4, beta and delta subunits, which mediate a tonic, persistent form of inhibition that greatly influences neuronal excitability (J. Neurosci., [2014] 34(3): 823-38). Deletion of the alpha 4 or delta subunit from the accumbens reduces alcohol intake. Importantly, in collaboration with colleagues at Imperial College, University College London, Sussex University and Newcastle University we have uncovered an important role for the GABAAR beta1 subunit in alcohol behaviour (Nat. Commun. [2013], 4: 2816). Two mouse lines were discovered carrying distinct point mutations of the beta1 subunit (Figure 2). In common, both of these mutations resulted in a much increased tonic conductance in the accumbens. Furthermore, mice from both lines showed a greater preference and desire for ethanol over water. These findings demonstrate that excessive drinking can be caused by a single mutation and suggest that these accumbal extrasynaptic receptors as a novel target for treating addiction. In related studies we have identified extrasynaptic glycine receptors as an additional sensitive target for ethanol (Neuropsychopharm, [2013], 33(50): 19534-54).

 

Teaching

2nd Year Undergraduate Biomedical Sciences (BS22001) Synaptic transmission.

2nd Year Undergraduate Biomedical Sciences (BS22003) Laboratory & Research Skills.

3rd Year  Biomembranes (BS 31013) Transmitter-gated ion channel physiology & pharmacology.

3rd Year Undergraduate - Neuropsychopharmacology (BS32024)

Year 4 - Undergraduate Neuroscience, Pharmacology & BIMS students. (BS42025). The conscious brain: The physiology & pharmcology of pain & anaesthesia.

Year 4- Undergraduate Neuroscience, Pharmacology & BIMs students. (BS42017) Psychiatric disorders.

Medical BMSc students. BM40024. Analgesic & anaesthetic Pharmacology

Medical BMSc students. BM40026. Psychiatric disorders.

 

Postgraduate supervision currently of 3 PhD students.

Publications

Mitchell, SJ, Maguire, EP, Cunningham, L, Gunn, BG, Linke, M, Zechner, U, Dixon, CI, King, SL, Stephens, DN, Swinny, JD, Belelli, D & Lambert, JJ 2018,

'Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine' Neuropharmacology, vol. 141, pp. 98-112.
https://doi.org/10.1016/j.neuropharm.2018.08.021

Research output: Contribution To Journal



Arnoux, I, Willam, M, Griesche, N, Krummeich, J, Watari, H, Offermann, N, Weber, S, Narayan Dey, P, Chen, C, Monteiro, O, Buettner, S, Meyer, K, Bano, D, Radyushkin, K, Langston, R, Lambert, JJ, Wanker, E, Methner, A, Krauss, S, Schweiger, S & Stroh, A 2018,

'Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease' e Life, vol. 7, e38744.
https://doi.org/10.7554/e Life.38744

Research output: Contribution To Journal



Monteiro, O, Chen, C, Bingham, R, Argyrou, A, Buxton, R, Jönsson, CP, Jones, E, Bridges, A, Gatfield, K, Krauß, S, Lambert, J, Langston, R, Schweiger, S & Uings, I 2018,

'Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures' Neuroscience Letters, vol. 673, pp. 44-50.
https://doi.org/10.1016/j.neulet.2018.02.061

Research output: Contribution To Journal



Sharp, S, Mitchell, S, Vallée, M, Kuzmanova, E, Cooper, M, Belelli, D, Lambert, J & Huang, J 2018,

'An isotope dilution based-targeted and non-targeted carbonyl neurosteroid/steroid profiling' Analytical Chemistry, vol. 90, no. 8, pp. 5247-5255.
https://doi.org/10.1021/acs.analchem.8b00055

Research output: Contribution To Journal



Belelli, D, Brown, AR, Mitchell, SJ, Gunn, BG, Herd, MB, Phillips, GD, Seifi, M, Swinny, JD & Lambert, JJ 2018,

'Endogenous neurosteroids influence synaptic GABAA receptors during post-natal development' Journal of Neuroendocrinology, vol. 30, no. 2, e12537, pp. 11-15.
https://doi.org/10.1111/jne.12537

Research output: Contribution To Journal



Bull, FA, Baptista-Hon, DT, Lambert, JJ, Walwyn, W & Hales, TG 2017,

'Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src' Scientific Reports, vol. 7, no. 1, 9969, pp. 1-11.
https://doi.org/10.1038/s41598-017-10360-8

Research output: Contribution To Journal



Weir, CJ, Mitchell, SJ & Lambert, JJ 2017,

'Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics' British Journal of Anaesthesia, vol. 119, no. Suppl. 1, pp. i167-i175.
https://doi.org/10.1093/bja/aex369

Research output: Contribution To Journal



Gacsályi, I, Móricz, K, Gigler, G, Wellmann, J, Nagy, K, Ling, I, Barkóczy, J, Haller, J, Lambert, JJ, Szénási, G, Spedding, M & Antoni, FA 2017,

'Behavioural pharmacology of the α5-GABAA receptor antagonist S44819: Enhancement and remediation of cognitive performance in preclinical models' Neuropharmacology, vol. 125, pp. 30-38.
https://doi.org/10.1016/j.neuropharm.2017.07.005

