Jenni Harvey

+44 (0)1382 383359
Senior Lecturer in Neuroscience

Bio

Biography

Jenni Harvey obtained a BSc honours degree in Pharmacology at the University of Edinburgh (1990) before receiving a Ph.D. in 1993 for work on metabotropic glutamate receptors and synaptic transmission under the supervision of Prof Graham Collingridge (University of Birmingham). She then undertook postdoctoral research positions with Dr Mike Lacey (University of Birmingham) and Prof Mike AShford (University of Aberdeen), before moving to Dundee to set up her own laboratory after being awarded a Wellcome Research Career Development Fellowship (2001). In 2005, she was awarded a Wellcome University Award to continue her studies into the role of leptin in hippocampal synaptic function.

Teaching

Undergraduate Science Teaching

5th Year MSCi in Pharmacology/Neuroscience

4th year BSc & BMSc Honours in Pharmacology

4th year BSc & BMSc Honours in Neuroscience

Module Course - Synaptic plasticity and cognition

Module Course Leader - Neurodegenerative Disorders

Supervision of 4th year BSc and BMSc Honours Student Projects

3rd year BSc

Quantitative Pharmacology module

Molecular Pharmacology module

Regulatory Physiology and Pharmacology module

Biomembranes module

Undergraduate Medical Student Teaching

1st year Medical Special Study Component (SSC)

1st year tutorials

Supervision of Medical Students in their 4th year laboratory-based assignment

Postgraduate Teaching

I have extensive experience of supervising both MSc and PhD students.

Research

Jenni Harvey’s research group has a long standing interest in neuronal synaptic mechanisms and in particular the cellular basis for activity-dependent synaptic plasticity in the CNS. Her research is focused on understanding how the molecular processes of synaptic plasticity are influenced by hormonal systems in health and disease. Recent studies by the group have highlighted a potential cognitive enhancing role for leptin as it regulates diverse aspects of synaptic function including glutamate receptor trafficking, neuronal morphology and activity dependent synaptic plasticity. A major focus of her current research is in determining the cellular and molecular processes underlying leptin’s effects in the brain and also how dysfunctions in the leptin system impact on brain function. Her group are utilizing a range of techniques including electrophysiology, digital epifluorescence imaging, transgenic mouse technologies, molecular biology and confocal microscopy to determine the neuronal function of the hormone leptin.

Publications

Regulation of hippocampal synaptic function by the metabolic hormone, leptin
9/2018, Frontiers in Cellular Neuroscience
Research Output: Contribution To Journal > Review article

Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin
5/2018, Neurobiology of Aging
Research Output: Contribution To Journal > Article

Food for thought
8/2017, Neuropharmacology
Research Output: Contribution To Journal > Review article

Leptin Regulation of Synaptic Function at Hippocampal TA-CA1 and SC-CA1 Synapses
7/2017, Neurochemical Research
Research Output: Contribution To Journal > Article

Canonical JAK-STAT signaling is pivotal for long-term depression at adult hippocampal temporoammonic-CA1 synapses
12/2016, FASEB Journal
Research Output: Contribution To Journal > Article

Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors
4/2017
Research Output: Contribution To Book Anthology > Chapter (peer-reviewed)

Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS
2/2016, Neuropharmacology
Research Output: Contribution To Journal > Article

A Leptin Fragment Mirrors the Cognitive Enhancing and Neuroprotective Actions of Leptin
8/2016, Cerebral Cortex
Research Output: Contribution To Journal > Article

Leptin induces a novel form of NMDA receptor-dependent LTP at hippocampal termporoammonic-CA1 synapses
5/2015, eNeuro
Research Output: Contribution To Journal > Article

Minireview
12/2014, Molecular Endocrinology
Research Output: Contribution To Journal > Article

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