Colin J Henderson

+44 (0)1382 383130
Reader & Deputy Head of Division - Systems Medicine

Bio

Biography

My undergrdauate degree from the University of Edinburgh in Biochemistry (1981), was followed by a PhD in the Faculty of Medicine at the same institution. After undertaking a Celltech Training Fellowship at the MRC Reproductive Biology Unit in Edinburgh (1984-1987), I joined the Imperial Cancer Research Fund lab of Professor Roland Wolf, which relocated to the University of Dundee in January 1993. As part of ICRF, later Cancer Research UK, I became a senior, then Chief, Scientifc Officer, and later Associate, and then Staff, Scientist. I was appointed to an honorary lecturer position with the University of Dundee in 1999, formally joining the University in April 2011 as a Senior Lecturer in the School of Medicine, and being appointed Reader in 2018.

I am an enthusiastic advocate for outreach, and believe passionately that it is our duty as academics and scientists to clearly and openly communicate our work to the public. Ihave been extensively involved for >20 years in science communication and public engagement, both internally (Lab Tours, Open Days) and externally (School visits, Race/Relay for Life, charity & fundraising groups). In 2012, I was Ambassador of the Year (Researcher) in the CRUK ‘Flame of Hope’ awards. I was joint recipient of the Ian Stevenson Award for Public Engagement in 2016, and in 2017 I was appointed become Academic Lead for Public Engagement/Wider Impact for the School of Medicine, and represent the School on the University’s Public Engagement Forum.

I chair the Medical School Biological Services management committee, and I am the School of Medicine Representative on the University Welfare and Ethical use of animals committee. I sit on the National Centre for Reduction, Refinement and Replacment (NC3Rs) Studentship Committee.

Research

Trained as a biochemist, I have over 30 years’ experience working across disciplines in the areas of toxicology, drug metabolism and molecular pharmacology, which has made me a leader in these fields, with an international reputation for innovation. For more than two decades I have been at the cutting edge of transgenic model development, culminating in the generation of genetically altered mice designed to closely mirror human drug metabolism. These unique humanised mouse models havethe potential to create a paradigm shift in pre-clinical drug testing and clinical trial design, particularly addressing the increasing use of drug combinations in oncology. 

Over the last 15 years, my sustained research contributions and extensive knowledge of transgenic design and strategies has established me at the forefront of this area and internationally recognised amongst my peers, and I am regularly invited to speak, chair and participate at national/international conferences and symposia. 

I have established many local, national and international collaborations with both academic and industrial partners, resulting in a strong and sustained publication record. As well as several book chapters and reviews, I have published more than 100 peer-reviewed journal articles; my h-factor is 44 (Google Scholar, February 2018http://tinyurl.com/hth7bzq). My expertise in mouse work, and knowledge of transgenics, has led to my involvement in numerous projects, both across the University and nationally/internationally. Since joining the University in 2011, I have been instrumental in securing more than £5M of grant funding, including two MRC Project grants (2017, 2018) worth >£2M. I regularly review manuscripts submitted for publication to a range of journals, and review grant applications for national funding bodies.

Teaching

Undergraduate: I deliver lectures to science and medical students, mainly in the area of toxicology, drug metabolism and transgenic models. I currently participate in BS50003 MSci Integrated Masters, BS42007 Cancer Biology, BS42027 Cancer Pharmacology, BMSc 40036, BS32029 Biomedical Sciences  and SSC components for Medicine.

Postgraduate: I have been involved in the supervision of a number of graduate students; I am currently primary supervisor to one graduate student. I also participate in, and help run, MRes Cancer Biology

PhD & MSc Examinations:I have been Convenor or Internal Examiner for MSc and PhD theses in the Medical School, and External Examiner at a number of UK academic institutions.

Publications

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice
8/2019, Drug Metabolism and Disposition
Research Output: Contribution To Journal > Article

Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo
7/2019, Archives of Toxicology
Research Output: Contribution To Journal > Article

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials
6/2019, Drug Metabolism and Disposition
Research Output: Contribution To Journal > Article

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine
3/2019, Toxicology and Applied Pharmacology
Research Output: Contribution To Journal > Article

Constitutive androstane receptor 1 is constitutively bound to chromatin and ‘primed’ for transactivation in hepatocytes
1/2019, Molecular Pharmacology
Research Output: Contribution To Journal > Article

Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy
5/2018, Clinical Cancer Research
Research Output: Contribution To Journal > Article

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation : studies in hepatic cytochrome b5 /P450 reductase null (HBRN) mice
4/2018, Archives of Toxicology
Research Output: Contribution To Journal > Article

Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse
1/2018, Journal of Physiology
Research Output: Contribution To Journal > Article

Editorial : Role of protein-protein interactions in metabolism: Genetics, structure, function
11/2017, Frontiers in Pharmacology
Research Output: Contribution To Journal > Editorial

Novel Pathways Of Ponatinib Disposition Catalysed By CYP1A1 Involving Generation Of Potentially Toxic Metabolites
10/2017, Journal of Pharmacology and Experimental Therapeutics
Research Output: Contribution To Journal > Article

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Press

Research could prompt changes in cancer treatment

Colin Henderson

20/03/18

1 item of Media coverage

Press/Media: Research



Dundee takes lead role in supporting cancer drugs development

Colin Henderson

4/05/10

1 item of Media coverage

Press/Media: Research



Scientists reveal 'protector' gene behind 50-fold increase in number of bowel tumours

Colin Henderson

24/09/09

1 item of Media coverage

Press/Media: Research



Cash award for cancer researchers

Colin Henderson

9/09/05

1 item of Media coverage

Press/Media: Research



New insight into how paracetamol overdoses can damage liver

Colin Henderson

6/11/00

1 item of Media coverage

Press/Media: Research



Painkiller overdose unravelled

Colin Henderson

6/11/00

1 item of Media coverage

Press/Media: Research



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Activities

Lochside Primary School

Colin Henderson (Member), Lesley C. McFarlane (Member), Jenny Johnston (Member), Celine Pourreyron (Member)
25 Jun 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

Tealing Primary School

Colin Henderson (Member), Nicola Morrice (Member), Rita Moreno Dorta (Member)
20 Jun 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

Forfar Academy

Colin Henderson (Member), Colin Murdoch (Member), Agathe Lermant (Member)
18 Jun 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

Our Lady Primary School

Colin Henderson (Member), Jenny Johnston (Member), Lesley C. McFarlane (Member), Daniella Cavellini (Member)
17 Jun 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

Maisondieu Primary School

Colin Henderson (Member), Celine Pourreyron (Member), Kimberley Morrison (Member), Suzanne Zaremba (Member)
10 Jun 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

St Margaret's Primary School

Colin Henderson (Member)
4 Jun 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

Inverbrothock Primary School (2)

Colin Henderson (Member), Ros Langston (Member), Rita Moreno Dorta (Member)
31 May 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

Inverbrothock Primary School (1)

Colin Henderson (Member), Amy Rogers (Member), Lesley C. McFarlane (Member), Nicola Morrice (Member)
24 May 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

Edzell Primary Schol

Colin Henderson (Member), Jenny Johnston (Member), Lesley C. McFarlane (Member)
17 May 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

Carlogie Primary School

Colin Henderson (Member), Rita Moreno Dorta (Member), Nicola Morrice (Member), Daniella Cavellini (Member)
15 May 2019

Activity: Other activity typesSchools engagement

Activity Type: Other Activity

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