Research output: Contribution To Journal



Etherington, L-A, Mihalik, B, Pálvölgyi, A, Ling, I, Pallagi, K, Kertész, S, Varga, P, Gunn, BG, Brown, AR, Livesey, MR, Monteiro, O, Belelli, D, Barkóczy, J, Spedding, M, Gacsályi, I, Antoni, FA & Lambert, JJ 2017,

'Selective inhibition of extra-synaptic α5-GABAA receptors by S44819, a new therapeutic agent' Neuropharmacology, vol. 125, pp. 353-364.
https://doi.org/10.1016/j.neuropharm.2017.08.012

Research output: Contribution To Journal



Kumar, N, Fagart, J, Liere, P, Mitchell, SJ, Knibb, AR, Petit-Topin, I, Rame, M, El-Etr, M, Schumacher, M, Lambert, JJ, Rafestin-Oblin, M-E & Sitruk-Ware, R 2017,

'Nestorone® as a Novel Progestin for Nonoral Contraception: Structure-Activity Relationships and Brain Metabolism Studies ' Endocrinology, vol. 158, no. 1, pp. 170-182.
https://doi.org/10.1210/en.2016-1426

Research output: Contribution To Journal



Stephens, DN, King, SL, Lambert, JJ, Belelli, D & Duka, T 2017,

'GABAA receptor subtype involvement in addictive behaviour' Genes, Brain and Behavior, vol. 16, no. 1, pp. 149-184.
https://doi.org/10.1111/gbb.12321

Research output: Contribution To Journal



Brown, AR, Mitchell, S, Peden, DR, Herd, MB, Seifi, M, Swinny, JD, Belelli, D & Lambert, J 2016,

'During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons' Neuropharmacology, vol. 103, pp. 163-173.
https://doi.org/10.1016/j.neuropharm.2015.11.019

Research output: Contribution To Journal



Ling, I, Mihalik, B, Etherington, L-A, Kapus, G, Pálvölgyi, A, Gigler, G, Kertész, S, Gaál, A, Pallagi, K, Kiricsi, P, Szabó, É, Szénási, G, Papp, L, Hársing, LG, Lévay, G, Spedding, M, Lambert, JJ, Belelli, D, Barkóczy, J, Volk, B, Simig, G, Gacsályi, I & Antoni, FA 2015,

'A novel GABAA alpha 5 receptor inhibitor with therapeutic potential' European Journal of Pharmacology, vol. 764, pp. 497-507.
https://doi.org/10.1016/j.ejphar.2015.07.005

Research output: Contribution To Journal



Golovko, T, Min, R, Lozovaya, N, Falconer, C, Yatsenko, N, Tsintsadze, T, Tsintsadze, V, Ledent, C, Harvey, RJ, Belelli, D, Lambert, JJ, Rozov, A & Burnashev, N 2015,

'Control of inhibition by the direct action of cannabinoids on GABAA receptors' Cerebral Cortex, vol. 25, no. 9, pp. 2440-2455.
https://doi.org/10.1093/cercor/bhu045

Research output: Contribution To Journal



Corteen, NL, Carter, JA, Rudolph, U, Belelli, D, Lambert, JJ & Swinny, JD 2015,

'Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus' Brain Structure and Function, vol. 220, no. 5, pp. 2739-2763.
https://doi.org/10.1007/s00429-014-0824-7

Research output: Contribution To Journal



Brown, AR, Herd, MB, Belelli, D & Lambert, JJ 2015,

'Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones' Journal of Physiology, vol. 593, no. 1, pp. 267-284.
https://doi.org/10.1113/jphysiol.2014.280263

Research output: Contribution To Journal



Gunn, BG, Cunningham, L, Mitchell, SG, Swinny, JD, Lambert, JJ & Belelli, D 2015,

'GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response' Frontiers in Neuroendocrinology, vol. 36, pp. 28-48.
https://doi.org/10.1016/j.yfrne.2014.06.001

Research output: Contribution To Journal



Herd, MB, Lambert, JJ & Belelli, D 2014,

'The general anaesthetic etomidate inhibits the excitability of mouse thalamocortical relay neurons by modulating multiple modes of GABAA receptor-mediated inhibition' European Journal of Neuroscience, vol. 40, no. 3, pp. 2487-501.
https://doi.org/10.1111/ejn.12601

Research output: Contribution To Journal



Maguire, EP, Mitchell, EA, Greig, SJ, Corteen, N, Balfour, DJK, Swinny, JD, Lambert, JJ & Belelli, D 2014,

'Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons: a sensitive target for ethanol' Neuropsychopharmacology, vol. 39, no. 5, pp. 1232-1244.
https://doi.org/10.1038/npp.2013.326

Research output: Contribution To Journal



Maguire, EP, Macpherson, T, Swinny, JD, Dixon, CI, Herd, MB, Belelli, D, Stephens, DN, King, SL & Lambert, JJ 2014,

'Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants' Journal of Neuroscience, vol. 34, no. 3, pp. 823-838.
https://doi.org/10.1523/JNEUROSCI.3232-13.2014

Research output: Contribution To Journal



Seifi, M, Brown, JF, Mills, J, Bhandari, P, Belelli, D, Lambert, JJ, Rudolph, U & Swinny, JD 2014,

'Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon' Journal of Neuroscience, vol. 34, no. 31, pp. 10361-10378.
https://doi.org/10.1523/JNEUROSCI.0441-14.2014

