Douglas Steele

+44 (0)1382 496233
Deputy Head of Division - Imaging Science and Technology & Professor of Neuroimaging & Consultant Psychiatrist

Bio

Research

Before medicine I studied for a PhD in computational physics at Glasgow University, then worked as an NHS Medical Physicist for 3 years and Software Engineer in industry for 1 year.  I returned to university and after training in general medicine and psychiatry at Edinburgh University for 10 years, became Clincial Lecturer and Honorary SpR in Psychiatry at Edinburgh University and NHS Lothian, for a further 3 years.  In 2004 I moved to become Clinical Senior Lecturer in Psychiatry and Honorary Consultant Psychiatrist at Aberdeen University and NHS Grampian, before again moving in 2009 to become Clinical Professor in Neuroimaging and Honorary Consultant Psychiatrist at Dundee University and NHS Tayside.  I am Deputy Head of Division, Imaging Science and Technology, Medical School, and Co-Director, Clinical Research Imaging Facility, Ninewells Hospital, Dundee.

My main clinical and academic interests are psychiatry, neurology and its overlap neuropsychiatry, linked to neuroimaging and machine learning. I have a particular interest in mood disorder.  Two main areas:

i) Machine learning for individual patient predictions – diagnostic and prognostic.  Initial work focused on proof of concept studies using research data, now focused on application to routinely acquired NHS data, with a particular emphasis on fully integrating the techniques into routine clinical practice.  Recent success in obtaining MRC Programme Grant funding.

ii) Mechanisms research, which includes computational modelling of behaviour and brain function (model-based fMRI, forward translation), neurosurgical studies of causal therapeutic interventions for brain disorders and back translation (from functional brain imaging studies on patients to animals) for drug discovery.

 Selected Publications:

Steele, J.D., Paulus, M. (2019) “Pragmatic Neuroscience for Clinical Psychiatry”, British Journal of Psychiatry (in press)

Geugies, H., Mocking, R., Figueroa, C., Groot, P., Marsman, J., Servaas, M., Steele, J.D., Schene, A., Rhue, H (2019) “‘Impaired Reward-Related Learning Signals in Remitted Unmedicated Patients with Recurrent Depression” Brain (in press)

Queirazza, F., Fouragnan, E., Steele, J.D., Cavanagh, J., Philiastides, M. (2019) “Neural correlates of weighted reward prediction error during reinforcement learning classify response to Cognitive Behavioural Therapy in depression” Science Advances (in press)

Tolomeo, S., Christmas, D., Jentzsch, I., Johnston, B., Sprenglemeyer, R., Matthews, K., Steele, J.D. (2016) “A Causal Role for the Anterior Mid-Cingulate Cortex in Negative Affect and Cognitive Control”  Brain 139(Pt 6) 1844-54

Johnston, B.A.., Tolomeo, S, Gradin, V., Christmas, D., Matthews, K., Steele J.D. (2015) “Failure of Hippocampal Deactivation during Loss Events in Treatment-Resistant Depression” Brain 138(9) 2766-76

Gradin V., Baldacchino A., Balfour D., Matthews K, Steele J.D. (2014) “Abnormal Brain Activity during a Reward and Loss Task in Opiate Dependent Patients receiving Methadone Maintenance Therapy” Neuropsychopharmacology 39(4):885-94

Mwangi, B., Ebmeier K.P., Matthews, K.M., Steele, J.D. (2012) "Multicentre Diagnostic Classification of Individual Structural Neuroimaging Scans from Patients with Major Depressive Disorder", Brain 135(1) 1508-21

Perrin, J., Merz, S., Bennett, D.., Currie, J., Steele J.D., Reid I., Schwarzbauer C. (2012) "Electroconvulsive Therapy Reduces Frontal Connectivity in Severe Depression", Proc Natl Acad Sci USA 109(14) 5464-8

Gradin, V., Kumar, P., Waiter, G., Ahearn, T., Stickle, C., Milders, M., Reid, I., Hall, J., Steele, J.D. (2011) "Expected Value and Prediction Error Abnormalities in Depression and Schizophrenia", Brain 134(6) 1751-1764

Kumar P, Waiter G, Ahearn T, Milders M, Reid I, Steele J.D. (2008) “Abnormal temporal difference reward-learning signals in major depression” Brain, 131(8) 2084-2093

Rück C, Karlsson A, Steele J.D., Edman G, Meyerson B.A., Ericson K, Nyman H, Åsberg M, Svanborg P (2008) "Capsulotomy for Obsessive-Compulsive Disorder – long-term follow-up of 25 patients" JAMA Psychiatry, 65(8), 914-921

Steele J.D., Christmas D., Eljamel M.S., Matthews K. (2008) “Anterior cingulotomy for major depression: Clinical outcome and relationship to lesion characteristics” Biological Psychiatry, 63(7), 670-677

Steele J.D., Kumar P., Ebmeier, K.P. (2007) “Blunted response to feedback information in depressive illness”, Brain, 130 (9), 2367-74

Ebmeier K., Donaghey C., Steele J.D. (2006) “Recent Developments and Current Controversies in Depression”, Lancet, 367, 153-167

Steele J.D., Meyer M., Ebmeier K.P. (2004) “Neural Predictive Error Signal Correlates with Depressive Illness Severity in a Game Paradigm” NeuroImage, 23, 269-280

Teaching

For a number of years until recently I was Module Manager for Life Sciences and the Medical School, BSc and BMSc BS42017 and BM40019, “Psychiatric Disorders”, involving course design, teaching and examining of Psychiatric Neuroscience. In 2018 I broadened the course to become "Translational Psychiatry and Neurology"and stopped being Module Manager but continue to teach and examine on the course.  I teach and examine undergraduate medical students at Ninewells Hospital: OSCEs, small group tutorials, etc.

