Ewan Pearson

+44 (0)1382 383387
Head of Division - Population Health & Genomics & Professor of Diabetic Medicine & Head of Clinical Translational Science & Director Dundee Clinical Academic Track

Bio

Biography

Ewan Pearson is Professor of Diabetic Medicine at the University of Dundee, Visiting Professor at the University of Edinburgh, and Honorary Consultant in Diabetes and Endocrinology at Ninewells Hospital and Medical School in Dundee.   In the School of Medicine, he is the Head of Division, Population Health & Genomics, and the Director of the Dundee Clinical Academic Track. 

Professor Pearson obtained his medical degree from the University of Cambridge School of Clinical Medicine, UK.  He undertook a Wellcome Trust Clinical Training fellowship with Prof Andrew Hattersley at the University of Exeter Medical School, UK and completed his PhD in the physiology and treatment of monogenic diabetes. He then moved to Dundee where he was supported by a Chief Scientist Office Clinician Scientisit fellowship and, more recently, by a Wellcome Trust Investigator Award.  Over the last ten years in Dundee his research interests have been in the phenotypic and genotypic determinants of drug response in diabetes, and in stratified approaches to the management of diabetes.  He leads the IMI-DIRECT project on stratification in type 2 diabetes and is strand 2 lead on the ABPI-MRC funded MASTERMIND project.  Ewan has been awarded the Royal College of Physicians of Edinburgh Croom Lecture, an EASD Rising Star award, the Diabetes UK RD Lawrence Lecture and the EASD Minkowski Award for his work in these areas.

 

Publications

Patel, KA, Weedon, MN, Shields, BM, Pearson, ER & Hattersley, AT & Mc Donald, TJ 2018,

'Zinc Transporter 8 Autoantibodies (Zn T8A) and a Type 1 Diabetes Genetic Risk Score Can Exclude Individuals With Type 1 Diabetes From Inappropriate Genetic Testing for Monogenic Diabetes' Diabetes Care, pp. e1-e2.
https://doi.org/10.2337/dc18-0373

Research output: Contribution To Journal



Ji, Y, Yiorkas, AM, Frau, F, Mook-Kanamori, D, Staiger, H, Thomas, EL, Atabaki-Pasdar, N, Campbell, A, Tyrrell, J, Jones, SE, Beaumont, RN, Wood, AR, Tuke, MA, Ruth, KS, Mahajan, A, Murray, A, Freathy, RM, Weedon, MN, Hattersley, AT, Hayward, C, Machann, J, Häring, H-U, Franks, P, de Mutsert, R, Pearson, E, Stefan, N, Frayling, TM, Allebrandt, KV, Bell, JD, Blakemore, AI & Yaghootkar, H 2018,

'Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension' Diabetes, vol. 67, no. 11.
https://doi.org/10.2337/db18-0708

Research output: Contribution To Journal



Grubb, AL, Mc Donald, TJ, Rutters, F, Donnelly, L, Hattersley, AT, Oram, RA, Palmer, C, van der Heijden, AA, Carr, F, Elders, PJM, Weedon, M, Slieker, RC, 't Hart, LM, Pearson, E, Shields, BM & Jones, AG 2018,

'A Type 1 Diabetes Genetic Risk Score can identify patients with GAD65 autoantibody positive type 2 diabetes that rapidly progress to insulin therapy' Diabetes Care.
https://doi.org/10.2337/dc18-0431

Research output: Contribution To Journal



Shah, N, Coathup, V, Teare, H, Forgie, I, Giordano, GN, Hansen, TH, Groeneveld, L, Hudson, M, Pearson, E, Ruetten, H & Kaye, J 2018,

'Sharing data for future research-engaging participants' views about data governance beyond the original project: a DIRECT Study' Genetics in Medicine.
https://doi.org/10.1038/s41436-018-0299-7

Research output: Contribution To Journal



Cosentino, C, Toivonen, S, Diaz Villamil, E, Atta, M, Ravanat, J-L, Demine, S, Schiavo, AA, Pachera, N, Deglasse, J-P, Jonas, J-C, Balboa, D, Otonkoski, T, Pearson, ER, Marchetti, P, Eizirik, DL, Cnop, M & Igoillo-Esteve, M 2018,

'Pancreatic β-cell t RNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes' Nucleic Acids Research.
https://doi.org/10.1093/nar/gky839

Research output: Contribution To Journal



Shepherd, MH, Shields, BM, Hudson, M, Pearson, ER, Hyde, C, Ellard, S & Hattersley, AT & Patel, KA 2018,

'A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin' Diabetologia.
https://doi.org/10.1007/s00125-018-4728-6

Research output: Contribution To Journal



Teare, HJA, de Masi, F, Banasik, K, Barnett, A, Herrgard, S, Jablonka, B, Postma, JWM, Mc Donald, TJ, Forgie, I, Chmura, PJ, Rydzka, EK, Gupta, R, Brunak, S, Pearson, E & Kaye, J 2018,

'The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project' Life Sciences, Society and Policy, vol. 14, no. 1.
https://doi.org/10.1186/s40504-018-0083-0

Research output: Contribution To Journal



Scottish Diabetes Research Network Epidemiology Group, Read, SH, van Diepen, M, Colhoun, HM, Halbesma, N, Lindsay, RS, Mc Knight, JA, Mc Allister, DA, Pearson, ER, Petrie, JR, Philip, S, Sattar, N, Woodward, M & Wild, SH 2018,

'Performance of Cardiovascular Disease Risk Scores in People Diagnosed With Type 2 Diabetes: External Validation Using Data From the National Scottish Diabetes Register' Diabetes Care, vol. 41, no. 9, pp. 2010-2018.
https://doi.org/10.2337/dc18-0578

Research output: Contribution To Journal



Rotroff, DM, Yee, SW, Zhou, K, Marvel, SW, Shah, HS, Jack, JR, Havener, TM, Hedderson, MM, Kubo, M, Herman, MA, Gao, H, Mychaleckyi, JC, Mc Leod, HL, Doria, A, Giacomini, KM, Pearson, ER, Wagner, MJ, Buse, JB, Motsinger-Reif, AA & Met Gen Investigators and the ACCORD/ACCORDion Investigators 2018,

'Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes' Diabetes, vol. 67, no. 7, pp. 1428-1440.
https://doi.org/10.2337/db17-1164