Research output: Contribution To Journal



Gunn, B, Cunningham, L, Cooper, MA, Corteen, N, Seifi, M, Swinny, JD, Lambert, JJ & Belelli, D 2013,

'Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress-response.' Journal of Neuroscience, vol. 33, no. 50, pp. 19534-19554.
https://doi.org/10.1523/JNEUROSCI.1337-13.2013

Research output: Contribution To Journal



Anstee, Q, Knapp, S, Maguire, EP, Hosie, AM, Thomas, P, Mortensen, M, Bhome, R, Martinez, A, Walker, SE, Dixon, CI, Ruparelia, K, Montagnese, S, Kuo, Y-T, Herlihy, A, Bell, JD, Robinson, I, Guerrini, I, Mc Quillin, A, Fisher, EMC, Ungless, MA, Gurling, HMD, Morgan, MY, Brown, SDM, Stephens, DN, Belelli, D, Lambert, J, Smart, TG & Thomas, HC 2013,

'Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition' Nature Communications, vol. 4, 2816.
https://doi.org/10.1038/ncomms3816

Research output: Contribution To Journal



Carland, JE, Cooper, MA, Livesey, MR, Hales, TG, Lambert, JJ & Peters, JA 2013,

'Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor' Journal of Biological Chemistry, vol. 288, no. 44, pp. 31592-31601.
https://doi.org/10.1074/jbc.M113.503300

Research output: Contribution To Journal



Herd, M, Brown, AR, Lambert, J & Belelli, D 2013,

'Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus' Journal of Neuroscience, vol. 33, no. 37, pp. 14850-14868.
https://doi.org/10.1523/JNEUROSCI.1174-13.2013

Research output: Contribution To Journal



Baptista-Hon, DT, Deeb, TZ, Lambert, JJ, Peters, JA & Hales, TG 2013,

'The minimum M3-M4 loop length of neurotransmitteractivated pentameric receptors is critical for the structural integrity of cytoplasmic portals' Journal of Biological Chemistry, vol. 288, no. 30, pp. 21558-21568.
https://doi.org/10.1074/jbc.M113.481689

Research output: Contribution To Journal



Wlodarczyk, AI, Sylantyev, S, Herd, MB, Kersanté, F, Lambert, JJ, Rusakov, DA, Linthorst, ACE, Semyanov, A, Belelli, D, Pavlov, I & Walker, MC 2013,

'GABA-Independent GABAA Receptor Openings Maintain Tonic Currents' Journal of Neuroscience, vol. 33, no. 9, pp. 3905-3914.
https://doi.org/10.1523/JNEUROSCI.4193-12.2013

Research output: Contribution To Journal



Jensen, ML, Wafford, KA, Brown, AR, Belelli, D, Lambert, JJ & Mirza, NR 2013,

'A study of subunit selectivity, mechanism and site of action of the delta selective compound 2 (DS2) at human recombinant and rodent native GABAA receptors' British Journal of Pharmacology, vol. 168, no. 5, pp. 1118-1132.
https://doi.org/10.1111/bph.12001

Research output: Contribution To Journal



Newman, AS, Batis, N, Grafton, G, Caputo, F, Brady, CA, Lambert, JJ, Peters, JA, Gordon, J, Barnes, NM, Brain, KL, Powell, AD & Barnes, NM 2013,

'5-chloroindole: a potent allosteric modulator of the 5-HT3 receptor' British Journal of Pharmacology, vol. 169, no. 6, pp. 1228-1238.
https://doi.org/10.1111/bph.12213

Research output: Contribution To Journal



Peters, J, Cooper, M, Livesey, M, Carland, J & Lambert, J 2012,

5-HT3 receptors. in J Kew & C Davies (eds), Ion Channels: From Structure to Function. Oxford University Press, Oxford, pp. 232-251.
https://doi.org/10.1093/acprof:oso/9780199296750.003.0007

Research output: Contribution To Book Anthology



Zhang, H, Etherington, L-A, Hafner, A-S, Belelli, D, Coussen, F, Delagrange, P, Chaouloff, F, Spedding, M, Lambert, JJ, Choquet, D & Groc, L 2012,

'Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule' Molecular psychiatry, vol. 18, pp. 471-484.
https://doi.org/10.1038/mp.2012.80

Research output: Contribution To Journal



Gunn, BG, Brown, AR, Lambert, JJ & Belelli, D 2011,

'Neurosteroids and GABAA receptor interactions: A focus on stress' Frontiers in Neuroscience, vol. 5, 131, pp. 1-20.
https://doi.org/10.3389/fnins.2011.00131

Research output: Contribution To Journal



Panzanelli, P, Gunn, BG, Schlatter, MC, Benke, D, Tyagarajan, SK, Scheiffele, P, Belelli, D, Lambert, JJ, Rudolph, U & Fritschy, J-M 2011,

'Distinct mechanisms regulate GABA(A) receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells' Journal of Physiology, vol. 589, no. 20, pp. 4959-4980.
https://doi.org/10.1113/jphysiol.2011.216028

Research output: Contribution To Journal



Livesey, MR, Cooper, MA, Lambert, JJ & Peters, JA 2011,

'Rings of Charge within the Extracellular Vestibule Influence Ion Permeation of the 5-HT(3)A Receptor' Journal of Biological Chemistry, vol. 286, no. 18, pp. 16008-16017.
https://doi.org/10.1074/jbc.M111.219618

