Christopher Barratt

+44 (0)1382 383398
Head of Division - Systems Medicine & Professor of Reproductive Medicine

Bio

Biography

Professor Barratt is Head of Division Systems Medicine, Head of the Reproductive Medicine Group at the University of Dundee as well as a clinical scientist (Hon) with NHS Tayside. He graduated with an Honours degree in Zoology and then completed a Post Graduate Certificate in Education (University of Wales, Swansea). His PhD, also in Zoology, was under the supervision of Jack Cohen at the University of Birmingham.

His formative post-doctoral studies and ART experience was gained at the University of Sheffield [with Ian Cooke] where they specialized in natural cycle IVF. From 1997-2005 he was the Scientific Director of the ART Centre at the Birmingham Women’s Hospital.

Professor Barratt has been awarded a number of honors for outstanding contributions to the discipline e.g. Young Andrologist of the Year (American Andrology Society), the Professor Sir Robert Edwards keynote lecture at ESHRE.

He is a regularly invited speaker at national and international scientific conferences/workshops. He was a member of the WHO Male Fertility Semen Analysis Taskforce (for both the 4th and 5th editions) and director of the WHO (2012-2017) Male Fertility Expert Working Group which devised a new system for the diagnosis and treatment of the infertile male  (https://academic.oup.com/humupd/article/23/6/660/3979420). He was a member of the Human Fertilisation and Embryology Authority for 6 years.

Professor Barratt has recently been appointed to editorial board of WHO for development of new Semen Analysis manual (6th edition).

He has been on the Editorial Board of Human Reproduction, Human Fertility, Biology of Reproduction, Human Reproduction Update, Journal of Andrology and is currently Editor-in-Chief of Molecular Human Reproduction (Impact factor 5 year 3.6)

 

His life’s ambition is to see - live - Wales comprehensively beat the All Blacks.

Research

We are primarily focused on understanding the function of the human spermatozoa and identifying the key factors in the process of sperm egg interation.

Our research uses cutting edge technology combined with selected samples from patients with well-defined pathology. As such the research has a very strong translational focus.

Our primary collaborators in Dundee are the IVF clinic at NHS Tayside, Abertay University's Dr Sean Brown, Professor Paul Wyatt (Drug Discovery Unit, SLS), and Paul Andrews (National Phenotypic Screening Centre, SLS http://npsc.ac.uk/)

We are funded by NHS Tayside, MRC, Chief Scientists Office (Scotland), Astra Zeneca and the Bill and Melinda Gates Foundation.

We regularly contribute to public debates on reproductive issues: e.g. impact of male age https://www.bionews.org.uk/page_135205

Patents

  • Inventor: Barratt C (CMDN) & Wyatt PG (CLS) ‘Stimulation of human sperm motility’. International application number: PCT/GB2012/052514. Publication number WO/2013/054111. Publication date 18th April 2013.
  • Inventor: Genosis & Barratt C ‘Method and detection kit for male infertility’ 1999. WO/99066331

Teaching

Professor Barratt has supervised 29 MSc, PhD, MD students almost all of whom work in in the field of reproductive medicine.

His teaching consists of:

Supervisor: 9 MSc/PhD students

Leader: SSC in Stem Cells and Assisted Conception

Leader: Human Reproduction, Assisted Conception and Embryonic Stem Cells BMSc

Leader: Human Clinical Embryology and Assisted Conception MSc.

 

External examiner (previous)

  • Quinquennial Review MSc for ART at University of Oxford (2014).
  • MSc for Reproductive and Developmental Biology at University of Edinburgh (2009-2013).
  • United Arab Emirates Ministry of Higher Education and Scientific Research (2012-2013).
  • 3rd year Reproductive Biology course at University of Edinburgh (2015-16).
  • Endocrine and Reproduction Course (MDSC 2101) University West Indies 2014-2017.
  • University of Nottingham (2004-2006).
  • MSc in Embryology at the University of Leeds (2002-2004).
  • MSc ART University of Bristol (2002-2005).

