Graham Rena

+44 (0)1382 383546
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Bio

Research interests

Biography

Dr Graham Rena's undergraduate BSc studies were at University of Bristol, followed by Ph.D. studies with Professor Miles Houslay FRSE at the University of Glasgow and postdoctoral work with Professor Sir Philip Cohen FRS, FRSE at the University of Dundee. Graham was a Caledonian Research Foundation Fellow between 2004 and 2007 before staying on to take up a permanent lectureship at the University of Dundee. Graham has been a contributing author on over 30 peer-reviewed publications. The key area of current research is drug repurposing, particularly including recent key insights into metformin action. Graham’s research has attracted grant funding from MRC, BHF Diabetes UK as well as other major funders. Graham enjoys teaching, particularly including innovative international teaching activities in Kuwait.

Research

Repurposing metformin, studies from cells to patients

A major recent focus has been metformin, which is the gold-standard treatment of insulin resistance in type 2 diabetes. Collaborative work particularly with Prof Chim Lang has included investigation of anti-inflammatory effects of the drug, which are likely to contribute towards cardioprotective effects in patients, irrespective of diabetes status. This insight provides an easily understood rationale for further testing of non-diabetic cardiovascular patient groups that may benefit from metformin and has been published in high impact journals (Circulation and Circulation Research)

Lectures and conferences

2018 European Heart Failure Association annual meeting Vienna

2017 “Metformin: heart failure drug?” Translational Research Workshop, Brussels, Belgium

2017 12th Annual Winter Research Meeting of the Heart Failure Association and Working Group on Myocardial Function of the European Society of Cardiology, Les Diablerets, Switzerland

2016 Danish Technical University, Lyngby, Denmark

Impact

PRIZE: Best Manuscript Award at Circulation Research editorial board dinner in New Orleans, November 2016.

Teaching

M.Sc. Dissertation Lead, Quantitative (Kuwait, Dasman Diabetes Institute)

The MSc makes use of modern approaches, including for example a recently generated virtual poster room (see separate picture) 

Life Sciences Teaching: Regulatory Physiology and Pharmacology

Medical School Teaching: BMSc Diabetes and Metabolic Disorders

 

Publications

Heart failure and diabetes : metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology
9/2018, European Heart Journal
Research Output: Contribution To Journal > Article

Regulation of hepatic glucose production and AMPK by AICAR but not metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)
6/2018, Diabetes, Obesity & Metabolism
Research Output: Contribution To Journal > Article

Metformin selectively targets redox control of complex I energy transduction
8/2017, Redox Biology
Research Output: Contribution To Journal > Article

Repurposing metformin for cardiovascular disease
10/2017, Circulation
Research Output: Contribution To Journal > Review article

The mechanisms of action of metformin
3/2017, Diabetologia
Research Output: Contribution To Journal > Review article

New Evidence for the Mechanism of Action of a Type-2 Diabetes Drug Using a Magnetic Bead-Based Automated Biosensing Platform
8/2017, ACS Sensors
Research Output: Contribution To Journal > Article

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
7/2016, Circulation Research
Research Output: Contribution To Journal > Article

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug
1/2016, Biochimica et Biophysica Acta. Molecular Basis of Disease
Research Output: Contribution To Journal > Article

Investigation of metal-binding properties of clinically significant compounds using magnetic bead-based agglutination assay
/2016
Research Output: Contribution To Book Anthology > Conference contribution

The copper binding properties of metformin - QCM-D, XPS and nanobead agglomeration
12/2015, Chemical Communications
Research Output: Contribution To Journal > Article

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Press

Diabetic drug may offer benefits in heart failure

Chim Lang & Graham Rena

2/07/12

1 item of media coverage

Press/Media: Research



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Activities

Diabetes UK Professional Conference 2013

Graham Rena (Participant)
13 Mar 201315 Mar 2013

Activity: Participating in or organising an event typesParticipation in conference

Activity Type: Attendance

Diabetes UK Professional Conference 2012

Graham Rena (Participant)
7 Mar 20129 Mar 2012

Activity: Participating in or organising an event typesParticipation in conference

Activity Type: Attendance

44th General Assembly of the European Association for the Study of Diabetes

Graham Rena (Participant)
10 Sep 2008

Activity: Participating in or organising an event typesParticipation in conference

Activity Type: Attendance

676th Biochemical Society Meeting

Graham Rena (Participant)
8 Apr 200210 Apr 2002

Activity: Participating in or organising an event typesParticipation in conference

Activity Type: Attendance

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