Research output: Contribution To Journal



Pearson, E & Adamski, J 2018,

'The search for predictive metabolic biomarkers for incident T2DM' Nature Reviews Endocrinology.
https://doi.org/10.1038/s41574-018-0045-x

Research output: Contribution To Journal



Neonatal Diabetes International Collaborative Group, Bowman, P, Sulen, Å, Barbetti, F, Beltrand, J, Svalastoga, P, Codner, E, Tessmann, EH, Juliusson, PB, Skrivarhaug, T, Pearson, ER, Flanagan, SE, Babiker, T, Thomas, NJ, Shepherd, MH, Ellard, S, Klimes, I, Szopa, M, Polak, M, Iafusco, D, Hattersley, AT & Njølstad, PR 2018,

'Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study' The Lancet Diabetes and Endocrinology.
https://doi.org/10.1016/S2213-8587(18)30106-2

Research output: Contribution To Journal



Pearson, ER 2018,

'Pharmacogenetics and target identification in diabetes' Current Opinion in Genetics & Development, vol. 50, pp. 68-73.
https://doi.org/10.1016/j.gde.2018.02.005

Research output: Contribution To Journal



Siddiqui, MK, Kennedy, G, Carr, F, Doney, A, Pearson, E, Morris, A, Johnson, T, Mc Laughlin, MM, Williams, RE & Palmer, C 2018,

'Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study' Diabetologia, vol. 61, no. 6, pp. 1344-1353.
https://doi.org/10.1007/s00125-018-4601-7

Research output: Contribution To Journal



Hébert, HL, Shepherd, B, Milburn, K, Veluchamy, A, Meng, W, Carr, F, Donnelly, LA, Tavendale, R, Leese, G, Colhoun, HM, Dow, E, Morris, AD, Doney, AS, Lang, CC, Pearson, ER, Smith, BH & Palmer, CNA 2018,

'Cohort Profile: Genetics of Diabetes Audit and Research in Tayside Scotland (Go DARTS)' International Journal of Epidemiology, vol. 47, no. 2, pp. 380-381j.
https://doi.org/10.1093/ije/dyx140

Research output: Contribution To Journal



Corbin, LJ, Tan, VY, Hughes, DA, Wade, K, Paul, DS, Tansey, KE, Butcher, F, Dudbridge, F, Howson, JMM, Jallow, MW, John, C, Kingston, N, Lindgren, CM, O’Donavan, M, O'Rahilly, S, Owen, MJ, Palmer, C, Pearson, E, Scott, RA, van Heel, D, Whittaker, J, Frayling, T, Tobin, MD, Wain, LV, Smith, GD, Evans, DM, Karpe, F, Mc Carthy, MI, Danesh, J, Franks, PW & Timpson, NJ 2018,

'Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference' Nature Communications, vol. 9, 711, pp. 1-11.
https://doi.org/10.1038/s41467-018-03109-y

Research output: Contribution To Journal



Mc Creight, L, Stage, TB, Connelly, P, Lonergan, M, Nielsen, F, Prehn, C, Adamski, J, Brosen, K & Pearson, ER 2018,

'Pharmacokinetics of metformin in patients with gastrointestinal intolerance' Diabetes, Obesity & Metabolism.
https://doi.org/10.1111/dom.13264

Research output: Contribution To Journal



Noyes, JD, Soto-Pedre, E, Donnelly, LA & Pearson, E 2018,

'Characteristics of people with high visit-to-visit glycaemic variability in Type 2 diabetes' Diabetic Medicine, vol. 35, no. 2, pp. 262-267.
https://doi.org/10.1111/dme.13435

Research output: Contribution To Journal



Gudmundsdottir, V, Pedersen, HK, Allebrandt, KV, Brorsson, C, van Leeuwen, N, Banasik, K, Mahajan, A, Groves, CJ, van de Bunt, M, Dawed, AY, Fritsche, A, Staiger, H, Simonis-Bik, AMC, Deelen, J, Kramer, MHH, Dietrich, A, Hübschle, T, Willemsen, G, Häring, H-U, de Geus, EJC, Boomsma, DI, Eekhoff, EMW, Ferrer, J, Mc Carthy, MI, Pearson, ER, Gupta, R, Brunak, S & 't Hart, LM 2018,

'Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study' PLo S ONE, vol. 13, no. 1, e0189886, pp. 1-19.
https://doi.org/10.1371/journal.pone.0189886

Research output: Contribution To Journal



Molnos, S, Wahl, S, Haid, M, Eekhoff, EMW, Pool, R, Floegel, A, Deelen, J, Much, D, Prehn, C, Breier, M, Draisma, HHM, van Leeuwen, N, Simonis-Bik, AMC, Jonsson, A, Willemsen, G, Bernigau, W, Wang-Sattler, R, Suhre, K, Peters, A, Thorand, B, Herder, C, Rathmann, W, Roden, M, Gieger, C, Kramer, MHH, van Heemst, D, Pedersen, HK, Gudmundsdottir, V, Schulze, MB, Pischon, T, de Geus, EJC, Boeing, H, Boomsma, DI, Ziegler, AG, Slagboom, PE, Hummel, S, Beekman, M, Grallert, H, Brunak, S, Mc Carthy, MI, Gupta, R, Pearson, ER, Adamski, J & 't Hart, LM 2018,

'Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study' Diabetologia, vol. 61, no. 1, pp. 117-129.
https://doi.org/10.1007/s00125-017-4436-7

Research output: Contribution To Journal



Dennis, JM, Shields, BM, Hill, AV, Knight, BA, Mc Donald, TJ, Rodgers, LR, Weedon, MN, Henley, WE, Sattar, N, Holman, RR, Pearson, ER, Hattersley, AT, Jones, AG & MASTERMIND consortium 2018,

'Precision Medicine in Type 2 Diabetes: Clinical Markers of Insulin Resistance Are Associated With Altered Short- and Long-Term Glycemic Response to DPP-4 Inhibitor Therapy' Diabetes Care, vol. 41, no. 4, pp. 705-712.
https://doi.org/10.2337/dc17-1827

Research output: Contribution To Journal



Marzetti, M, Brunton, T, Mc Creight, L, Pearson, E, Docherty, S & Gandy, SJ 2018,

