Colin Murdoch

+44 (0)1382 383526
Senior Lecturer

Bio

Biography

Dr Colin Murdoch obtained his doctorate under the supervision of Prof Ajay Shah through the British Heart Foundation 4-year Ph.D program at the BHF Cardiovascular Centre of Excellence, King’s College London. He investigated the “Influence of endothelial NADPH oxidase on cardiac fibrosis and remodelling in the hypertensive heart.”  utilising murine cardiovascular techniques such as pressure-volume loops, echocardiography and telemetry.

Dr Murdoch conducted post-doctoral training with Richard Cohen and Reiko Matsui at the Whitaker Cardiovascular Institute, Boston University investigating redox signalling in neovascularisation in type-2 diabetes. He moved back to the UK and was awarded a highly competitive Marie Skłodowska-Curie International Incoming Fellowship to transfer in vivo cardiovascular phenotyping techniques to Aston Medical School working in Prof Asif Ahmed’s laboratory.

Previously he worked as a functional pharmacologist for 5-years at Asterand Biosceince after gaining his honours degree in Pharmacology with Industrial Experience at University of Edinburgh.

Dr Murdoch joined the faculty at School of Medicine, University of Dundee in March 2018.  His research focuses on the pathophysiological role of redox signalling in cardiovascular disease including preeclampsia and peripheral artery disease.   Dr Murdoch is the project coordinator for EU Horizon2020 Innovative training network, iPLACENTA.  Involving a collaborative training network between 11 institutes across Europe.

Research

Dr Murdoch’s research aims to understand the pathophysiological role of redox signalling in cardiovascular disease, focusing on signalling in the endothelium.  Currently he is investigating how oxidative post-translational modification of thiols contribute to the preeclampsia phenotype. 

 

Dr Murdoch is the coordinator of iPLACENTA, a €3.9 million Horizon 2020 innovative training network (ITN).   A multi-disciplinary network of 11 European partners delivering post-graduate training for 15 Early stage researchers (ESRs/Ph,D).  The principal research aim of iPLACENTA is to improve the ability to study, model and visualise the placenta to enhance investigation and prognosis of complicated pregnancies such as preeclampsia and intrauterine growth restriction.   Integrating organ-chip technology and mathematical modelling, with innovation in visualising and assessing placenta health in the clinic and pre-clinical models.   The research will interconnect to unlock the complexity of placental disease, providing mechanistic clues for complex diseases, new ways to model placenta function, validate novel clinical diagnostic tools and characterise in vivo pre-clinical models.   The PhD training programme aims to equip the ESRs with the necessary skills to meet the challenges of cutting-edge translational research alongside topics such as OpenScience, entrepreneurship, project management and business skills.   See  www.iplacenta.eu

 

Publications

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor
4/2018, Cell Death and Disease
Research Output: Contribution To Journal > Article

Therapeutic Angiogenesis of Chinese Herbal Medicines in Ischemic Heart Disease
4/2018, Frontiers in Pharmacology
Research Output: Contribution To Journal > Review article

Vascular endothelial growth factor signaling requires glycine to promote angiogenesis
10/2017, Scientific Reports
Research Output: Contribution To Journal > Article

Differential regulation of ischemic limb vascularization and tumor growth by endothelial glutaredoxin-1
11/2017, Free Radical Biology and Medicine
Research Output: Contribution To Journal > Meeting abstract

Redox regulation of ischemic limb neovascularization - What we have learned from animal studies
4/2017, Redox Biology
Research Output: Contribution To Journal > Review article

Protein thiol modifications in the development of the 'preeclampsia phenotype'
7/2017, Free Radical Biology and Medicine
Research Output: Contribution To Journal > Meeting abstract

The impact of environmental factors in influencing epigenetics related to oxidative states in the cardiovascular system
4/2017, Oxidative Medicine and Cellular Longevity
Research Output: Contribution To Journal > Review article

Distinct regulatory effects of myeloid cell and endothelial cell Nox2 on blood pressure
3/2017, Circulation
Research Output: Contribution To Journal > Article

Heterodimerisation between VEGFR-1 and VEGFR-2 and not the homodimers of VEGFR-1 inhibit VEGFR-2 activity
11/2016, Vascular Pharmacology
Research Output: Contribution To Journal > Article

Cell-specific effects of Nox2 on the acute and chronic response to myocardial infarction
7/2016, Journal of Molecular and Cellular Cardiology
Research Output: Contribution To Journal > Article

View full profile on research portal

Press

The Science Of Safer Pregnancy: How Mini 'Placentas On A Chip' May Help Us Understand Pre-eclampsia

Colin Murdoch

17/10/17

1 media contribution

Press/Media: Research