Jenni Harvey obtained a BSc honours degree in Pharmacology at the University of Edinburgh (1990) before receiving a Ph.D. in 1993 for work on metabotropic glutamate receptors and synaptic transmission under the supervision of Prof Graham Collingridge (University of Birmingham). She then undertook postdoctoral research positions with Dr Mike Lacey (University of Birmingham) and Prof Mike AShford (University of Aberdeen), before moving to Dundee to set up her own laboratory after being awarded a Wellcome Research Career Development Fellowship (2001). In 2005, she was awarded a Wellcome University Award to continue her studies into the role of leptin in hippocampal synaptic function.
Undergraduate Science Teaching
5th Year MSCi in Pharmacology/Neuroscience
4th year BSc & BMSc Honours in Pharmacology
4th year BSc & BMSc Honours in Neuroscience
Module Course - Synaptic plasticity and cognition
Module Course Leader - Neurodegenerative Disorders
Supervision of 4th year BSc and BMSc Honours Student Projects
3rd year BSc
Quantitative Pharmacology module
Molecular Pharmacology module
Regulatory Physiology and Pharmacology module
Undergraduate Medical Student Teaching
1st year Medical Special Study Component (SSC)
1st year tutorials
Supervision of Medical Students in their 4th year laboratory-based assignment
I have extensive experience of supervising both MSc and PhD students.
Jenni Harvey’s research group has a long standing interest in neuronal synaptic mechanisms and in particular the cellular basis for activity-dependent synaptic plasticity in the CNS. Her research is focused on understanding how the molecular processes of synaptic plasticity are influenced by hormonal systems in health and disease. Recent studies by the group have highlighted a potential cognitive enhancing role for leptin as it regulates diverse aspects of synaptic function including glutamate receptor trafficking, neuronal morphology and activity dependent synaptic plasticity. A major focus of her current research is in determining the cellular and molecular processes underlying leptin’s effects in the brain and also how dysfunctions in the leptin system impact on brain function. Her group are utilizing a range of techniques including electrophysiology, digital epifluorescence imaging, transgenic mouse technologies, molecular biology and confocal microscopy to determine the neuronal function of the hormone leptin.
'Regulation of hippocampal synaptic function by the metabolic hormone, leptin: Implications for health and neurodegenerative disease' Frontiers in Cellular Neuroscience, vol. 12, 340.
'Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin' Neurobiology of Aging, vol. 69, pp. 76-93.
'Food for thought: Leptin regulation of hippocampal function and its role in Alzheimer's disease' Neuropharmacology.
'Leptin Regulation of Synaptic Function at Hippocampal TA-CA1 and SC-CA1 Synapses: Implications for Health and Disease' Neurochemical Research.
'Canonical JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synapses' FASEB Journal, vol. 31, no. 8, pp. 3449-3466.
Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors. in D Kendall & SPH Alexander (eds), Cannabinoid Pharmacology. vol. 80, Advances in Pharmacology, vol. 80, Academic Press, Cambridge, MA, pp. 223-247.
'Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS' Neuropharmacology, vol. 113, no. Part B, pp. 652-660.
'A Leptin Fragment Mirrors the Cognitive Enhancing and Neuroprotective Actions of Leptin' Cerebral Cortex, vol. 27, no. 10, pp. 4769-4782.
'Leptin induces a novel form of NMDA receptor-dependent LTP at hippocampal termporoammonic-CA1 synapses' e Neuro, vol. 2, no. 3.
'Minireview: food for thought: regulation of synaptic function by metabolic hormones' Molecular Endocrinology, vol. 29, no. 1, pp. 3-13.
'Honeybee Kenyon cells are regulated by a tonic GABA receptor conductance' Journal of Neurophysiology, vol. 112, no. 8, pp. 2026-2035.
'Leptin regulation of hippocampal synaptic function in health and disease' Philosophical Transactions of the Royal Society B - Biological Sciences, vol. 369, no. 1633, 20130155.
'Cholinergic pesticides cause mushroom body neuronal inactivation in honeybees' Nature Communications, vol. 4, 1634.
'Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β.' Neurobiology of Aging, vol. 34, no. 1, pp. 226-37.
'PTEN: a new player controlling structural and functional synaptic plasticity' Journal of Physiology, vol. 590, no. 5, pp. 1017-1017.
'NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity' Neuropharmacology, vol. 61, no. 5-6, pp. 924-936.
'Leptin: The Missing Link in Alzheimer Disease?' Clinical Chemistry, vol. 56, no. 5, pp. 696-697.
'Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition' Journal of Neuroscience, vol. 30, no. 11, pp. 4088-4101.
'Regulation of glutamate receptor trafficking by leptin' Biochemical Society Transactions, vol. 37, pp. 1364-1368.
'Leptin reverses long-term potentiation at hippocampal CA1 synapses' Journal of Neurochemistry, vol. 108, no. 3, pp. 685-696.
'Bi-directional modulation of fast inhibitory synaptic transmission by leptin' Journal of Neurochemistry, vol. 108, no. 1, pp. 190-201.
'Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity' Cell Adhesion and Migration, vol. 2, no. 4, pp. 269-275.
'Neuroprotective actions of leptin on central and peripheral neurons in vitro' Neuroscience, vol. 154, no. 4, pp. 1297-1307.
'Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro' Neuroscience Letters, vol. 438, no. 1, pp. 17-21.
'Introduction to Recent Advances in the Cellular and Molecular Mechanisms Underlying Synaptic Plasticity' Cell Adhesion and Migration, vol. 2, no. 4, pp. 268-268.
'Leptin regulation of neuronal excitability and cognitive function' Current Opinion in Pharmacology, vol. 7, no. 6, pp. 643-647.
'Mitochondrial dysfunction and dendritic beading during neuronal toxicity' Journal of Biological Chemistry, vol. 282, no. 36, pp. 26235-26244.
'Leptin promotes rapid dynamic changes in hippocampal dendritic morphology' Molecular and Cellular Neuroscience, vol. 35, no. 4, pp. 559-572.
'Leptin: a diverse regulator of neuronal function' Journal of Neurochemistry, vol. 100, no. 2, pp. 307-313.
'MAPK-dependent actin cytoskeletal reorganization underlies BK channel activation by insulin' European Journal of Neuroscience, vol. 25, no. 3, pp. 673-682.
'Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels' FASEB Journal, vol. 19, no. 11, pp. 1917-1919.
'The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1' BMC Clinical Pharmacology, vol. 4, no. 17.
'Leptin in the CNS: much more than a satiety signal' Neuropharmacology, vol. 44, no. 7, pp. 845-54.
'Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels' Journal of Physiology, vol. 545, no. 3, pp. 933-944.
'Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels' Nature Neuroscience, vol. 5, no. 4, pp. 299-300.
'Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity' Journal of Neuroscience, vol. 21, no. 24, pp. RC186-1-RC186-6.
'Essential role of phosphoinositide 3-kinase in leptin-induced KATP channel activation in the rat CRI-G1 insulinoma cell line' Journal of Biological Chemistry, vol. 275, no. 7, pp. 4660-4669.
'Leptin activation of ATP-sensitive K+ (KATP) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton' Journal of Physiology, vol. 527, no. 1, pp. 95-107.
'Dual actions of the metabolic inhibitor, sodium azide on KATP channel currents in the rat CRI-G1 insulinoma cell line' British Journal of Pharmacology, vol. 126, no. 1, pp. 51-60.
'Insulin occludes leptin activation of ATP-sensitive K+ channels in rat CRI-G1 insulin secreting cells' Journal of Physiology, vol. 511 , no. 3, pp. 695-706.
'Diazoxide- and leptin-activated KATP currents exhibit differential sensitivity to englitazone and ciclazindol in the rat CRI-G1 insulin-secreting cell line' British Journal of Pharmacology, vol. 124, no. 7, pp. 1557-1565.
'Role of tyrosine phosphorylation in leptin activation of ATP-sensitive K+ channels in the rat insulinoma cell line CRI-G1' Journal of Physiology, vol. 510, no. 1, pp. 47-61.