'Quantitative MRI evaluation of whole abdomen adipose tissue volumes in healthy volunteers-validation of technique and implications for clinical studies' British Journal of Radiology, vol. 91, no. 1087, 20180025.
https://doi.org/10.1259/bjr.20180025

Research output: Contribution To Journal



Siddiqui, MK, Maroteau, C, Veluchamy, A, Tornio, A, Tavendale, R, Carr, F, Abelega, N-U, Carr, D, Bloch, K, Halberg, P, Yue, Q-Y, Pearson, ER, Colhoun, HM, Morris, AD, Dow, E, George, J, Pirmohamed, M, Ridker, PM, Doney, ASF, Alfirevic, A, Wadelius, M, Maitland-van der Zee, AH, Chasman, DI, Palmer, CNA & on behalf of the PREDICTION-ADR Consortium 2017,

'A common missense variant of LILRB5 is associated with statin intolerance and myalgia' European Heart Journal, vol. 38, no. 48, pp. 3569-3575.
https://doi.org/10.1093/eurheartj/ehx467

Research output: Contribution To Journal



Donnelly, LA, Zhou, K, Doney, ASF, Jennison, C, Franks, PW & Pearson, ER 2017,

'Rates of glycaemic deterioration in a real-world population with type 2 diabetes' Diabetologia, vol. 61, pp. 607-615.
https://doi.org/10.1007/s00125-017-4519-5

Research output: Contribution To Journal



Bell, S, Soto-Pedre, E, Connelly, P, Livingstone, S & Pearson, E 2017,

'Clarifying the relationship between metformin, acute kidney injury and lactic acidosis' Nature Reviews Nephrology, vol. 14, 70.
https://doi.org/10.1038/nrneph.2017.172

Research output: Contribution To Journal



Dawed, AY, Ali, A, Zhou, K, Pearson, ER & Franks, PW 2017,

'Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes' Diabetologia, vol. 60, no. 11, pp. 2231-2239.
https://doi.org/10.1007/s00125-017-4404-2

Research output: Contribution To Journal



Soto-Pedre, E, Siddiqui, MK, Doney, AS, Palmer, CNA, Pearson, ER & Leese, GP 2017,

'Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits: a Genetics of Diabetes Audit and Research Tayside study' Pharmacogenetics and Genomics, vol. 27, no. 10, pp. 356-362.
https://doi.org/10.1097/FPC.0000000000000299

Research output: Contribution To Journal



Eibich, P, Green, A, Hattersley, AT, Jennison, C, Lonergan, M, Pearson, ER & Gray, AM 2017,

'Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study' Diabetes Therapy, vol. 8, no. 5, pp. 1031-1045.
https://doi.org/10.1007/s13300-017-0296-x

Research output: Contribution To Journal



Rena, G, Hardie, DG & Pearson, ER 2017,

'The mechanisms of action of metformin' Diabetologia, vol. 60, no. 9, pp. 1577-1585.
https://doi.org/10.1007/s00125-017-4342-z

Research output: Contribution To Journal



Dujic, T, Zhou, K, Donnelly, LA, Leese, G, Palmer, CNA & Pearson, ER 2017,

'Interaction between variants in the CYP2C9 and POR genes and the risk of sulfonylurea-induced hypoglycaemia: A Go DARTS Study' Diabetes, Obesity & Metabolism.
https://doi.org/10.1111/dom.13046

Research output: Contribution To Journal



Shields, BM, Shepherd, MH, Hudson, MM, Mc Donald, TJ, Colclough, K, Peters, J, Knight, B, Hyde, C, Ellard, S, Pearson, ER, Hattersley, AT & on behalf of the UNITED study team 2017,

'Population-Based Assessment of a Biomarker-Based Screening Pathway to Aid Diagnosis of Monogenic Diabetes in Young-Onset Patients' Diabetes Care, vol. 40, no. 8, pp. 1017-1025.
https://doi.org/10.2337/dc17-0224

Research output: Contribution To Journal



Siddiqui, MK, Veluchamy, A, Maroteau, C, Tavendale, R, Carr, F, Pearson, E, Colhoun, H, Morris, AD, George, J, Doney, A, Pirmohamed, M, Alfirevic, A, Wadelius, M, Maitland-van der Zee, AH, Ridker, PM, Chasman, DI, Palmer, CNA & on behalf of the PREDICTION-ADR Consortium 2017,

'CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia' Circulation: Cardiovascular Genetics, vol. 10, no. 4, e001737 .
https://doi.org/10.1161/CIRCGENETICS.117.001737

Research output: Contribution To Journal



Wood, AR, Jonsson, A, Jackson, AU, Wang, N, van Leewen, N, Palmer, ND, Kobes, S, Deelen, J, Boquete-Vilarino, L, Paananen, J, Stančáková, A, Boomsma, DI, de Geus, EJC, Eekhoff, EMW, Fritsche, A, Kramer, MHH, Nijpels, G, Simonis-Bik, AMC, van Haeften, TW, Mahajan, A, Boehnke, M, Bergman, RN, Tuomilehto, J, Collins, FS, Mohlke, KL, Banasik, K, Groves, CJ, Mc Carthy, MI, Pearson, ER, Natali, A, Mari, A, Buchanan, TA, Taylor, KD, Xiang, AH, Gjesing, AP, Grarup, N, Eiberg, H, Pedersen, O, Chen, Y-D, Laakso, M, Norris, JM, Smith, U, Wagenknecht, LE, Baier, L, Bowden, DW, Hansen, T, Walker, M, Watanabe, RM, 't Hart, LM, Hanson, RL & Frayling, TM 2017,

'A Genome-Wide Association Study of IVGTT-Based Measures of First Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants' Diabetes, vol. 66, no. 8, pp. 2296-2309.
https://doi.org/10.2337/db16-1452

Research output: Contribution To Journal



Connelly, PJ, Lonergan, M, Soto-Pedre, E, Donnelly, L, Zhou, K & Pearson, ER 2017,

'Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: A Go Darts study' Diabetes, Obesity & Metabolism, vol. 19, no. 11, pp. 1579-1586.
https://doi.org/10.1111/dom.12978

