Jenni Harvey

+44 (0)1382 383359
Senior Lecturer in Neuroscience

Bio

Biography

Jenni Harvey obtained a BSc honours degree in Pharmacology at the University of Edinburgh (1990) before receiving a Ph.D. in 1993 for work on metabotropic glutamate receptors and synaptic transmission under the supervision of Prof Graham Collingridge (University of Birmingham). She then undertook postdoctoral research positions with Dr Mike Lacey (University of Birmingham) and Prof Mike AShford (University of Aberdeen), before moving to Dundee to set up her own laboratory after being awarded a Wellcome Research Career Development Fellowship (2001). In 2005, she was awarded a Wellcome University Award to continue her studies into the role of leptin in hippocampal synaptic function.

Teaching

Undergraduate Science Teaching

5th Year MSCi in Pharmacology/Neuroscience

4th year BSc & BMSc Honours in Pharmacology

4th year BSc & BMSc Honours in Neuroscience

Module Course - Synaptic plasticity and cognition

Module Course Leader - Neurodegenerative Disorders

Supervision of 4th year BSc and BMSc Honours Student Projects

3rd year BSc

Quantitative Pharmacology module

Molecular Pharmacology module

Regulatory Physiology and Pharmacology module

Biomembranes module

Undergraduate Medical Student Teaching

1st year Medical Special Study Component (SSC)

1st year tutorials

Supervision of Medical Students in their 4th year laboratory-based assignment

Postgraduate Teaching

I have extensive experience of supervising both MSc and PhD students.

Research

Jenni Harvey’s research group has a long standing interest in neuronal synaptic mechanisms and in particular the cellular basis for activity-dependent synaptic plasticity in the CNS. Her research is focused on understanding how the molecular processes of synaptic plasticity are influenced by hormonal systems in health and disease. Recent studies by the group have highlighted a potential cognitive enhancing role for leptin as it regulates diverse aspects of synaptic function including glutamate receptor trafficking, neuronal morphology and activity dependent synaptic plasticity. A major focus of her current research is in determining the cellular and molecular processes underlying leptin’s effects in the brain and also how dysfunctions in the leptin system impact on brain function. Her group are utilizing a range of techniques including electrophysiology, digital epifluorescence imaging, transgenic mouse technologies, molecular biology and confocal microscopy to determine the neuronal function of the hormone leptin.

Publications

Mc Gregor, G, Clements, L, Farah, A, Irving, A & Harvey, J 2018,

'Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin' Neurobiology of Aging, vol. 69, pp. 76-93. DOI:
10.1016/j.neurobiolaging.2018.05.007

Research output: Contribution To Journal



Mc Gregor, G & Harvey, J 2017,

'Food for thought: Leptin regulation of hippocampal function and its role in Alzheimer's disease' Neuropharmacology. DOI:
10.1016/j.neuropharm.2017.09.038

Research output: Contribution To Journal



Mcgregor, G & Harvey, J 2017,

'Leptin Regulation of Synaptic Function at Hippocampal TA-CA1 and SC-CA1 Synapses: Implications for Health and Disease' Neurochemical Research. DOI:
10.1007/s11064-017-2362-1

Research output: Contribution To Journal



Mc Gregor, G, Irving, AJ & Harvey, J 2017,

'Canonical JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synapses' FASEB Journal, vol. 31, no. 8, pp. 3449-3466. DOI:
10.1096/fj.201601293RR

Research output: Contribution To Journal



Irving, A, Abdulrazzaq, G, Chan, SLF, Penman, J, Harvey, J & Alexander, SPH 2017,

Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors. in D Kendall & SPH Alexander (eds), Cannabinoid Pharmacology. vol. 80, Advances in Pharmacology, vol. 80, Academic Press, Cambridge, MA, pp. 223-247. DOI:
10.1016/bs.apha.2017.04.004

Research output: Contribution To Book Anthology



Alexander, A, Irving, AJ & Harvey, J 2017,

'Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS' Neuropharmacology, vol. 113, no. Part B, pp. 652-660. DOI:
10.1016/j.neuropharm.2016.07.003

Research output: Contribution To Journal



Malekizadeh, Y, Holiday, A, Redfearn, D, Ainge, JA, Doherty, G & Harvey, J 2016,

'A Leptin Fragment Mirrors the Cognitive Enhancing and Neuroprotective Actions of Leptin' Cerebral Cortex, vol. 27, no. 10, pp. 4769-4782. DOI:
10.1093/cercor/bhw272

Research output: Contribution To Journal



Luo, X, Mc Gregor, G, Irving, AJ & Harvey, J 2015,

'Leptin induces a novel form of NMDA receptor-dependent LTP at hippocampal termporoammonic-CA1 synapses' e Neuro, vol. 2, no. 3. DOI:
10.1523/ENEURO.0007-15.2015

Research output: Contribution To Journal



Mc Gregor, G, Malekizadeh, Y & Harvey, J 2015,

'Minireview: food for thought: regulation of synaptic function by metabolic hormones' Molecular Endocrinology, vol. 29, no. 1, pp. 3-13. DOI:
10.1210/me.2014-1328