Publications

Brown, SG, Miller, MR, Lishko, PV, Lester, DH, Publicover, SJ, Barratt, CLR & Martins Da Silva, S 2018,

'Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of Cat Sper function and compromised fertilizing capacity' Human Reproduction, vol. 33, no. 10, pp. 1812-1816.
https://doi.org/10.1093/humrep/dey278

Research output: Contribution To Journal



Andersen, CY, Kristensen, SG, Mamsen, LS & Barratt, C 2018,

'Education, education, education: now more than ever?' Molecular Human Reproduction, vol. 24, no. 8, pp. 426-429.
https://doi.org/10.1093/molehr/gay028

Research output: Contribution To Journal



Barratt, CLR 2018,

'A Dolce & Gabbana model in every ART clinic?' Molecular Human Reproduction, vol. 24, no. 9, gay030, pp. 431-432.
https://doi.org/10.1093/molehr/gay030

Research output: Contribution To Journal



Kelly, MC, Brown, SG, Costello, SM, Ramalingam, M, Drew, E, Publicover, SJ, Barratt, CLR & Martins Da Silva, S 2018,

'Single-cell analysis of [Ca2+]i signalling in sub-fertile men: characteristics and relation to fertilization outcome' Human Reproduction, vol. 33, no. 6, pp. 1023-1033.
https://doi.org/10.1093/humrep/dey096

Research output: Contribution To Journal



ESHRE Capri Workshop Group 2018,

'Protect us from poor-quality medical research' Human Reproduction, vol. 33, no. 5, pp. 770-776.
https://doi.org/10.1093/humrep/dey056

Research output: Contribution To Journal



Barratt, CLR, De Jonge, CJ & Sharpe, RM 2018,

'‘Man Up’: the importance and strategy for placing male reproductive health centre stage in the political and research agenda.' Human Reproduction, vol. 33, no. 4, pp. 541-545.
https://doi.org/10.1093/humrep/dey020

Research output: Contribution To Journal



Barratt, CLR 2018,

'People are very open-minded about new things, as long as they are exactly like the old ones' Molecular Human Reproduction, vol. 24, no. 1, pp. 1.
https://doi.org/10.1093/molehr/gax066

Research output: Contribution To Journal



Brown, SG, Costello, S, Kelly, M, Ramalingam, M, Drew, E, Publicover, SJ, Barratt, C & Martins Da Silva, S 2017,

'Complex Cat Sper-dependent and independent [Ca2+] signaling induced by human follicular fluid' Human Reproduction, vol. 32, no. 10, pp. 1995-2006.
https://doi.org/10.1093/humrep/dex269

Research output: Contribution To Journal



Barratt, CLR, Bjorndahl, L, De Jonge, CJ, Lamb, DJ, Martini, FO, Mc Lachlan, R, Oates, RD, van der Poel, S, St John, B, Sigman, M, Sokol, R & Tournaye, H 2017,

'The diagnosis of male infertility: an analysis of the evidence to support the developments of global WHO guidance. Challenges and future research opportunities' Human Reproduction Update, vol. 23, no. 6, pp. 660-680.
https://doi.org/10.1093/humupd/dmx021

Research output: Contribution To Journal



De Jonge, CJ & Barratt, CLR 2017, The sperm cell: Production, maturation, fertilization, regeneration. UNESCO/Cambridge University Press.
https://doi.org/10.1017/9781316411124

Research output: Book Anthology



De Jonge, CJ & Barratt, CLR 2017,

Current concepts and unresolved questions in human sperm cumulus and zona interaction. in The Sperm Cell: Production, Maturation, Fertilization, Regeneration. UNESCO/Cambridge University Press, pp. 152-156.
https://doi.org/10.1017/9781316411124.012

Research output: Contribution To Book Anthology



De Jonge, CJ & Barratt, CLR 2017,

Preface. in The Sperm Cell: Production, Maturation, Fertilization, Regeneration. UNESCO/Cambridge University Press, pp. xiii.
https://doi.org/10.1017/9781316411124.002

Research output: Contribution To Book Anthology



Martins Da Silva, SJ, Brown, SG, Sutton, K, King, LV, Ruso, H, Gray, DW, Wyatt, PG, Kelly, MC, Barratt, CLR & Hope, AG 2017,

'Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem' Human Reproduction, vol. 32, no. 5, pp. 974-984.
https://doi.org/10.1093/humrep/dex055

Research output: Contribution To Journal



Barratt, CLR 2016,

'Lessons in Andrology: Thoughts for a Young Andrologist' Andrology, vol. 4, no. 6, pp. 987-989.
https://doi.org/10.1111/andr.12277

Research output: Contribution To Journal



Barratt, CLR 2016,

'Preimplantation genetic screening-23 years to navigate and translate into the clinical arena. We need a new roadmap!' Molecular Human Reproduction, vol. 22, no. 8, pp. 837-838.
https://doi.org/10.1093/molehr/gaw035