Research output: Contribution To Journal



Yaghootkar, H, Bancks, MP, Jones, SE, Mc Daid, A, Beaumont, R, Donnelly, L, Wood, AR, Campbell, A, Tyrrell, J, Hocking, LJ, Tuke, MA, Ruth, KS, Pearson, ER, Murray, A, Freathy, RM, Munroe, PB, Hayward, C, Palmer, C, Weedon, MN, Pankow, JS, Frayling, TM & Kutalik, Z 2017,

'Quantifying the extent to which index event biases influence large genetic association studies' Human Molecular Genetics, vol. 26, no. 5, pp. 1018-1030.
https://doi.org/10.1093/hmg/ddw433

Research output: Contribution To Journal



Dujic, T, Zhou, K, Yee, SW, van Leeuwen, N, de Keyser, CE, Javorský, M, Goswami, S, Zaharenko, L, Christiansen, MMH, Out, M, Tavendale, R, Kubo, M, Hedderson, MM, van der Heijden, AA, Klimčáková, L, Pirags, V, Kooy, A, Brøsen, K, Klovins, J, Semiz, S, Tkáč, I, Stricker, BH, Palmer, CNA, 't Hart, LM, Giacomini, KM & Pearson, ER 2017,

'Variants in pharmacokinetic transporters and glycemic response to metformin: A metgen meta-analysis' Clinical Pharmacology & Therapeutics, vol. 101, no. 6, pp. 763-772.
https://doi.org/10.1002/cpt.567

Research output: Contribution To Journal



Preiss, D, Dawed, A, Welsh, P, Heggie, A, Jones, AG, Dekker, J, Koivula, R, Hansen, TH, The DIRECT consortium, Stewart, C, Holman, RR, Franks, PW, Walker, M, Pearson, ER & Sattar, N 2017,

'The sustained influence of metformin therapy on circulating GLP-1 levels in individuals with and without type 2 diabetes' Diabetes, Obesity & Metabolism, vol. 19, no. 3, pp. 356-363.
https://doi.org/10.1111/dom.12826

Research output: Contribution To Journal



Rauh, SP, Heymans, MW, Koopman, ADM, Nijpels, G, Stehouwer, CD, Thorand, B, Rathmann, W, Meisinger, C, Peters, A, de Las Heras Gala, T, Glümer, C, Pedersen, O, Cederberg, H, Kuusisto, J, Laakso, M, Pearson, ER, Franks, PW, Rutters, F & Dekker, JM 2017,

'Predicting glycated hemoglobin levels in the non-diabetic general population: Development and validation of the DIRECT-DETECT prediction model - a DIRECT study' PLo S ONE, vol. 12, no. 2, e0171816, pp. 1-13.
https://doi.org/10.1371/journal.pone.0171816

Research output: Contribution To Journal



Lonergan, M, Senn, SJ, Mc Namee, C, Daly, AK, Sutton, R, Hattersley, A, Pearson, E & Pirmohamed, M 2017,

'Defining drug response for stratified medicine' Drug Discovery Today, vol. 22, no. 1, pp. 173-179.
https://doi.org/10.1016/j.drudis.2016.10.016

Research output: Contribution To Journal



Atabaki-Pasdar, N, Ohlsson, M, Shungin, D, Kurbasic, A, Ingelsson, E, Pearson, ER, Ali, A & Franks, PW 2016,

'Statistical power considerations in genotype-based recall randomized controlled trials' Scientific Reports, vol. 6, 37307, pp. 1-11.
https://doi.org/10.1038/srep37307

Research output: Contribution To Journal



Dujic, T, Zhou, K, Tavendale, R, Palmer, C & Pearson, E 2016,

'Effect of Serotonin Transporter 5HTTLPR Polymorphism on Gastrointestinal Intolerance to Metformin: A Go DARTS Study' Diabetes Care, vol. 39, no. 11, pp. 1896-1901.
https://doi.org/10.2337/dc16-0706

Research output: Contribution To Journal



Dawed, AY, Donnelly, L, Tavendale, R, Carr, F, Leese, G, Palmer, CNA, Pearson, E & Zhou, K 2016,

'CYP2C8 and SLCO1B1 variants and therapeutic response to thiazolidinediones in patients with type 2 diabetes.' Diabetes Care, vol. 39, no. 11, pp. 1902-1908.
https://doi.org/10.2337/dc15-2464

Research output: Contribution To Journal



Shepherd, M, Shields, B, Hammersley, S, Hudson, M, Mc Donald, TJ, Colclough, K, Oram, RA, Knight, B, Hyde, C, Cox, J, Mallam, K, Moudiotis, C, Smith, R, Fraser, B, Robertson, S, Greene, S, Ellard, S, Pearson, ER, Hattersley, AT & on behalf of the UNITED Team 2016,

'Systematic population screening, using biomarkers and genetic testing, identifies 2.5% of the U.K. pediatric diabetes population with monogenic diabetes' Diabetes Care, vol. 39, no. 11, pp. 1879-1888.
https://doi.org/10.2337/dc16-0645

Research output: Contribution To Journal



Yew, TW, Mc Creight, L, Colclough, K, Ellard, S & Pearson, ER 2016,

't RNA methyltransferase homologue gene TRMT10A mutation in young adult-onset diabetes with intellectual disability, microcephaly and epilepsy' Diabetic Medicine, vol. 33, no. 9, pp. e21-e25.
https://doi.org/10.1111/dme.13024

Research output: Contribution To Journal



Zhou, K, Yee, SW, Seiser, EL, van Leeuwen, N, Tavendale, R, Bennett, AJ, Groves, CJ, Coleman, RL, van der Heijden, AA, Beulens, JW, de Keyser, CE, Zaharenko, L, Rotroff, DM, Out, M, Jablonski, KA, Chen, L, Javorský, M, Židzik, J, Levin, AM, Williams, LK, Dujic, T, Semiz, S, Kubo, M, Chien, H-C, Maeda, S, Witte, JS, Wu, L, Tkáč, I, Kooy, A, van Schaik, RHN, Stehouwer, CDA, Logie, L, Sutherland, C, Klovins, J, Pirags, V, Hofman, A, Stricker, BH, Motsinger-Reif, AA, Wagner, MJ, Innocenti, F, Hart, LM, Holman, RR, Mc Carthy, MI, Hedderson, MM, Palmer, CNA, Florez, JC, Giacomini, KM, Pearson, ER & Met Gen Investigators 2016,