Research output: Contribution To Journal



Belelli, D, Gunn, BG, Maguire, EP & Lambert, JJ 2011,

'The actions of neurosteroids at alpha 2-GABAA receptors in stress-sensitive neuronal targets' Alcohol, vol. 45, no. 3, S85, pp. 287-287.
https://doi.org/10.1016/j.alcohol.2011.02.142

Research output: Contribution To Journal



Peters, JA, Cooper, MA, Carland, JE, Livesey, MR, Hales, TG & Lambert, JJ 2010,

'Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors' Journal of Physiology, vol. 588, no. 4, pp. 587-595.
https://doi.org/10.1113/jphysiol.2009.183137

Research output: Contribution To Journal



Dixon, CI, Morris, HV, Breen, G, Desrivieres, S, Jugurnauth, S, Steiner, RC, Vallada, H, Guindalini, C, Laranjeira, R, Messas, G, Rosahl, TW, Atack, JR, Peden, DR, Belelli, D, Lambert, JJ, King, SL, Schumann, G & Stephens, DN 2010,

'Cocaine effects on mouse incentive-learning and human addiction are linked to alpha 2 subunit-containing GABA(A) receptors' Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 5, pp. 2289-2294.
https://doi.org/10.1073/pnas.0910117107

Research output: Contribution To Journal



Lambert, JJ, Cooper, MA, Simmons, RDJ, Weir, CJ & Belelli, D 2009,

'Neurosteroids: Endogenous allosteric modulators of GABA receptors' Psychoneuroendocrinology, vol. 34, no. SUPPL. 1.
https://doi.org/10.1016/j.psyneuen.2009.08.009

Research output: Contribution To Journal



Stephens, DN, Belelli, D, Lambert, JJ, Thomas, H & King, SL 2009,

'Gaba(A) receptor subunits: their contribution to ethanol and other addictive behaviours in mice' Alcoholism: Clinical and Experimental Research, vol. 33, no. S1, 112, pp. 294A-294A.
https://doi.org/10.1111/j.1530-0277.2009.00948.x

Research output: Contribution To Journal



Herd, MB, Foister, N, Chandra, D, Peden, DR, Homanics, GE, Brown, VJ, Balfour, DJK, Lambert, JJ & Belelli, D 2009,

'Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors' European Journal of Neuroscience, vol. 29, no. 6, pp. 1177-1187.
https://doi.org/10.1111/j.1460-9568.2009.06680.x

Research output: Contribution To Journal



Carland, JE, Cooper, MA, Sugiharto, S, Jeong, H-J, Lewis, TM, Barry, PH, Peters, JA, Lambert, JJ & Moorhouse, AJ 2009,

'Characterization of the Effects of Charged Residues in the Intracellular Loop on Ion Permeation in alpha 1 Glycine Receptor Channels' Journal of Biological Chemistry, vol. 284, no. 4, pp. 2023-2030.
https://doi.org/10.1074/jbc.M806618200

Research output: Contribution To Journal



Wafford, KA, van Niel, MB, Ma, QP, Horridge, E, Herd, MB, Peden, DR, Belelli, D & Lambert, J 2009,

'Novel compounds selectively enhance delta subunit containing GABA(A) receptors and increase tonic currents in thalamus' Neuropharmacology, vol. 56, no. 1, pp. 182-189.
https://doi.org/10.1016/j.neuropharm.2008.08.004

Research output: Contribution To Journal



Solovyova, N, Moult, PR, Milojkovic, B, Lambert, JJ & Harvey, J 2009,

'Bi-directional modulation of fast inhibitory synaptic transmission by leptin' Journal of Neurochemistry, vol. 108, no. 1, pp. 190-201.
https://doi.org/10.1111/j.1471-4159.2008.05751.x

Research output: Contribution To Journal



Moorhouse, A, Carland, JE, Cooper, MA, Sugiharto, S, Jeong, H-J, Lewis, TM, Barry, PH, Peters, JA & Lambert, JJ 2009,

'Molecular determinants of ion permeation in glycine receptor-channels: characterising charged residues in the intracellular m3-m4 loop' Journal of Physiological Sciences, vol. 59, no. S1, pp. 393-393.

Research output: Contribution To Journal



Ahrens, J, Leuwer, M, Stachura, S, Krampfl, K, Belelli, D, Lambert, JJ & Haeseler, G 2008,

'A Transmembrane Residue Influences the Interaction of Propofol with the Strychnine-Sensitive Glycine alpha(1) and alpha(1)beta Receptor' Anesthesia and Analgesia, vol. 107, no. 6, pp. 1875-1883.
https://doi.org/10.1213/ane.0b013e3181875a31

Research output: Contribution To Journal



Simmons, DR, Gillespie, J, Cooper, MA, Weir, CJ, Belelli, D & Lambert, JJ 2008,

'Stereoselective interaction of neurosteroids with strychnine-sensitive glycine receptors' British Journal of Anaesthesia, vol. 101, no. 4, pp. 592P-593P.
https://doi.org/10.1093/bja/aen238

Research output: Contribution To Journal



Livesey, MR, Cooper, MA, Deeb, TZ, Carland, JE, Kozuska, J, Hales, TG, Lambert, JJ & Peters, JA 2008,

'Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor' Journal of Biological Chemistry, vol. 283, no. 28, pp. 19301-19313.
https://doi.org/10.1074/jbc.M802406200

Research output: Contribution To Journal



Simmons, DR, Gillespie, J, Weir, CJ, Belelli, D, Lambert, JJ & Cooper, M 2008,

'A transmembrane amino acid determines neurosteroid modulation of strychnine-sensitive glycine receptors' British Journal of Anaesthesia, vol. 100, no. 4, pp. 581P-581P.
https://doi.org/10.1093/bja/aem397

Research output: Contribution To Journal



Peden, DR, Petitjean, CM, Herd, MB, Durakoglugil, MS, Rosahl, TW, Wafford, K, Homanics, GE, Belelli, D, Fritschy, J-M & Lambert, JJ 2008,

'Developmental maturation of synaptic and extrasynaptic GABA(A) receptors in mouse thalamic ventrobasal neurones' Journal of Physiology, vol. 586, no. 4, pp. 965-987.
https://doi.org/10.1113/jphysiol.2007.145375

Research output: Contribution To Journal



Herd, MB, Haythornthwaite, AR, Rosahl, TW, Wafford, KA, Homanics, GE, Lambert, JJ & Belelli, D 2008,

'The expression of GABA(A) beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells' Journal of Physiology, vol. 586, no. 4, pp. 989-1004.
https://doi.org/10.1113/jphysiol.2007.146746

Research output: Contribution To Journal



Lambert, J, Gunn, B, Brown, A, Mitchell, E, Simmons, R, Herd, MB & Belelli, D 2008,

'Neurosteroids: endogenous modulators of GABA-A receptor' European Neuropsychopharmacology, vol. 18, no. S4, S.24.01, pp. S190-S191.
https://doi.org/10.1016/S0924-977X(08)70206-2

Research output: Contribution To Journal



Mitchell, EA, Herd, MB, Gunn, BG, Lambert, JJ & Belelli, D 2008,

'Neurosteroid modulation of GABA(A) receptors: Molecular determinants and significance in health and disease' Neurochemistry International, vol. 52, no. 4-5, pp. 588-595.
https://doi.org/10.1016/j.neuint.2007.10.007

Research output: Contribution To Journal



Deniau, G, Slawin, AMZ, Lebl, T, Chorki, F, Issberner, JP, van Mourik, T, Heygate, JM, Lambert, JJ, Etherington, L-A, Sillar, KT & O'Hagan, D 2007,

'Synthesis, conformation and biological evaluation of the enantiomers of 3-fluoro-gamma-aminobutyric acid ((R)- and (S)-3F-GABA): An analogue of the neurotransmitter GABA' Chem Bio Chem, vol. 8, no. 18, pp. 2265-2274.
https://doi.org/10.1002/cbic.200700371

Research output: Contribution To Journal



Herd, MB, Belelli, D & Lambert, JJ 2007,

'Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors' Pharmacology & Therapeutics, vol. 116, no. 1, pp. 20-34.
https://doi.org/10.1016/j.pharmthera.2007.03.007

Research output: Contribution To Journal



Deeb, TZ, Carland, JE, Cooper, MA, Livesey, MR, Lambert, JJ, Peters, JA & Hales, TG 2007,

'Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor' Journal of Biological Chemistry, vol. 282, no. 9, pp. 6172-6182.
https://doi.org/10.1074/jbc.M607698200

Research output: Contribution To Journal



Agid, Y, Buzsáki, G, Diamond, DM, Frackowiak, R, Giedd, J, Girault, J-A, Grace, A, Lambert, JJ, Manji, H, Mayberg, H, Popoli, M, Prochiantz, A, Richter-Levin, G, Somogyi, P, Spedding, M, Svenningsson, P & Weinberger, D 2007,

'How can drug discovery for psychiatric disorders be improved?' Nature Reviews Drug Discovery, vol. 6, no. 3, pp. 189-201.
https://doi.org/10.1038/nrd2217

Research output: Contribution To Journal



Peters, JA, Carland, JE, Cooper, MA, Livesey, MR, Deeb, TZ, Hales, TG & Lambert, JJ 2006,

'Novel structural determinants of the single-channel conductance in nicotinic acetylcholine and 5-hydroxytryptamine type-3 receptors' Biochemical Society Transactions, vol. 34, no. 5, pp. 882-886.
https://doi.org/10.1042/BST0340882

Research output: Contribution To Journal



Belelli, D, Herd, MB, Mitchell, EA, Peden, DR, Vardy, AW, Gentet, L & Lambert, JJ 2006,

'Neuroactive steroids and inhibitory neurotransmission: Mechanisms of action and physiological relevance' Neuroscience, vol. 138, no. 3, pp. 821-829.
https://doi.org/10.1016/j.neuroscience.2005.07.021

Research output: Contribution To Journal



Hales, TG, Dunlop, JI, Deeb, TZ, Carland, JE, Kelley, SP, Lambert, JJ & Peters, JA 2006,

'Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and α4β2 nicotinic acetylcholine receptors' Journal of Biological Chemistry, vol. 281, no. 12, pp. 8062-8071.
https://doi.org/10.1074/jbc.M513222200

Research output: Contribution To Journal



Borghese, CM, Storustovu, SI, Ebert, B, Herd, MB, Belelli, D, Lambert, JJ, Marshall, G, Wafford, KA & Harris, RA 2006,