Research output: Contribution To Journal



Brown, SG, Publicover, SJ, Mansell, S, Lishko, PV, Williams, HL, Ramalingam, M, Wilson, SM, Barratt, CLR, Sutton, KA & Da Silva, SM 2016,

'Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF' Human Reproduction, vol. 31, no. 6, pp. 1147-1157.
https://doi.org/10.1093/humrep/dew056

Research output: Contribution To Journal



Barratt, CLR 2016,

''Single cell analysis in development' special series' Molecular Human Reproduction, vol. 22, no. 3, pp. 159.
https://doi.org/10.1093/molehr/gaw010

Research output: Contribution To Journal



Fernandes, G, Dasai, N, Kozlova, N, Mojadadi, A, Gall, M, Drew, E, Barratt, E, Madamidola, OA, Brown, SG, Milne, AM, Martins Da Silva, SJ, Whalley, KM, Barratt, CLR & Jovanovic, A 2016,

'A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels' Human Reproduction, vol. 31, no. 2, pp. 287-297.
https://doi.org/10.1093/humrep/dev300

Research output: Contribution To Journal



Björndahl, L, Barratt, CLR, Mortimer, D & Jouannet, P 2016,

''How to count sperm properly': checklist for acceptability of studies based on human semen analysis' Human Reproduction, vol. 31, no. 2, pp. 227-232.
https://doi.org/10.1093/humrep/dev305

Research output: Contribution To Journal



Barratt, CLR 2016,

'Is there a robust future for research in reproduction?' Molecular Human Reproduction, vol. 22, no. 1, pp. 1-2.
https://doi.org/10.1093/molehr/gav062

Research output: Contribution To Journal



Williams, HL, Mansell, S, Alasmari, W, Brown, SG, Wilson, SM, Sutton, KA, Miller, MR, Lishko, PV, Barratt, CLR, Publicover, SJ & Martins da Silva, S 2015,

'Specific loss of Cat Sper function is sufficient to compromise fertilizing capacity of human spermatozoa' Human Reproduction, vol. 30, no. 12, pp. 2737-2746.
https://doi.org/10.1093/humrep/dev243

Research output: Contribution To Journal



Petraglia, F, Barratt, CLR & Evers, JLH 2015,

'Clarification of scope for Human Reproduction and Molecular Human Reproduction' Human Reproduction Update, vol. 21, no. 5, pp. 559.
https://doi.org/10.1093/humupd/dmv033

Research output: Contribution To Journal



Yelumalai, S, Yeste, M, Jones, C, Amdani, SN, Kashir, J, Mounce, G, Martins Da Silva, SJ, Barratt, CL, Mc Veigh, E & Coward, K 2015,

'Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection' Fertility and Sterility, vol. 104, no. 3, pp. 561-568.e4.
https://doi.org/10.1016/j.fertnstert.2015.05.018

Research output: Contribution To Journal



Sakkas, D, Ramalingam, M, Garrido, N & Barratt, C 2015,

'Sperm selection in natural conception: what can we learn from Mother Nature to improve assisted reproduction outcomes?' Human Reproduction Update, vol. 21, no. 6, pp. 711-726.
https://doi.org/10.1093/humupd/dmv042

Research output: Contribution To Journal



Tardif, S, Madamidola, OA, Brown, SG, Frame, L, Lefièvre, L, Wyatt, PG, Barratt, CLR & Martins Da Silva, SJ 2014,

'Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity' Human Reproduction, vol. 29, no. 10, pp. 2123-2135.
https://doi.org/10.1093/humrep/deu196

Research output: Contribution To Journal



Tournaye, H, Dohle, GR & Barratt, CLR 2014,

'Fertility preservation in men with cancer' Lancet, vol. 384, no. 9950, pp. 1295-1301.
https://doi.org/10.1016/S0140-6736(14)60495-5

Research output: Contribution To Journal



Dorin, JR & Barratt, CLR 2014,

'Importance of β-defensins in sperm function' Molecular Human Reproduction, vol. 20, no. 9, pp. 821-826.
https://doi.org/10.1093/molehr/gau050

Research output: Contribution To Journal



Mansell, SA, Publicover, SJ, Barratt, CLR & Wilson, SM 2014,

'Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels' Molecular Human Reproduction, vol. 20, no. 5, pp. 392-408.
https://doi.org/10.1093/molehr/gau003

Research output: Contribution To Journal



Barratt, CLR 2013,

'MHR celebration issue in tribute to Professor Sir Robert Edwards' Molecular Human Reproduction, vol. 19, no. 12, pp. 783-784.
https://doi.org/10.1093/molehr/gat074