'Variation in the Glucose Transporter gene SLC2A2 is associated with glycaemic response to metformin' Nature Genetics, vol. 48, no. 9, pp. 1055-1059.
https://doi.org/10.1038/ng.3632

Research output: Contribution To Journal



Yaghootkar, H, Lotta, LA, Tyrrell, J, Smit, RAJ, Jones, SE, Donnelly, L, Beaumont, R, Campbell, A, Tuke, MA, Hayward, C, Ruth, KS, Padmanabhan, S, Jukema, JW, Palmer, CC, Hattersley, A, Freathy, RM, Langenberg, C, Wareham, NJ, Wood, AR, Murray, A, Weedon, MN, Sattar, N, Pearson, E, Scott, RA & Frayling, TM 2016,

'Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease' Diabetes, vol. 65, no. 8, pp. 2448-2460.
https://doi.org/10.2337/db15-1671

Research output: Contribution To Journal



Singh, JSS, Fathi, A, Vickneson, K, Mordi, I, Mohan, M, Houston, JG, Pearson, ER, Struthers, AD & Lang, CC 2016,

'Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design' Cardiovascular Diabetology, vol. 15, 97, pp. 1-11.
https://doi.org/10.1186/s12933-016-0419-0

Research output: Contribution To Journal



Pearson, ER 2016,

'Personalized medicine in diabetes: The role of 'omics' and biomarkers' Diabetic Medicine, vol. 33, no. 6, pp. 712-717.
https://doi.org/10.1111/dme.13075

Research output: Contribution To Journal



Zhou, K, Pedersen, HK, Dawed, AY & Pearson, ER 2016,

'Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery' Nature Reviews Endocrinology, vol. 12, no. 6, pp. 337-346.
https://doi.org/10.1038/nrendo.2016.51

Research output: Contribution To Journal



Angwin, C, Pearson, E & Hattersley, A 2016,

'Crossover studies can help the individualisation of care in type 2 diabetes: the MASTERMIND approach' Practical Diabetes, vol. 33, no. 4, pp. 115-117.
https://doi.org/10.1002/pdi.2015

Research output: Contribution To Journal



Kovacs, P & Pearson, E 2016,

Pharmacogenetics of sulfonylureas. in JC Florez (ed.), The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation. pp. 483-497.
https://doi.org/10.1007/978-3-319-01574-3_23

Research output: Contribution To Book Anthology



Dawed, AY, Zhou, K & Pearson, ER 2016,

'Pharmacogenetics in type 2 diabetes: Influence on response to oral hypoglycemic agents' Pharmacogenomics and Personalized Medicine, vol. 9, pp. 17-29.
https://doi.org/10.2147/PGPM.S84854

Research output: Contribution To Journal



Jones, AG, Lonergan, M, Henley, WE, Pearson, ER, Hattersley, AT & Shields, BM 2016,

'Should studies of diabetes treatment stratification correct for baseline Hb A1c?' PLo S ONE, vol. 11, no. 4, e0152428.
https://doi.org/10.1371/journal.pone.0152428

Research output: Contribution To Journal



Dujic, T, Causevic, A, Bego, T, Malenica, M, Velija-Asimi, Z, Pearson, ER & Semiz, S 2016,

'Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes' Diabetic Medicine, vol. 33, no. 4, 13040, pp. 511-514.
https://doi.org/10.1111/dme.13040

Research output: Contribution To Journal



Connelly, PJ, Smith, N, Chadwick, R, Exley, AR, Shneerson, JM & Pearson, ER 2016,

'Recessive mutations in the cancer gene Ataxia Telangiectasia Mutated (ATM), at a locus previously associated with metformin response, cause dysglycaemia and insulin resistance' Diabetic Medicine, vol. 33, no. 3, pp. 371-375.
https://doi.org/10.1111/dme.13037

Research output: Contribution To Journal



Mc Creight, LJ, Bailey, CJ & Pearson, ER 2016,

'Metformin and the gastrointestinal tract' Diabetologia, vol. 59, no. 3, pp. 426-435.
https://doi.org/10.1007/s00125-015-3844-9

Research output: Contribution To Journal



Farmer, AJ, Rodgers, LR, Lonergan, M, Shields, B, Weedon, MN, Donnelly, L, Holman, RR, Pearson, ER & Hattersley, AT 2016,

'Adherence to oral glucose-lowering therapies and associations with 1-year Hb A1c: A retrospective cohort analysis in a large primary care database' Diabetes Care, vol. 39, no. 2, pp. 258-263.
https://doi.org/10.2337/dc15-1194

Research output: Contribution To Journal



Pearson, ER 2015,

'Dissecting the etiology of type 2 diabetes in the Pima Indian population' Diabetes, vol. 64, no. 12, pp. 3993-3995.
https://doi.org/10.2337/dbi15-0016

Research output: Contribution To Journal



Siddiqui, MK, Veluchamy, A, Tavendale, R, Carr, F, Maroteau, C, Pearson, ER, Looker, HM, Morris, AD, Dow, E, George, J, Doney, A & Palmer, CNA 2015,

'A common missense variant of LILRB5 is associated with statin intolerance: A Go DARTS study' 65th American Society of Human Genetics Annual Meeting, Baltimore, United States, 6/10/15 - 10/10/15, .

Research output: Contribution To Conference



Dujic, T, Zhou, K, Donnelly, LA, Tavendale, R, Palmer, CNA & Pearson, ER 2015,

'Association of organic cation transporter 1 with intolerance to metformin in Type 2 diabetes: a Go DARTS study' Diabetes, vol. 64, no. 5, pp. 1786-1793.
https://doi.org/10.2337/db14-1388

Research output: Contribution To Journal



Oram, RA, Mc Donald, TJ, Shields, BM, Hudson, MM, Shepherd, MH, Hammersley, S, Pearson, ER, Hattersley, AT & on behalf of the UNITED Team 2015,

'Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors' Diabetes Care, vol. 38, no. 2, pp. 323-328.
https://doi.org/10.2337/dc14-0871