Research output: Contribution To Journal



Palmer, MJ & Harvey, J 2014,

'Honeybee Kenyon cells are regulated by a tonic GABA receptor conductance' Journal of Neurophysiology, vol. 112, no. 8, pp. 2026-2035. DOI:
10.1152/jn.00180.2014

Research output: Contribution To Journal



Irving, AJ & Harvey, J 2014,

'Leptin regulation of hippocampal synaptic function in health and disease' Philosophical Transactions of the Royal Society B - Biological Sciences, vol. 369, no. 1633, 20130155. DOI:
10.1098/rstb.2013.0155

Research output: Contribution To Journal



Palmer, MJ, Moffat, C, Saranzewa, N, Harvey, J, Wright, GA & Connolly, CN 2013,

'Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees' Nature Communications, vol. 4, 1634. DOI:
10.1038/ncomms2648

Research output: Contribution To Journal



Doherty, GH, Beccano-Kelly, D, Yan, S-D, Gunn-Moore, F & Harvey, J 2013,

'Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β.' Neurobiology of Aging, vol. 34, no. 1, pp. 226-37. DOI:
10.1016/j.neurobiolaging.2012.08.003

Research output: Contribution To Journal



Blair, PJ & Harvey, J 2012,

'PTEN: a new player controlling structural and functional synaptic plasticity' Journal of Physiology, vol. 590, no. 5, pp. 1017-1017. DOI:
10.1113/jphysiol.2012.227868

Research output: Contribution To Journal



Moult, PR & Harvey, J 2011,

'NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity' Neuropharmacology, vol. 61, no. 5-6, pp. 924-936. DOI:
10.1016/j.neuropharm.2011.06.021

Research output: Contribution To Journal



Harvey, J 2010,

'Leptin: The Missing Link in Alzheimer Disease?' Clinical Chemistry, vol. 56, no. 5, pp. 696-697. DOI:
10.1373/clinchem.2010.144006

Research output: Contribution To Journal



Moult, PR, Cross, A, Santos, SD, Carvalho, A-L, Lindsay, Y, Connolly, CN, Irving, AJ, Leslie, NR & Harvey, J 2010,

'Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition' Journal of Neuroscience, vol. 30, no. 11, pp. 4088-4101. DOI:
10.1523/JNEUROSCI.3614-09.2010

Research output: Contribution To Journal



Moult, PR & Harvey, J 2009,

'Regulation of glutamate receptor trafficking by leptin' Biochemical Society Transactions, vol. 37, pp. 1364-1368. DOI:
10.1042/BST0371364

Research output: Contribution To Journal



Moult, PR, Milojkovic, B & Harvey, J 2009,

'Leptin reverses long-term potentiation at hippocampal CA1 synapses' Journal of Neurochemistry, vol. 108, no. 3, pp. 685-696. DOI:
10.1111/j.1471-4159.2008.05810.x

Research output: Contribution To Journal



Solovyova, N, Moult, PR, Milojkovic, B, Lambert, JJ & Harvey, J 2009,

'Bi-directional modulation of fast inhibitory synaptic transmission by leptin' Journal of Neurochemistry, vol. 108, no. 1, pp. 190-201. DOI:
10.1111/j.1471-4159.2008.05751.x

Research output: Contribution To Journal



Moult, PR & Harvey, J 2008,

'Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity' Cell Adhesion and Migration, vol. 2, no. 4, pp. 269-275. DOI:
10.4161/cam.2.4.6354

Research output: Contribution To Journal



Doherty, GH, Oldreive, C & Harvey, J 2008,

'Neuroprotective actions of leptin on central and peripheral neurons in vitro' Neuroscience, vol. 154, no. 4, pp. 1297-1307. DOI:
10.1016/j.neuroscience.2008.04.052

Research output: Contribution To Journal



Oldreive, CE, Harvey, J & Doherty, GH 2008,

'Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro' Neuroscience Letters, vol. 438, no. 1, pp. 17-21. DOI:
10.1016/j.neulet.2008.04.045

Research output: Contribution To Journal



Harvey, J 2008,

'Introduction to Recent Advances in the Cellular and Molecular Mechanisms Underlying Synaptic Plasticity' Cell Adhesion and Migration, vol. 2, no. 4, pp. 268-268. DOI:
10.4161/cam.2.4.7407

Research output: Contribution To Journal



Harvey, J & Withers, DJ (eds) 2008, Neurobiology of obesity. Cambridge University Press, Cambridge. DOI:
10.1017/CBO9780511541643

Research output: Book Anthology



Harvey, J 2007,

'Leptin regulation of neuronal excitability and cognitive function' Current Opinion in Pharmacology, vol. 7, no. 6, pp. 643-647. DOI:
10.1016/j.coph.2007.10.006