Research output: Contribution To Journal



Tavares, RS, Mansell, S, Barratt, CLR, Wilson, SM, Publicover, SJ & Ramalho-Santos, J 2013,

'p,p'-DDE activates Cat Sper and compromises human sperm function at environmentally relevant concentrations' Human Reproduction, vol. 28, no. 12, pp. 3167-3177.
https://doi.org/10.1093/humrep/det372

Research output: Contribution To Journal



Zhou, YS, Webb, S, Lettice, L, Tardif, S, Kilanowski, F, Tyrrell, C, Macpherson, H, Semple, F, Tennant, P, Baker, T, Hart, A, Devenney, P, Perry, P, Davey, T, Barran, P, Barratt, CL & Dorin, JR 2013,

'Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice' PLo S Genetics, vol. 9, no. 10, e1003826, pp. 1-13.
https://doi.org/10.1371/journal.pgen.1003826

Research output: Contribution To Journal



Jones, S, Lukanowska, M, Suhorutsenko, J, Oxenham, S, Barratt, C, Publicover, S, Copolovici, DM, Langel, U & Howl, J 2013,

'Intracellular translocation and differential accumulation of cell-penetrating peptides in bovine spermatozoa: evaluation of efficient delivery vectors that do not compromise human sperm motility' Human Reproduction, vol. 28, no. 7, pp. 1874-1889.
https://doi.org/10.1093/humrep/det064

Research output: Contribution To Journal



Barratt, C & Wyatt, P 2013, Improved sperm function / activity, Patent No. WO2013054111 A1, IPC No. A61K31/519; A61P15/00; A61K31/52; A61K31/437; A61K45/00; A61K31/551; A61K39/395; A61K31/47.

Research output: Patent



Alasmari, W, Barratt, CLR, Publicover, SJ, Whalley, KM, Foster, E, Kay, V, Martins Da Silva, S & Oxenham, SK 2013,

'The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation' Human Reproduction, vol. 28, no. 4, pp. 866-876.
https://doi.org/10.1093/humrep/des467

Research output: Contribution To Journal



Mortimer, D, Barratt, CLR, Björndahl, L, de Jager, C, Jequier, AM & Muller, CH 2013,

'What should it take to describe a substance or product as 'sperm-safe'' Human Reproduction Update, vol. 19, no. SUPPL1, pp. i1-i45.
https://doi.org/10.1093/humupd/dmt008

Research output: Contribution To Journal



Alasmari, W, Costello, S, Correia, J, Oxenham, SK, Morris, J, Fernandes, L, Ramalho-Santos, J, Kirkman-Brown, J, Michelangeli, F, Publicover, S & Barratt, CLR 2013,

'Ca2+ signals generated by Cat Sper and Ca2+ stores regulate different behaviors in human sperm' Journal of Biological Chemistry, vol. 288, no. 9, pp. 6248-58.
https://doi.org/10.1074/jbc.M112.439356

Research output: Contribution To Journal



Special Interest Group in Andrology of the European Society of Human Reproduction and Embriology, Sánchez-Pozo, MC, Mendiola, J, Serrano, M, Mozas, J, Björndahl, L, Menkveld, R, Lewis, SEM, Mortimer, D, Jørgensen, N, Barratt, CLR, Fernández, MF & Castilla, JA 2013,

'Proposal of guidelines for the appraisal of SEMen QUAlity studies (SEMQUA)' Human Reproduction, vol. 28, no. 1, pp. 10-21.
https://doi.org/10.1093/humrep/des355

Research output: Contribution To Journal



Publicover, S, Correia, J, Alasmari, W & Barratt, C 2013,

'Controlling how sperm swim: Ca2+signals, Ca2+stores and Ca2+channels' Human Reproduction, vol. 28, no. S1, pp. i20-i21.
https://doi.org/10.1093/humrep/det140

Research output: Contribution To Journal



Lefièvre, L, Nash, K, Mansell, S, Costello, S, Punt, E, Correia, J, Morris, J, Kirkman-Brown, J, Wilson, SM, Barratt, CLR & Publicover, S 2012,

'2-APB-potentiated channels amplify Cat Sper-induced Ca signals in human sperm' Biochemical Journal, vol. 448, no. 2, pp. 189-200.
https://doi.org/10.1042/BJ20120339

