Jasbani Dayal

+44 (0)1382 383689
Postdoctoral Research Assistant

Biography

· Postdoctoral researcher: University of Dundee, Feb 2011- present

· PhD: University of Dundee, UK: February 2011

· Master of Science in Biotechnology: University of Abertay Dundee, UK: November, 2005

· Bachelor of Science (Honours) Biotechnology: Amity Institute of Biotechnology (Chaudhary Charan Singh University, Meerut), India: August, 2004. Award: 1st

· Senior Secondary Certificate Examination: Mater Dei School, Delhi (India): July, 2001. Award: 1st; Distinction in Chemistry

· Higher Secondary Certificate Examination: Mater Dei School, Delhi (India): June, 1999. Award: 1st; Distinction

Research

RDEB is a rare inherited skin disorder characterized by mutation in the basement membrane associated protein, type VII collagen. RDEB patients are predisposed to developing aggressive cutaneous squamous cell carcinoma (cSCC) resulting in a 90% mortality rate by the age of 55. There are no targeted therapies available for RDEB cSCC patients and surgical intervention, chemotherapy and radiation therapy have not proved successful. Current research involves elucidating the role of TGF? in RDEB disease progression in Dr Gareth J Inman lab.

Lectures and conferences

· Quantifying multiclonality in drug resistant cSCC using high-throughput analysis of karyotypic heterogeneity: Scottish Skin Biology Club (June 2015), Dundee, UK

· The organic anion transporter, SLCO1B3, is regulated by type VII collagen expression in aggressive cutaneous Squamous Cell Carcinoma: British Society of Investigative Dermatology (April 2012), Exeter University, UK

· Type VII collagen regulates front-to-rear polarity in aggressive cutaneous squamous cell carcinoma through modulation of key polarity proteins: Scottish Skin Biology club (November 2012), Glasgow University, UK

· Comparing clinical outcome to genetic instability and the der(1;16) chromosome in primary breast cancer: Postgraduate symposium (June 2010), University of Dundee, UK.

· The application of triple stain flow cytometry and high resolution aCGH in primary breast cancer: Agilent technologies road show (June 2010), Novotel Hotel, London, UK.

· High DNA content is associated with poor prognostic features in primary breast cancer: Scottish Genetics meeting (November 2009), Westpark Centre, Dundee, UK.

· Co-application of flow cytometry and aCGH in breast cancer: University of Manchester, Agilent training, Nowgen centre (March 2009), Manchester, UK.

· Linking cytogenetic abnormalities to p53 mutations and clinical outcome in breast cancer: Postgraduate symposium (June 2008), Ninewells Hospital, Dundee, UK.

· Linking cytogenetic abnormalities to p53 mutations and clinical outcome in breast cancer: Genetics Research group (September 2007), Ninewells hospital, Dundee, UK

Conference Poster presentations

· Type VII collagen regulates front-to-rear polarity in aggressive cutaneous squamous cell carcinoma through modulation of key polarity proteins: International Investigative Dermatology conference (April 2013)

· Type VII collagen regulates front-to-rear polarity in aggressive cutaneous squamous cell carcinoma through modulation of key polarity proteins: National Cancer Research Institute conference (November 2012)

· SLCO1B3, an organic anion transporter, is regulated by type V11 collagen in aggressive cutaneous Squamous Cell Carcinoma. National Cancer Research Institute conference (November 2011), Liverpool, UK

· Evaluation of der(1;16)(q10;p10) chromosome rearrangement in breast cancer National Cancer Research Institute conference (October 2010), Liverpool, UK

· Cytogenetic abnormalities associated with p53 mutation in primary breast cancers: National Cancer Research Institute conference (October 2010), Liverpool, UK

· Gain of 16p11.2 region associates with oestrogen receptor and progesterone receptor positive status in primary breast cancer: National Cancer Research Institute conference (October 2010), Liverpool, UK

Publications

· Dayal JH, Cole CL, Pourreyron C, Watt SA, Lim YZ, Salas-Alanis JC, Murrell DF, McGrath JA, Stieger B, Jahoda C, Leigh IM, South AP (2014) Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes. J Cell Sci 127(Pt 4): 740-51

· Watt SA, Purdie KJ, den Breems NY, Dimon M, Arron ST, McHugh A, Xue DJ, Dayal JH, Proby CM, Harwood CA, Leigh IM, South AP (2015) Novel CARD11 Mutations in Human Cutaneous Squamous Cell Carcinoma Lead to Aberrant NF-kappaB Regulation. Am J Pathol

· South AP, Purdie KJ, Watt SA, Haldenby S, den Breems NY, Dimon M, Arron ST, Kluk MJ, Aster JC, McHugh A, Xue DJ, Dayal JH, Robinson KS, Rizvi SM, Proby CM, Harwood CA, Leigh IM (2014) NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis. J Invest Dermatology

· Dayal, J. H., Sales, M. J., Corver, W. E., Purdie, C. A., Jordan, L. B., Quinlan, P. R., Baker, L., ter Haar, N. T., Pratt, N. R. and Thompson, A. M. (2013). Multiparameter DNA content analysis identifies distinct groups in primary breast cancer. Br J Cancer 108, 873-880.

· Ng YZ, Pourreyron C, Salas-Alanis JC, Dayal JH, Cepeda-Valdes R, Yan W, Wright S, Chen M, Fine JD, Hogg FJ, McGrath JA, Murrell DF, Leigh IM, Lane EB, South AP (2012) Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa. Cancer Res 72(14): 3522-34

· Yi-Zhen Ng, JasbaniH.S Dayal and Andrew P. South (2011). Genetic Predisposition to Cutaneous Squamous Cell Carcinoma, Skin Cancers - Risk Factors, Prevention and Therapy, Caterina AM La Porta (Ed.), ISBN: 978-953-307-722-2, InTech, Available from: http://www.intechopen.com/books/skin-cancers-risk-factors-prevention-and-therapy/genetic-predisposition-to-cutaneous-squamous-cell-carcinoma

· Dayal JHS, Sales M., Purdie C, Hislop RG, Thompson AM, Pratt NR. , Flow analysis of aneuploidy and the chromosome instability phenotype. Journal of Medical Genetics, vol 45, supplement 1 pp:s66, British Human Genetics Conference, 2008.