Research output: Contribution To Journal



Koivula, RW, Heggie, A, Barnett, A, Cederberg, H, Hansen, TH, Koopman, AD, Ridderstråle, M, Rutters, F, Vestergaard, H, Gupta, R, Herrgård, S, Heymans, MW, Perry, MH, Rauh, S, Siloaho, M, Teare, HJA, Thorand, B, Bell, J, Brunak, S, Frost, G, Jablonka, B, Mari, A, Mc Donald, TJ, Dekker, JM, Hansen, T, Hattersley, A, Laakso, M, Pedersen, O, Koivisto, V, Ruetten, H, Walker, M, Pearson, E, Franks, PW & DIRECT Consortium 2014,

'Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium' Diabetologia, vol. 57, no. 6, pp. 1132-1142.
https://doi.org/10.1007/s00125-014-3216-x

Research output: Contribution To Journal



Zhou, K, Donnelly, L, Yang, J, Li, M, Deshmukh, H, Van Zuydam, N, Ahlqvist, E, Spencer, CC, Groop, L, Morris, AD, Colhoun, HM, Sham, PC, Mc Carthy, MI, Palmer, CNA & Pearson, ER 2014,

'Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis' The Lancet: Diabetes and Endocrinology, vol. 2, no. 6, pp. 481-487.
https://doi.org/10.1016/S2213-8587(14)70050-6

Research output: Contribution To Journal



Pearson, E 2014,

'RD Lawrence Lecture 2013: Stratified approaches to the management of diabetes' Diabetic Medicine, vol. 31, no. 4, pp. 393-398.
https://doi.org/10.1111/dme.12391

Research output: Contribution To Journal



Pearson, E 2014,

'Zinc transport and diabetes risk' Nature Genetics, vol. 46, no. 4, pp. 323-4.
https://doi.org/10.1038/ng.2934

Research output: Contribution To Journal



Zhou, K, Donnelly, LA, Morris, AD, Franks, PW, Jennison, C, Palmer, CNA & Pearson, ER 2014,

'Clinical and genetic determinants of progression of type 2 diabetes: A DIRECT Study' Diabetes Care, vol. 37, no. 3, pp. 718-724.
https://doi.org/10.2337/dc13-1995

Research output: Contribution To Journal



Pearson, ER & Florez, JC 2014,

'Genetics of Drug Response in Diabetes' Frontiers in Diabetes, vol. 23, pp. 158-172.
https://doi.org/10.1159/000362475

Research output: Contribution To Journal



Liu, Y, Wang, M, Morris, AD, Doney, ASF, Leese, GP, Pearson, ER & Palmer, CNA 2013,

'Glycemic exposure and blood pressure influencing progression and remission of diabetic retinopathy: a longitudinal cohort study in Go DARTS' Diabetes Care, vol. 36, no. 12, pp. 3979-3984.
https://doi.org/10.2337/dc12-2392

Research output: Contribution To Journal



Gardiner, A, George, PS, Pearson, E & Mc Crimmon, RJ 2013,

'An interesting case of new-onset ketosis-prone diabetes in a Scottish teaching hospital' British Journal of Diabetes and Vascular Disease, vol. 13, no. 5-6, pp. 265-268.
https://doi.org/10.1177/1474651413503891

Research output: Contribution To Journal



Rena, G, Pearson, ER & Sakamoto, K 2013,

'Molecular mechanism of action of metformin: old or new insights?' Diabetologia, vol. 56, no. 9, pp. 1898-1906.
https://doi.org/10.1007/s00125-013-2991-0

Research output: Contribution To Journal



Franks, PW, Pearson, E & Florez, JC 2013,

'Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects' Diabetes Care, vol. 36, no. 5, pp. 1413-1421.
https://doi.org/10.2337/dc12-2211

Research output: Contribution To Journal



Vella, S, Donnelly, L, Lang, CC, Pearson, ER & Petrie, JR 2013,

'Is thiazolidinedione treatment an important cause of oedema?' Diabetic Medicine, vol. 30, no. Suppl. 1, P562, pp. 197-197.
https://doi.org/10.1111/dme.12091_2

Research output: Contribution To Journal



Donnelly, LA, Zhou, K, Palmer, CNA, Doney, ASF, Morris, AD & Pearson, ER 2013,

'Clinical predictors of rate of progression of type 2 diabetes: an extreme case-control study' Diabetic Medicine, vol. 30, no. Suppl. 1, P213, pp. 94-94.
https://doi.org/10.1111/dme.12091_2

Research output: Contribution To Journal



Connelly, PJ, Gellatly, E, Bell, L, Shepherd, M, Hattersley, AT & Pearson, E 2013,

'Measuring endogenous insulin secretion in type 1 diabetes is life changing' Diabetic Medicine, vol. 30, no. Suppl. 1, P215, pp. 94-95.
https://doi.org/10.1111/dme.12091_2

Research output: Contribution To Journal



Zhou, K, Bennett, A, Coleman, R, Groves, R, Holman, R, Mc Carthy, M, Palmer, C & Pearson, E 2013,

'Metformin pharmacogenetics and SLC2A2: genome-wide association study and 2-stage replication in Go DARTS and UKPDS' Diabetic Medicine, vol. 30, no. Suppl. 1, P79, pp. 52-52.
https://doi.org/10.1111/dme.12091_1

Research output: Contribution To Journal



Zhou, K & Pearson, ER 2013,

'Insights from genome-wide association studies of drug response' Annual Review of Pharmacology and Toxicology, vol. 53, pp. 299-310.
https://doi.org/10.1146/annurev-pharmtox-011112-140237

Research output: Contribution To Journal



Vella, S, Donnelly, L, Lang, CC, Pearson, ER & Petrie, JR 2013,

'Is thiazolidinedione treatment an important cause of oedema?' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .

Research output: Contribution To Conference



Donnelly, LA, Zhou, K, Palmer, CNA, Doney, ASF, Morris, AD & Pearson, ER 2013,

'Clinical predictors of rate of progression of type 2 diabetes: an extreme case-control study' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .

Research output: Contribution To Conference



Connelly, PJ, Gellatly, E, Bell, L, Shepherd, M, Hattersley, AT & Pearson, E 2013,

'Measuring endogenous insulin secretion in type 1 diabetes is life changing' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .

Research output: Contribution To Conference



Zhou, K, Bennett, A, Coleman, R, Groves, R, Holman, R, Mc Carthy, M, Palmer, C & Pearson, E 2013,

'Metformin pharmacogenetics and SLC2A2: genome-wide association study and 2-stage replication in Go DARTS and UKPDS' Diabetes UK Professional Conference 2013, Manchester, United Kingdom, 13/03/13 - 15/03/13, .