Research output: Contribution To Journal



Greenwood, SM, Mizielinska, SM, Frenguelli, BG, Harvey, J & Connolly, CN 2007,

'Mitochondrial dysfunction and dendritic beading during neuronal toxicity' Journal of Biological Chemistry, vol. 282, no. 36, pp. 26235-26244. DOI:
10.1074/jbc.M704488200

Research output: Contribution To Journal



O'Malley, D, Mac Donald, N, Mizielinska, S, Connolly, CN, Irving, AJ & Harvey, J 2007,

'Leptin promotes rapid dynamic changes in hippocampal dendritic morphology' Molecular and Cellular Neuroscience, vol. 35, no. 4, pp. 559-572. DOI:
10.1016/j.mcn.2007.05.001

Research output: Contribution To Journal



Harvey, J 2007,

'Leptin: a diverse regulator of neuronal function' Journal of Neurochemistry, vol. 100, no. 2, pp. 307-313. DOI:
10.1111/j.1471-4159.2006.04205.x

Research output: Contribution To Journal



O'Malley, D & Harvey, J 2007,

'MAPK-dependent actin cytoskeletal reorganization underlies BK channel activation by insulin' European Journal of Neuroscience, vol. 25, no. 3, pp. 673-682. DOI:
10.1111/j.1460-9568.2007.05347.x

Research output: Contribution To Journal



O'Malley, D, Irving, AJ & Harvey, J 2005,

'Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels' FASEB Journal, vol. 19, no. 11, pp. 1917-1919. DOI:
10.1096/fj.05-4166fje

Research output: Contribution To Journal



Kinsella, JM, Laidlaw, HA, Tang, T, Harvey, J, Sutherland, C & Ashford, MLJ 2004,

'The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1' BMC Clinical Pharmacology, vol. 4, no. 17. DOI:
10.1186/1471-2210-4-17

Research output: Contribution To Journal



Harvey, J & Ashford, MLJ 2003,

'Leptin in the CNS: much more than a satiety signal' Neuropharmacology, vol. 44, no. 7, pp. 845-54. DOI:
10.1016/S0028-3908(03)00076-5

Research output: Contribution To Journal



Shanley, LJ, O'Malley, D, Irving, AJ, Ashford, ML & Harvey, J 2002,

'Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels' Journal of Physiology, vol. 545, no. 3, pp. 933-944. DOI:
10.1113/jphysiol.2002.029488

Research output: Contribution To Journal



Shanley, LJ, Irving, AJ, Rae, MG, Ashford, MLJ & Harvey, J 2002,

'Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels' Nature Neuroscience, vol. 5, no. 4, pp. 299-300. DOI:
10.1038/nn824

Research output: Contribution To Journal



Shanley, LJ, Irving, AJ & Harvey, J 2001,

'Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity' Journal of Neuroscience, vol. 21, no. 24, pp. RC186-1-RC186-6.

Research output: Contribution To Journal



Harvey, J, Mc Kay, NG, Walker, KS, Van der Kaay, J, Downes, CP & Ashford, MLJ 2000,

'Essential role of phosphoinositide 3-kinase in leptin-induced KATP channel activation in the rat CRI-G1 insulinoma cell line' Journal of Biological Chemistry, vol. 275, no. 7, pp. 4660-4669. DOI:
10.1074/jbc.275.7.4660

Research output: Contribution To Journal



Harvey, J, Hardy, SC, Irving, AJ & Ashford, MLJ 2000,

'Leptin activation of ATP-sensitive K+ (KATP) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton' Journal of Physiology, vol. 527, no. 1, pp. 95-107. DOI:
10.1111/j.1469-7793.2000.00095.x

Research output: Contribution To Journal



Harvey, J, Hardy, SC & Ashford, ML 1999,

'Dual actions of the metabolic inhibitor, sodium azide on KATP channel currents in the rat CRI-G1 insulinoma cell line' British Journal of Pharmacology, vol. 126, no. 1, pp. 51-60. DOI:
10.1038/sj.bjp.0702267

Research output: Contribution To Journal



Harvey, J & Ashford, MLJ 1998,

'Insulin occludes leptin activation of ATP-sensitive K+ channels in rat CRI-G1 insulin secreting cells' Journal of Physiology, vol. 511 , no. 3, pp. 695-706. DOI:
10.1111/j.1469-7793.1998.695bg.x

Research output: Contribution To Journal



Harvey, J & Ashford, MLJ 1998,

'Diazoxide- and leptin-activated KATP currents exhibit differential sensitivity to englitazone and ciclazindol in the rat CRI-G1 insulin-secreting cell line' British Journal of Pharmacology, vol. 124, no. 7, pp. 1557-1565. DOI:
10.1038/sj.bjp.0702000

Research output: Contribution To Journal



Harvey, J & Ashford, MLJ 1998,

'Role of tyrosine phosphorylation in leptin activation of ATP-sensitive K+ channels in the rat insulinoma cell line CRI-G1' Journal of Physiology, vol. 510, no. 1, pp. 47-61. DOI:
10.1111/j.1469-7793.1998.047bz.x

Research output: Contribution To Journal



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