I am a supervisor for Life Sciences, Neuroscience BS40010 Honours Year projects, a supervisor for Biomedical Engineering ME52002 MSc projects and a supervisor for Dundee Clinical Academic Track (DCAT) Studentships.  I am a regular External PhD examiner to several Universities including Edinburgh, Aberdeen and Kings College London, and I am External Examiner for St Andrews University MSc in Digital Health.  I am PhD Lead for the Division of Imaging Science and Technology responsible for organising the Thesis Monitoring Committees and represent the Division on the Medical School Research Postgraduate Committee, plus I participate in one of the TMCs.

For a number of years I was External Examiner for undergraduate psychiatry at Edinburgh University MB ChB.     Previously I was also external examiner on Edinburgh University MSc Neuroimaging and external examiner for Edinburgh University MSc Neuroimaging for Research.  Previously I was an NHS supervisor for many NHS SpRs and SHOs in General Adult Psychiatry clinical training.

Biography

Before medicine: I began (’76) by studying for a BSc in Electrical & Electronic Engineering for 2 years at Paisley University doing various industrial placements, then switched to the last 3 years of honours Physics at Strathclyde University, graduating BSc (hons) Physics.  After this I did a PhD in Computational Physics at Glasgow University (Department of Physics & Institute of Physiology) using Electron Microscopy to target regions of animal & human pathology samples for spectroscopic chemical analyses.  The work was supported by a CASE studentship with sponsorship from Riker Laboratories Ltd, Loughborough, Leicestershire, a pharmaceutical company.  I spent a lot of time developing spectroscopy software which was later used by Glasgow University in part-payment for a new electron microscope.  After my PhD (’86) I worked for 3 years as an NHS Medical Physicist in Glasgow, then 1 year as a Software R&D Engineer at General Electric Ltd, Hertfordshire, programming a new Radiotherapy Treatment Planning system, an earlier version of which I had used as an NHS medical physicist in Belvidere Hospital, Glasgow. Near the end of this period I obtained Membership of the Institute of Physical Sciences in Medicine (MIPEM).

Medicine: I was accepted to study Medicine at Edinburgh University in ’89 and became interested in Psychiatric Neuroimaging during an undergraduate medical student placement at the MRC Brain Metabolism Unit, Royal Edinburgh Hospital, getting the first version of SPM working in Edinburgh in collaboration with Karl Friston.  After graduating MB ChB (’95) I trained in psychiatry based at the Royal Edinburgh Hospital, obtaining Royal College of Psychiatrists Membership (MRCPsych), an MD in Psychiatry & Neuroimaging (Edinburgh University), GMC registration as General Adult Psychiatrist, and have now worked clinically as an NHS Honorary Consultant Psychiatrist for ~15 years with a particular clinical interest in Neuropsychiatry.  My main research focus is quantitative clinical neuroimaging, particularly use of Machine Learning (also known as AI) for making novel clinically useful predictions, and computational modelling of behaviour & brain function to test hypotheses of abnormal pathophysiology.

Posts: NHS Medical Physicist, Glasgow (85-89); Software Engineer, IGE Medical Systems Ltd, Radlett Hertfordshire (89-90); House Officer, St John's and Kirkcaldy Hospitals (95-96); SHO Edinburgh Psychiatric Training Rotation (96-01); Wellcome Research Registrar, Edinburgh University and Royal Edinburgh Hospital (6 months 99); Lecturer and Honorary Specialist Registrar in Psychiatry, Edinburgh University and Royal Edinburgh Hospital (01-04); Senior Lecturer and Honorary Consultant Psychiatrist, Aberdeen University and Royal Cornhill Hospital (04-08); Professor of Neuroimaging and Honorary Consultant Psychiatrist, Dundee University and NHS Tayside/Fife (09-date), Honorary Professor, University of St Andrews (16-date)

 

Publications

Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression
8/2019, Brain
Research Output: Contribution To Journal > Article

Neural correlates of weighted reward prediction error during reinforcement learning classify response to Cognitive Behavioural Therapy in depression.
7/2019, Science Advances
Research Output: Contribution To Journal > Article

Pragmatic Neuroscience for Clinical Psychiatry
7/2019, British Journal of Psychiatry
Research Output: Contribution To Journal > Article

Maladaptive striatal plasticity and abnormal reward-learning in cervical dystonia
4/2019, European Journal of Neuroscience
Research Output: Contribution To Journal > Article

The neurobiology of personal control during reward learning and its relation to mood
2/2019, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Research Output: Contribution To Journal > Article

Chronic tobacco smoking and neuropsychological impairments : A systematic review and meta-analysis
1/2019, Neuroscience and Biobehavioral Reviews
Research Output: Contribution To Journal > Review article

Major Depression Impairs the Use of Reward Values for Decision-Making
9/2018, Scientific Reports
Research Output: Contribution To Journal > Article

Assessing ADHD symptoms in children and adults : Evaluating the role of objective measures
5/2018, Behavioral and Brain Functions
Research Output: Contribution To Journal > Article

Compulsivity in opioid dependence
2/2018, Progress in Neuro-Psychopharmacology and Biological Psychiatry
Research Output: Contribution To Journal > Article

Comprehensive review : Computational modelling of Schizophrenia
12/2017, Neuroscience and Biobehavioral Reviews
Research Output: Contribution To Journal > Review article

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