Research output: Contribution To Journal



Publicover, SJ & Barratt, CLR 2012,

'Chloride channels join the sperm 'channelome'' Journal of Physiology, vol. 590, no. 11, pp. 2553-2554.
https://doi.org/10.1113/jphysiol.2012.234138

Research output: Contribution To Journal



Barratt, CLR & Publicover, SJ 2012,

'Sperm are promiscuous and Cat Sper is to blame...' EMBO Journal, vol. 31, no. 7, pp. 1624-1626.
https://doi.org/10.1038/emboj.2012.62

Research output: Contribution To Journal



Harper, J, Magli, MC, Lundin, K, Barratt, CLR & Brison, D 2012,

'When and how should new technology be introduced into the IVF laboratory?' Human Reproduction, vol. 27, no. 2, pp. 303-313.
https://doi.org/10.1093/humrep/der414

Research output: Contribution To Journal



Barratt, CLR, Bjoerndahl, L, Menkveld, R & Mortimer, D 2011,

'ESHRE special interest group for andrology basic semen analysis course: a continued focus on accuracy, quality, efficiency and clinical relevance' Human Reproduction, vol. 26, no. 12, pp. 3207-3212.
https://doi.org/10.1093/humrep/der312

Research output: Contribution To Journal



Matic, I, Jaffray, EG, Oxenham, SK, Groves, MJ, Barratt, CLR, Tauro, S, Stanley-Wall, NR & Hay, RT 2011,

'Absolute SILAC-compatible expression strain allows SUMO-2 copy number determination in clinical samples' Journal of Proteome Research, vol. 10, no. 10, pp. 4869-4875.
https://doi.org/10.1021/pr2004715

Research output: Contribution To Journal



Publicover, SJ & Barratt, CLR 2011,

'Sperm motility: things are moving in the lab!' Molecular Human Reproduction, vol. 17, no. 8, pp. 453-456.
https://doi.org/10.1093/molehr/gar048

Research output: Contribution To Journal



Barratt, CLR 2011,

'The mystery is solved-Cat Sper is the principal calcium channel activated by progesterone in human spermatozoa' Asian Journal of Andrology, vol. 13, no. 3, pp. 351-352.
https://doi.org/10.1038/aja.2011.9

Research output: Contribution To Journal



Koscinski, I, Ellnati, E, Fossard, C, Redin, C, Muller, J, de la Calle, JV, Schmitt, F, Ben Khelifa, M, Ray, PF, Kilani, Z, Barratt, CLR & Viville, S 2011,

'Erratum - DPY19L2 Deletion as a Major Cause of Globozoospermia' American Journal of Human Genetics, vol. 88, no. 4, pp. 517.
https://doi.org/10.1016/j.ajhg.2011.03.014

Research output: Contribution To Journal



Publicover, S & Barratt, C 2011,

'Reproductive biology: progesterone's gateway into sperm (vol 471, pg 313, 2011). Clarification' Nature, vol. 471, no. 7340, pp. 589-589.
https://doi.org/589-589 doi:10.1038/471589a

Research output: Contribution To Journal



Publicover, S & Barratt, C 2011,

'Reproductive biology: progesterone's gateway into sperm' Nature, vol. 471, no. 7338, pp. 313-314.
https://doi.org/10.1038/471313a

Research output: Contribution To Journal



Koscinski, I, Ellnati, E, Fossard, C, Redin, C, Muller, J, de la Calle, JV, Schmitt, F, Ben Khelifa, M, Ray, P, Kilani, Z, Barratt, CLR & Viville, S 2011,

'DPY19L2 Deletion as a Major Cause of Globozoospermia' American Journal of Human Genetics, vol. 88, no. 2011, pp. 344-350.
https://doi.org/10.1016/j.ajhg.2011.01.018

Research output: Contribution To Journal



Barratt, CLR, Mansell, S, Beaton, C, Tardif, S & Oxenham, SK 2011,

'Diagnostic tools in male infertility-the question of sperm dysfunction' Asian Journal of Andrology, vol. 13, no. 1, pp. 53-58.
https://doi.org/10.1038/aja.2010.63

Research output: Contribution To Journal



Koscinski, I, Elinati, E, Fossard, C, Kuentz, P, Kilani, Z, Demirol, A, Gurgan, T, Schmitt, F, de la Calle, JV, Iqbal, N, Louanjli, N, Pasquier, M, Carre-Pigeon, F, Muller, J, Barratt, C & Viville, S 2011,