'The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol' Journal of Pharmacology and Experimental Therapeutics, vol. 316, no. 3, pp. 1360-1368.
https://doi.org/10.1124/jpet.105.092452

Research output: Contribution To Journal



Magnaghi, V, Ballabio, M, Consoli, A, Lambert, JJ, Roglio, I & Melcangi, RC 2006,

'GABA receptor-mediated effects in the peripheral nervous system: A cross-interaction with neuroactive steroids' Journal of Molecular Neuroscience, vol. 28, no. 1, pp. 89-102.
https://doi.org/10.1385/JMN:28:1:89

Research output: Contribution To Journal



Eisensamer, B, Uhr, M, Meyr, S, Gimpl, G, Deiml, T, Rammes, G, Lambert, JJ, Zieglgänsberger, W, Holsboer, F & Rupprecht, R 2005,

'Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains' Journal of Neuroscience, vol. 25, no. 44, pp. 10198-10206.
https://doi.org/10.1523/JNEUROSCI.2460-05.2005

Research output: Contribution To Journal



Peters, JA, Hales, TG & Lambert, JJ 2005,

'Molecular determinants of single-channel conductance and ion selectivity in the Cys-loop family: insights from the 5-HT3 receptor' Trends in Pharmacological Sciences, vol. 26, no. 11, pp. 587-94.
https://doi.org/10.1016/j.tips.2005.09.011

Research output: Contribution To Journal



Lambert, JJ, Haythornthwaite, AR, Peden, DR, Herd, MB, Wafford, KA, Rosahl, TW & Belelli, D 2005,

'The GABAA receptor: An important target for the general anaesthetic etomidate' International Congress Series, vol. 1283, pp. 67-72.
https://doi.org/10.1016/j.ics.2005.07.071

Research output: Contribution To Journal



Belelli, D & Lambert, JJ 2005,

'Neurosteroids: Endogenous regulators of the GABAA receptor' Nature Reviews Neuroscience, vol. 6, no. 7, pp. 565-575.
https://doi.org/10.1038/nrn1703

Research output: Contribution To Journal



Belelli, D, Peden, DR, Rosahl, TW, Wafford, KA & Lambert, JJ 2005,

'Extrasynaptic GABA(A) receptors of thalamocortical neurons: a molecular target for hypnotics' Journal of Neuroscience, vol. 25, no. 50, pp. 11513-11520.
https://doi.org/10.1523/JNEUROSCI.2679-05.2005

Research output: Contribution To Journal



Peters, JA, Kelley, SP, Dunlop, JI, Kirkness, EF, Hales, TG & Lambert, JJ 2004,

'The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance' Biochemical Society Transactions, vol. 32, no. 3, pp. 547-552.
https://doi.org/10.1042/BST0320547

Research output: Contribution To Journal



Magnaghi, V, Ballabio, M, Cavarretta, ITR, Froestl, W, Lambert, JJ, Zucchi, I & Melcangi, RC 2004,

'GABAB receptors in Schwann cells influence proliferation and myelin protein expression' European Journal of Neuroscience, vol. 19, no. 10, pp. 2641-2649.
https://doi.org/10.1111/j.0953-816X.2004.03368.x

Research output: Contribution To Journal



Weir, CJ, Ling, ATY, Belelli, D, Wildsmith, JAW, Peters, JA & Lambert, JJ 2004,

'The interaction of anaesthetic steroids with recombinant glycine and GABAA receptors' British journal of anaesthesia, vol. 92, no. 5, pp. 704-711.
https://doi.org/10.1093/bja/aeh425

Research output: Contribution To Journal



Caraiscos, VB, Elliott, EM, You-Ten, KE, Cheng, VY, Belelli, D, Newell, JG, Jackson, MF, Lambert, JJ, Rosahl, TW, Wafford, KA, Mac Donald, JF, Orser, BA & Iversen, LL (ed.) 2004,

'Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors' Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 10, pp. 3662-3667.
https://doi.org/10.1073/pnas.0307231101

Research output: Contribution To Journal



Spruce, BA, Campbell, LA, Mc Tavish, N, Cooper, MA, Appleyard, MVL, O'Neill, M, Howie, J, Samson, J, Watt, S, Murray, K, Mc Lean, D, Leslie, NR, Safrany, ST, Ferguson, MJ, Peters, JA, Prescott, AR, Box, G, Hayes, A, Nutley, B, Raynaud, F, Downes, CP, Lambert, JJ, Thompson, AM & Eccles, S 2004,

'Small molecule antagonists of the σ-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo' Cancer Research, vol. 64, no. 1, pp. 4875-4886.
https://doi.org/10.1158/0008-5472.CAN-03-3180

Research output: Contribution To Journal



Pau, D, Belelli, D, Callachan, H, Peden, DR, Dunlop, JI, Peters, JA, Guitart, X, Gutierrez, B & Lambert, JJ 2003,

'GABAA receptor modulation by the novel intravenous general anaesthetic E-6375' Neuropharmacology, vol. 45, no. 8, pp. 1029-1040.
https://doi.org/10.1016/S0028-3908(03)00299-5

