Bio

Research interests

Synaptic alterations feature in many neurological conditions and this has been a central focus throughout my postgraduate research. I spent my first postdoctoral position in the lab or Dr. Istvan Katona in Budapest, assessing the nanoscale distribution of synaptic proteins in a mouse model of Fragile X Syndrome, funded by an EMBO long-term fellowship. With the aim of building upon my technical expertise, I moved to the lab of Dr. Tara Spires-Jones at the University of Edinburgh in 2014 and in 2016 was awarded a 3yr project grant from MND Scotland. The focus of this project is to characterise the synaptic profile of the ALS brain. To do this, I apply high-resolution imaging techniques such as electron microscopy and  array tomography, to examine the structure and function of synapses in human brain. During my time in Edinburgh I helped build the world’s first brain bank of human ALS tissue prepared for the array tomography technique.

In May 2019 I moved to the University of Dundee to establish my own group and continue my research on synaptic pathology in health and disease. My interests are highly interdisciplinary, involving collaboration with local and international colleagues in psychology, neuropathology, neuroimaging, and genetics.

Publications

Glial contribution to excitatory and inhibitory synapse loss in neurodegeneration
2/2019, Frontiers in Cellular Neuroscience
Research Output: Contribution To Journal > Review article

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis
2/2019, Nature Reviews Neuroscience
Research Output: Contribution To Journal > Review article

Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer’s disease
9/2018, Acta Neuropathologica
Research Output: Contribution To Journal > Article

FENS-Kavli winter symposium : addressing the cellular phase of dementia - visions of the UK Dementia Research Institute
7/2018, European Journal of Neuroscience
Research Output: Contribution To Journal > Article

Modeling Alzheimer’s disease brains in Vitro
6/2018, Nature Neuroscience
Research Output: Contribution To Journal > Article

Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis
2/2018, Acta Neuropathologica
Research Output: Contribution To Journal > Article

Synaptic phosphorylated α-synuclein in dementia with Lewy bodies
11/2017, Brain
Research Output: Contribution To Journal > Article

Assessing amyloid-β, tau, and glial features in Lothian Birth Cohort 1936 participants post-mortem
10/2017, Science Matters
Research Output: Contribution To Journal > Article

Big conductance calcium-activated potassium channel openers control spasticity without sedation
8/2017, British Journal of Pharmacology
Research Output: Contribution To Journal > Article

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss
7/2017, Neuron
Research Output: Contribution To Journal > Article

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Press

New dementia buddy scheme established in Edinburgh by Dr. Chris Henstridge

Christopher Henstridge

29/12/18

1 item of Media coverage

Press/Media: Other



Christopher Henstridge discusses similarities between motor neuron disease and Alzheimer’s

Christopher Henstridge

23/12/17

2 items of Media coverage

Press/Media: Research



Dr Chris Henstridge discusses valuable ageing research based on Lothian Birth Cohort

Christopher Henstridge

28/10/15

1 item of Media coverage

Press/Media: Research



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Activities

Scottish Crucible

Christopher Henstridge (Participant)
May 2018Jun 2018

Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

Activity Type: Attendance

STEM for Britain

Christopher Henstridge (Participant)
9 Mar 2015

Activity: Participating in or organising an event typesFestival/Exhibition

Activity Type: Attendance

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