Daniel Morales

+44 (0)1382 383475
Discovery Fellow

Biography

Dr Morales is a General Practitioner conducting epidemiology and pharmacoepidemiology research. His interests include investigating the intended and adverse effects of drugs, medicines utilisation, risk communication and regulatory science. He also has direct experience of medicines regulation through his role as a national expert to the European Medicines Agency.

Research

 

Guthrie B. Davis S, Donnan P, Payne K, Morales DR (CA), Thompson A. Accounting for multimorbidity, competing risk and direct treatment disutility in risk prediction tools and model-based cost-effectiveness analysis for the primary prevention of cardiovascular disease and osteoporotic fracture. NIHR Health Services and Delivery Research Programme. In progress.

Morales DR (PI), Donnan PT, Lipworth B. Respiratory effect of angiotensin-converting enzyme inhibitors in people with asthma: a pharmacoepidemiological analysis using linked UK primary care data. Tenovus Scotland Major Research Grant. June 2016 to Sep 2017.

Morales DR (PI), Zhang J, Flynn R. Application of support vector machine learning to predict the risk of death from chronic obstructive pulmonary disease using electronic primary care medical records. Chief Scientist Office. July 2015 to July 2016.

Mead G, Hankey G, Lewis S, Graham C, Anderson C, Hackett M, House AO, Sullivan F, Morales DR (CA), Macleod M, Murray V, Lundström E, Dennis M. A Multicentre randomised trial to establish the effect (s) of routine administration of Fluoxetine in patients with a recent stroke. NIHR Health Technology Assessment Programme. Oct 2014 to March 2019.

Morales DR (PI), Donnan P, Jackson C, Guthrie B. Measuring the risk of ß-blocker and NSAID prescribing in asthma. Chief Scientist Office, Scottish Government Health Department Clinical Academic Fellowship. Sep 2011 to Sep 2014.

Dreischulte T, Morales DR (Co-PI), Guthrie B, Donnan PT. Risk of renal events following triple whammy exposure. NHS Tayside Anonymous Trust Grant. Aug 2012 to Aug 2014.

Marwick C, Morales DR (Co-PI), Donnan PT. Validation of a clinical prediction rule for community acquired Clostridium difficile infection after antibiotic prescription in older patients. NHS Tayside Anonymous Trust Grant. Sep 2013 to Dec 2014.

Teaching

Dr Morales leads the Research Methods module on the Kuwait-Scotland MSc in Diabetes Care and Education and is a Masters student supervisor. He also supervises postgraduate trainee doctors during his clinical practice and has previously been involved in undergraduate teaching and examining on the medical curriculum.

Publications

Morales DR, Slattery J, Evans S, Kurz X. Antidepressant use during pregnancy and risk of autism spectrum disorder and attention deficit hyperactivity disorder: systematic review of observational studies and methodological considerations. BMC Med. 2018 Jan 15;16(1):6.

Goedecke T, Morales DR, Pacurariu A, Kurz X. Measuring the impact of medicines regulatory interventions - Systematic review and methodological considerations. Br J Clin Pharmacol. 2017 Nov 5. doi: 10.1111/bcp.13469. [Epub ahead of print].

Nissen F, Morales DR, Mullerova H, Smeeth L, Douglas IJ, Quint JK. Validation of asthma recording in the Clinical Practice Research Datalink (CPRD). BMJ Open. 2017;7(8):e017474.

Weatherburn CJ, Guthrie B, Mercer SW, Morales DR. Comorbidities in adults with asthma: Population-based cross-sectional analysis of 1.4 million adults in Scotland. Clin Exp Allergy. 2017 Jun 30. doi: 10.1111/cea.12971.

Bahri P, Fogd J, Morales D, Kurz X; ADVANCE consortium. Application of real-time global media monitoring and 'derived questions' for enhancing communication by regulatory bodies: the case of human papillomavirus vaccines. BMC Med. 2017;15(1):91.

Morales DR, Guthrie B. Off-label prescribing of antidepressants. BMJ. 2017;356:j849.

Morales DR, Lipworth BJ, Donnan PT, Jackson C, Guthrie B. Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study. BMC Med. 2017;15(1):18.

Ruscitto A, Mercer SW, Morales D, Guthrie B. Accounting for multimorbidity in pay for performance: a modelling study using UK Quality and Outcomes Framework data. Br J Gen Pract. 2016;66(649):e561-7.

Morales DR, Dreischulte T, Lipworth BJ, Donnan PT, Jackson C, Guthrie B. Respiratory effect of beta-blocker eye drops in asthma: population based study and meta-analysis of clinical trials. Br J Clin Pharmacol. 2016 May 10.

Morales DR, Guthrie B, Lipworth BJ, Jackson C, Donnan PT, Santiago VH. NSAID-exacerbated respiratory disease: a meta-analysis evaluating prevalence, mean provocative dose of aspirin and increased asthma morbidity. Allergy. 2015;70:828-35.

Dreischulte T, Morales DR, Bell S, Guthrie B. Combined use of nonsteroidal anti-inflammatory drugs with diuretics and/or renin-angiotensin system inhibitors in the community increases the risk of acute kidney injury. Kidney Int. 2015;88:396-403.

Morales DR, Morris AD. Metformin in Cancer Treatment and Prevention. Annu Rev Med. 2015;66:17-29.

Morales DR. Initiating beta-blockers in people with asthma. Prescriber. 2014;25:9-10.

Guthrie B, Morales DR. What happens when pay for performance stops? BMJ. 2014;348:g1413.

Morales DR, Jackson C, Lipworth BL, Donnan PT, Guthrie B. Adverse respiratory effect of acute beta-blocker exposure in asthma: a systematic review and meta-analysis of randomized controlled trials. Chest. 2014;145:779-86.

Morales DR, Lipworth BL, Guthrie B, Jackson C, Donnan PT, Santiago VH. Safety risks for patients with aspirin-exacerbated respiratory disease after acute exposure to selective nonsteroidal anti-inflammatory drugs and COX-2 inhibitors: Meta-analysis of controlled clinical trials. J Allergy Clin Immunol. 2014; 134: 40-45

Morales DR. LABA monotherapy in asthma. Br J Gen Pract. 2013;63(617):627-8.

Guthrie B, Clark SA, Reynish EL, McCowan C, Morales DR. Differential impact of two risk communications on antipsychotic prescribing to people with dementia in Scotland: segmented regression time series analysis 2001-2011. PLoS One. 2013;8(7):e68976.

Morales DR, Donnan PT, Daly F, van Staa T, Sullivan FM. Impact of clinical trial findings on Bell’s palsy management in the United Kingdom 2001-2012: interrupted time series regression analysis. BMJ Open. 2013;3(7).

Morales DR, Jackson C, Fielding S, Guthrie B. Long-acting ?-agonist prescribing in people with asthma in primary care. Thorax. 2013;68:192-4.

Morales DR, Guthrie B, Lipworth BJ, Donnan PT, Jackson C. Prescribing of ?-adrenoceptor antagonists in asthma: an observational study. Thorax. 2011;66:502-7.

Ziglam H, Morales D, Webb K, Nathwani D. Knowledge about sepsis among training-grade doctors. J Antimicrob Chemother. 2006;57:963-65.

Wemyss-Holden SA, Court FG, Morrison CP, Teague BD, Burrell A, Morales DR, Rodgers N, Anthony AA, Metcalfe MS, Dennison AR, Maddern GJ. Palliation of pancreatic cancer using electrolytic ablation. Surg Endosc. 2003;17:207-11.