Research output: Contribution To Journal



Harney, SC, Frenguelli, BG & Lambert, JJ 2003,

'Phosphorylation influences neurosteroid modulation of synaptic GABA A receptors in rat CA1 and dentate gyrus neurones' Neuropharmacology, vol. 45, no. 6, pp. 873-883.
https://doi.org/10.1016/S0028-3908(03)00251-X

Research output: Contribution To Journal



Reynolds, DS, Rosahl, TW, Cirone, J, O'Meara, GF, Haythornthwaite, A, Newman, RJ, Myers, J, Sur, C, Howell, O, Rutter, AR, Atack, J, Macaulay, AJ, Hadingham, KL, Hutson, PH, Belelli, D, Lambert, J, Dawson, GR, Mc Kernan, R, Whiting, PJ & Wafford, KA 2003,

'Sedation and anesthesia mediated by distinct GABAA receptor isoforms' Journal of Neuroscience, vol. 23, no. 24, pp. 8608-8617.

Research output: Contribution To Journal



Lambert, JJ, Belelli, D, Peden, DR, Vardy, AW & Peters, JA 2003,

'Neurosteroid modulation of GABAA receptors' Progress in neurobiology, vol. 71, no. 1, pp. 67-80.
https://doi.org/10.1016/j.pneurobio.2003.09.001

Research output: Contribution To Journal



Schumacher, M, Weill-Engerer, S, Liere, P, Robert, F, Franklin, RJM, Garcia-Segura, LM, Lambert, JJ, Mayo, W, Melcangi, RC, Parducz, A, Suter, U, Carelli, C, Baulieu, EE & Akwa, Y 2003,

'Steroid hormones and neurosteroids in normal and pathological aging of the nervous system' Progress in neurobiology, vol. 71, no. 1, pp. 3-29.
https://doi.org/10.1016/j.pneurobio.2003.09.004

Research output: Contribution To Journal



Kelley, SP, Dunlop, JI, Kirkness, EF, Lambert, JJ & Peters, JA 2003,

'A cytoplasmic region determines single-channel conductance in 5-HT3 receptors' Nature, vol. 424, no. 6946, pp. 321-324.
https://doi.org/10.1038/nature01788

Research output: Contribution To Journal



Belelli, D, Muntoni, A-L, Merrywest, SD, Gentet, LJ, Casula, A, Callachan, H, Madau, P, Gemmell, DK, Hamilton, NM, Lambert, JJ, Sillar, KT & Peters, JA 2003,

'The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia' Neuropharmacology, vol. 45, no. 1, pp. 57-71.
https://doi.org/10.1016/S0028-3908(03)00144-8

Research output: Contribution To Journal



Belelli, D, Casula, A, Ling, A & Lambert, JJ 2002,

'The influence of subunit composition on the interaction of neurosteroids with GABAA receptors' Neuropharmacology, vol. 43, no. 4, pp. 651-661.
https://doi.org/10.1016/S0028-3908(02)00172-7

Research output: Contribution To Journal



Lambert, JJ & Belelli, D 2002,

'Pharmacological characterization of a novel cell line expressing human α 4β 3δ GABA A receptors: Commentary on Brown et al' British Journal of Pharmacology, vol. 136, no. 7, pp. 957-959.
https://doi.org/10.1038/sj.bjp.0704796

Research output: Contribution To Journal



Boyd, GW, Low, P, Dunlop, JI, Robertson, LA, Vardy, A, Lambert, JJ, Peters, JA & Connolly, CN 2002,

'Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins' Molecular and Cellular Neuroscience, vol. 21, no. 1, pp. 38-50.
https://doi.org/10.1006/mcne.2002.1160

Research output: Contribution To Journal



Lambert, JJ, Belelli, D, Harney, SC, Peters, JA & Frenguelli, BG 2001,

'Modulation of native and recombinant GABAA receptors by endogenous and synthetic neuroactive steroids' Brain Research Reviews, vol. 37, no. 1-3, pp. 68-80.
https://doi.org/10.1016/S0165-0173(01)00124-2

Research output: Contribution To Journal



Anderson, A, Belelli, D, Bennett, J, Buchanan, KI, Casula, A, Cooke, A, Feilden, H, Gemmell, DK, Hamilton, NM, Hutchinson, EJ, Lambert, JJ, Maidment, MS, Mc Guire, R, Mc Phail, P, Miller, S, Muntoni, A, Peters, JA, Sansbury, FH, Stevenson, D & Sundaramt, H 2001,

'α-amino acid phenolic ester derivatives: Novel water-soluble general anesthetic agents which allosterically modulate gabaa receptors' Journal of Medicinal Chemistry, vol. 44, no. 22, pp. 3582-3591.
https://doi.org/10.1021/jm010903i

Research output: Contribution To Journal



Rego, AC, Lambert, JJ & Nicholls, DG 2001,

'Developmental profile of excitatory GABAA responses in cultured rat cerebellar granule cells' Neuro Report, vol. 12, no. 3, pp. 477-482.
https://doi.org/10.1097/00001756-200103050-00011

Research output: Contribution To Journal



Lambert, J, Harney, SC, Belelli, D & Peters, JA 2001,

'Neurosteroid modulation of recombinant and synaptic GABAA receptors' International Review of Neurobiology, vol. 46, pp. 177-205.
https://doi.org/10.1016/S0074-7742(01)46063-6