Research output: Contribution To Conference



Shepherd, M, Shields, BM, Pearson, E, Oram, R, Ellard, S, Hattersley, AT & UNITED Res Team 2013,

'The first prospective study of treatment change in transcription factor maturity onset diabetes of the young (MODY): impact on glycaemic control and quality of life' Diabetic Medicine, vol. 30, no. Supplement 1, A69 (P434), pp. 25.
https://doi.org/10.1111/dme.12090_14

Research output: Contribution To Journal



Sanders, T, Oram, RA, Shepherd, M, Pearson, E, Mac Donald, TJ, Ellard, S, Shields, BM, Hattersley, AT & UNITED Res Team 2013,

'Time to reconsider? Reassessment of diagnosis in long duration Type 1 diabetes with urinary C-peptide creatinine ratio and antibodies identifies people with alternate diagnoses' Diabetic Medicine, vol. 30, no. Supplement 1, A72 (P110), pp. 26-26.
https://doi.org/10.1111/dme.12090_14

Research output: Contribution To Journal



't Hart, LM, Fritsche, A, Nijpels, G, van Leeuwen, N, Donnelly, LA, Dekker, JM, Alssema, M, Fadista, J, Carlotti, F, Gjesing, AP, Palmer, CNA, van Haeften, TW, Herzberg-Schäfer, SA, Simonis-Bik, AMC, Houwing-Duistermaat, JJ, Helmer, Q, Deelen, J, Guigas, B, Hansen, T, Machicao, F, Willemsen, G, Heine, RJ, Kramer, MHH, Holst, JJ, de Koning, EJP, Häring, H-U, Pedersen, O, Groop, L, de Geus, EJC, Slagboom, PE, Boomsma, DI, Eekhoff, EMW, Pearson, ER & Diamant, M 2013,

'The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway' Diabetes.
https://doi.org/10.2337/db13-0227

Research output: Contribution To Journal



Donnelly, LA, van Zuydam, NR, Zhou, K, Tavendale, R, Carr, F, Maitland-van der Zee, AH, Leusink, M, de Boer, A, Doevendans, PA, Asselbergs, FW, Morris, AD, Pearson, ER, Klungel, OH, Doney, ASF & Palmer, CNA 2013,

'Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment' Pharmacogenetics and Genomics, vol. 23, no. 10, pp. 518-525.
https://doi.org/10.1097/FPC.0b013e3283642fd6

Research output: Contribution To Journal



Macfarlane, DP, O'Sullivan, EP, Dorman, S, Allison, J, Ellingford, A, Pearson, ER, Mires, GJ & Leese, GP 2013,

'The utility of retinal screening in gestational diabetes' Diabetic Medicine, vol. 30, no. 8, pp. 1009-1010.
https://doi.org/10.1111/dme.12152

Research output: Contribution To Journal



Becker, ML, Pearson, ER & Tkáč, I 2013,

'Pharmacogenetics of oral antidiabetic drugs' International Journal of Endocrinology, vol. 2013, 686315.
https://doi.org/10.1155/2013/686315

Research output: Contribution To Journal



Taal, HR, St Pourcain, B, Thiering, E, Das, S, Mook-Kanamori, DO, Warrington, NM, Kaakinen, M, Kreiner-Moller, E, Bradfield, JP, Freathy, RM, Geller, F, Guxens, M, Cousminer, DL, Kerkhof, M, Timpson, NJ, Ikram, MA, Beilin, LJ, Bonnelykke, K, Buxton, JL, Charoen, P, Chawes, BLK, Eriksson, J, Evans, DM, Hofman, A, Kemp, JP, Kim, CE, Klopp, N, Lahti, J, Lye, SJ, Mc Mahon, G, Mentch, FD, Mueller-Nurasyid, M, O'Reilly, PF, Prokopenko, I, Rivadeneira, F, Steegers, EAP, Sunyer, J, Tiesler, C, Yaghootkar, H, Breteler, MMB, Debette, S, Fornage, M, Gudnason, V, Launer, LJ, van der Lugt, A, Mosley, TH, Seshadri, S, Smith, AV, Vernooij, MW, Pearson, ER & Early Genetics Lifecourse Epidemio, Early Growth Genetics EGG Consorti, Cohorts Heart Aging Res Genetic Ep 2012,

'Common variants at 12q15 and 12q24 are associated with infant head circumference' Nature Genetics, vol. 44, no. 5, pp. 532-538.
https://doi.org/10.1038/ng.2238

Research output: Contribution To Journal



Ikram, MA, Fornage, M, Smith, AV, Seshadri, S, Schmidt, R, Debette, S, Vrooman, HA, Sigurdsson, S, Ropele, S, Taal, HR, Mook-Kanamori, DO, Coker, LH, Longstreth, WT, Niessen, WJ, De Stefano, AL, Beiser, A, Zijdenbos, AP, Struchalin, M, Jack, CR, Rivadeneira, F, Uitterlinden, AG, Knopman, DS, Hartikainen, A-L, Pennell, CE, Thiering, E, Steegers, EAP, Hakonarson, H, Heinrich, J, Palmer, LJ, Jarvelin, M-R, Mc Carthy, MI, Grant, SFA, St Pourcain, B, Timpson, NJ, Smith, GD, Sovio, U, Nalls, MA, Au, R, Hofman, A, Gudnason, H, van der Lugt, A, Harris, TB, Meeks, WM, Vernooij, MW, van Buchem, MA, Catellier, D, Jaddoe, VWV, Gudnason, V, Windham, BG, Wolf, PA, van Duijn, CM, Mosley, TH, Schmidt, H, Launer, LJ, Breteler, MMB, De Carli, C, Adair, LS, Ang, W, Atalay, M, van Beijsterveldt, T, Bergen, N, Benke, K, Berry, D, Coin, L, Davis, OSP, Elliott, P, Flexeder, C, Frayling, T, Gaillard, R, Groen-Blokhuis, M, Goh, L-K, Haworth, CMA, Hadley, D, Hedebrand, J, Hinney, A, Hirschhorn, JN, Holloway, JW, Holst, C, Hottenga, JJ, Horikoshi, M, Huikari, V, Hypponen, E, Kilpelainen, TO, Kirin, M, Kowgier, M, Lakka, H-M, Lange, LA, Lawlor, DA, Lehtimaki, T, Lewin, A, Lindgren, C, Lindi, V, Maggi, R, Marsh, J, Middeldorp, C, Millwood, I, Murray, JC, Nivard, M, Nohr, EA, Ntalla, I, Oken, E, Panoutsopoulou, K, Pararajasingham, J, Rodriguez, A, Salem, RM, Sebert, S, Siitonen, N, Strachan, DP, Teo, Y-Y, Valcarcel, B, Willemsen, G, Zeggini, E, Boomsma, DI, Cooper, C, Gillman, M, Hocher, B, Lakka, TA, Mohlke, KL, Dedoussis, GV, Ong, KK, Pearson, ER, Price, TS, Power, C, Raitakari, OT, Saw, S-M, Scherag, A, Simell, O, Sorensen, TIA & Wilson, JF 2012,