Research output: Contribution To Journal



Gunthorpe, MJ, Peters, JA, Gill, CH, Lambert, JJ & Lummis, SCR 2000,

'The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-MT(3A) receptors' Journal of Physiology, vol. 522, no. 2, pp. 187-198.
https://doi.org/10.1111/j.1469-7793.2000.00187.x

Research output: Contribution To Journal



Belelli, D, Pistis, M, Peters, JA & Lambert, JJ 1999,

'General anaesthetic action at transmitter-gated inhibitory amino acid receptors' Trends in Pharmacological Sciences, vol. 20, no. 12, pp. 496-502.
https://doi.org/10.1016/S0165-6147(99)01405-4

Research output: Contribution To Journal



Dunn, SMJ, Davies, M, Muntoni, AL & Lambert, JJ 1999,

'Mutagenesis of the rat α1 subunit of the γ-aminobutyric acid(A) receptor reveals the importance of residue 101 in determining the allosteric effects of benzodiazepine site ligands' Molecular Pharmacology, vol. 56, no. 4, pp. 768-774.

Research output: Contribution To Journal



Belelli, D, Pau, D, Cabras, G, Peters, JA & Lambert, JJ 1999,

'A single amino acid confers barbiturate sensitivity upon the GABA ρ1 receptor' British Journal of Pharmacology, vol. 127, no. 3, pp. 601-604.
https://doi.org/10.1038/sj.bjp.0702611

Research output: Contribution To Journal



Belelli, D, Pistis, M, Peters, JA & Lambert, JJ 1999,

'The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors' Neurochemistry International, vol. 34, no. 5, pp. 447-452.
https://doi.org/10.1016/S0197-0186(99)00037-6

Research output: Contribution To Journal



Pistis, M, Belelli, D, Mc Gurk, K, Peters, JA & Lambert, JJ 1999,

'Complementary regulation of anaesthetic activation of human (α6β3γ(2L)) and Drosophila (RDL) GABA receptors by a single amino acid residue' Journal of Physiology, vol. 515, no. 1, pp. 3-18.
https://doi.org/10.1111/j.1469-7793.1999.003ad.x

Research output: Contribution To Journal



Davies, PA, Pistis, M, Hanna, MC, Peters, JA, Lambert, JJ, Hales, TG & Kirkness, EF 1999,

'The S-HT3B subunit is a major determinant of serotonin-receptor function' Nature, vol. 397, no. 6717, pp. 359-363.
https://doi.org/10.1038/16941

Research output: Contribution To Journal



Hope, AG, Belelli, D, Mair, ID, Lambert, JJ & Peters, JA 1999,

'Molecular determinants of (+)-tubocurarine binding at recombinant 5- hydroxytryptamine(3A) receptor subunits' Molecular Pharmacology, vol. 55, no. 6, pp. 1037-1043.
https://doi.org/10.1124/mol.55.6.1037

Research output: Contribution To Journal



Mair, ID, Lambert, JJ, Yang, J, Dempster, J & Peters, JA 1998,

'Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT(3A(b)) expressed in Xenopus laevis oocytes' British Journal of Pharmacology, vol. 124, no. 8, pp. 1667-1674.
https://doi.org/10.1038/sj.bjp.0702037

Research output: Contribution To Journal



Mc Gurk, KA, Pistis, M, Belelli, D, Hope, AG & Lambert, JJ 1998,

'The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor' British Journal of Pharmacology, vol. 124, no. 1, pp. 13-20.
https://doi.org/10.1038/sj.bjp.0701787

Research output: Contribution To Journal



Brown, AM, Hope, AG, Lambert, JJ & Peters, JA 1998,

'Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT(3A))' Journal of Physiology, vol. 507, no. 3, pp. 653-665.
https://doi.org/10.1111/j.1469-7793.1998.653bs.x

Research output: Contribution To Journal



Peters, JA & Lambert, JJ 1997,

'Anaesthetics in a bind?' Trends in Pharmacological Sciences, vol. 18, no. 12, pp. 453-455.
https://doi.org/10.1016/S0165-6147(97)01135-8

Research output: Contribution To Journal



Pistis, M, Belelli, D, Peters, JA & Lambert, JJ 1997,

'The interaction of general anaesthetics with recombinant GABA(A) and glycine receptors expressed in Xenopus laevis oocytes: A comparative study' British Journal of Pharmacology, vol. 122, no. 8, pp. 1707-1719.
https://doi.org/10.1038/sj.bjp.0701563

Research output: Contribution To Journal



Belelli, D, Lambert, JJ, Peters, JA, Wafford, K & Whiting, PJ 1997,

'The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid' Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 20, pp. 11031-11036.
https://doi.org/10.1073/pnas.94.20.11031

Research output: Contribution To Journal



Anderson, A, Boyd, AC, Byford, A, Campbell, AC, Gemmell, DK, Hamilton, NM, Hill, DR, Hill-Venning, C, Lambert, JJ, Maidment, MS, May, V, Marshall, RJ, Peters, JA, Rees, DC, Stevenson, D & Sundaram, H 1997,

'Anesthetic activity of novel water-soluble 2β-morpholinyl steroids and their modulatory effects at GABA(A) receptors' Journal of Medicinal Chemistry, vol. 40, no. 11, pp. 1668-1681.
https://doi.org/10.1021/jm960733n

Research output: Contribution To Journal



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