'Common variants at 6q22 and 17q21 are associated with intracranial volume' Nature Genetics, vol. 44, no. 5, pp. 539-544.
https://doi.org/10.1038/ng.2245

Research output: Contribution To Journal



Zhou, K, Bellenguez, C, Sutherland, C, Hardie, G, Palmer, C, Donnelly, P & Pearson, E 2012,

'The role of ATM in response to metformin treatment and activation of AMPK reply' Nature Genetics, vol. 44, no. 4, pp. 361-362.
https://doi.org/10.1038/ng.2234

Research output: Contribution To Journal



van Leeuwen, N, Nijpels, G, Becker, ML, Deshmukh, H, Zhou, K, Stricker, BHC, Uitterlinden, AG, Hofman, A, van 't Riet, E, Palmer, CNA, Guigas, B, Slagboom, PE, Durrington, P, Calle, RA, Neil, A, Hitman, G, Livingstone, SJ, Colhoun, H, Holman, RR, Mc Carthy, MI, Dekker, JM, 't Hart, LM & Pearson, E 2012,

'A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts' Diabetologia, vol. 55, no. 7, pp. 1971-1977.
https://doi.org/10.1007/s00125-012-2537-x

Research output: Contribution To Journal



Mc Donald, TJ, Mc Eneny, J, Pearson, ER, Thanabalasingham, G, Szopa, M, Shields, BM, Ellard, S, Owen, KR, Malecki, MT, Hattersley, AT & Young, IS 2012,

'Lipoprotein composition in HNF1A-MODY: differentiating between HNF1A-MODY and type 2 diabetes' Clinica Chimica Acta, vol. 413, no. 9-10, pp. 927-932.
https://doi.org/10.1016/j.cca.2012.02.005

Research output: Contribution To Journal



Palmer, CNA, Maglio, C, Pirazzi, C, Burza, MA, Adiels, M, Burch, L, Donnelly, LA, Colhoun, H, Doney, AS, Dillon, JF, Pearson, ER, Mc Carthy, M, Hattersley, AT, Frayling, T, Morris, AD, Peltonen, M, Svensson, P-A, Jacobson, P, Borén, J, Sjöström, L, Carlsson, LMS & Romeo, S 2012,

'Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant' PLo S ONE, vol. 7, no. 6, e39362.
https://doi.org/10.1371/journal.pone.0039362

Research output: Contribution To Journal



George, PS, Pearson, ER & Witham, MD 2012,

'Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis' Diabetic Medicine, vol. 29, no. 8, pp. e142-e150.
https://doi.org/10.1111/j.1464-5491.2012.03672.x

Research output: Contribution To Journal



Colhoun, HM, Livingstone, SJ, Looker, HC, Morris, AD, Wild, SH, Lindsay, RS, Reed, C, Donnan, PT, Guthrie, B, Leese, GP, Mc Knight, J, Pearson, DW, Pearson, E, Petrie, JR, Philip, S, Sattar, N, Sullivan, FM & Mc Keigue, P 2012,

'Hospitalised hip fracture risk with rosiglitazone and pioglitazone use compared with other glucose-lowering drugs' Diabetologia, vol. 55, no. 11, pp. 2929-2937.
https://doi.org/10.1007/s00125-012-2668-0

Research output: Contribution To Journal



Pearson, ER 2012,

'Treating type 2 diabetes in youth: a depressing picture' Journal of the Royal College of Physicians of Edinburgh, vol. 42, no. 3, pp. 228.
https://doi.org/10.4997/JRCPE.2012.309

Research output: Contribution To Journal



Zhou, K & Pearson, ER 2011,

'Determinants of glycemic response to metformin: do the organic cation transporters hold the key?' Pharmacogenomics Journal, vol. 12, no. 5, pp. 707-708.

Research output: Contribution To Journal



Zhou, K & Pearson, ER 2011,

'OCT3 is a major determinant of metformin effect in skeletal muscle' Pharmacogenomics Journal, vol. 12, no. 5, pp. 708-709.

Research output: Contribution To Journal



Zhou, K & Pearson, ER 2011,

'More OCT1 variants in the Asian population' Pharmacogenomics Journal, vol. 12, no. 5, pp. 709-709.

Research output: Contribution To Journal



Zhou, K & Pearson, ER 2011,

'Casting the net wider: a comprehensive candidate gene study' Pharmacogenomics Journal, vol. 12, no. 5, pp. 710-711.

Research output: Contribution To Journal



Zhou, K & Pearson, ER 2011,

'Identifying a new role for OCT1 in pharmacogenetics' Pharmacogenomics Journal, vol. 12, no. 5, pp. 711-711.

Research output: Contribution To Journal



Petrie, JR, Pearson, ER & Sutherland, C 2011,

'Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology' Biochemical Pharmacology, vol. 81, no. 4, pp. 471-477.
https://doi.org/10.1016/j.bcp.2010.11.010

Research output: Contribution To Journal



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Activities

The Croom Lecture - Royal College of Physicians of Edinburgh

Role: Speaker
Activity: Invited talk

  2006

ESPT meeting Catania, Sicilly

Role: Speaker
Activity: Invited talk

4 10 2017

EASD Genetics Study Group, Leiden

Role: Speaker
Activity: Invited talk

12 5 2017