'DPY19L2, its mutation in about half globozoospermia' Human Reproduction, vol. 26, no. S1, P-412, pp. i281 .
https://doi.org/10.1093/humrep/26.s1.89

Research output: Contribution To Journal



Du, Q, Jovanovic, S, Sukhodub, A, Barratt, E, Drew, E, Whalley, KM, Kay, V, Mc Laughlin, M, Telfer, EE, Barratt, CLR & Jovanovic, A 2010,

'Human oocytes express ATP-sensitive K+ channels' Human Reproduction, vol. 25, no. 11, pp. 2774-2782.
https://doi.org/10.1093/humrep/deq245

Research output: Contribution To Journal



Barratt, CLR & De Jonge, CJ 2010,

'Clinical relevance of sperm DNA assessment: an update' Fertility and Sterility, vol. 94, no. 6, pp. 1958-1959.
https://doi.org/10.1016/j.fertnstert.2010.07.1050

Research output: Contribution To Journal



Barratt, C 2010,

'The every expanding sperm tool kit' Human Reproduction, vol. 25, no. Suppl.1, O-201, pp. i80-i80.
https://doi.org/10.1093/humrep/de.25.s1.52

Research output: Contribution To Journal



Barratt, CLR, Aitken, RJ, Bjorndahl, L, Carrell, DT, de Boer, P, Kvist, U, Lewis, SEM, Perreault, SD, Perry, MJ, Ramos, L, Robaire, B, Ward, S & Zini, A 2010,

'Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications-a position report' Human Reproduction, vol. 25, no. 4, pp. 824-838.
https://doi.org/10.1093/humrep/dep465

Research output: Contribution To Journal



Barratt, CLR 2010,

'Male infertility joins the translational medicine revolution. Sperm DNA: from basic science to clinical reality' Molecular Human Reproduction, vol. 16, no. 1, pp. 1-2.
https://doi.org/10.1093/molehr/gap094

Research output: Contribution To Journal



Costello, S, Michelangeli, F, Nash, K, Lefievre, L, Morris, J, Machado-Oliveira, G, Barratt, C, Kirkman-Brown, J & Publicover, S 2009,

'Ca2+-stores in sperm: their identities and functions' Reproduction, vol. 138, pp. 425-437.
https://doi.org/10.1530/REP-09-0134

Research output: Contribution To Journal



Barratt, CL 2009,

'Investigating infertility in primary care' Practitioner, vol. 253, no. 1716, pp. 26-28.

Research output: Contribution To Journal



Kay, VJ & Barratt, CLR 2009,

'Male obesity: impact on fertility' British Journal of Diabetes and Vascular Disease, vol. 9, no. 5, pp. 237-241.
https://doi.org/10.1177/1474651409343132

Research output: Contribution To Journal



Lefièvre, L, Machado-Oliveira, G, Ford, C, Kirkman-Brown, J, Barratt, C & Publicover, S 2009,

'Communication between female tract and sperm: saying NO* when you mean yes' Communicative & Integrative Biology, vol. 2, no. 2, pp. 82-5.

Research output: Contribution To Journal



Barratt, CLR, Kay, V & Oxenham, SK 2009,

'The human spermatozoon: a stripped down but refined machine' Journal of Biology, vol. 8, no. 7, pp. 63.
https://doi.org/10.1186/jbiol167

Research output: Contribution To Journal



Barratt, CL, Harrison, PE, Robinson, A, Kessopoulou, E & Cooke, ID 2008,

'Seminal white blood cells in men with urethral tract infection. A monoclonal antibody study' British Journal of Urology, vol. 68, no. 5, pp. 531-6.

Research output: Contribution To Journal



Barratt, CLR 2008,

'The human sperm proteome: the potential for new biomarkers of male fertility and a transformation in our understanding of the spermatozoon as a machine' Human Reproduction, vol. 23, no. 6, pp. 1240-1241.
https://doi.org/10.1093/humrep/den019

Research output: Contribution To Journal



Bedu-Addo, K, Costello, S, Harper, C, Machado-Oliveira, G, Lefievre, L, Ford, C, Barratt, C & Publicover, S 2008,

'Mobilisation of stored calcium in the neck region of human sperm: a mechanism for regulation of flagellar activity' International Journal of Developmental Biology, vol. 52, no. 5-6, pp. 615-626.
https://doi.org/10.1387/ijdb.072535kb

Research output: Contribution To Journal



Machado-Oliveira, G, Lefievre, L, Ford, C, Herrero, MB, Barratt, C, Connolly, TJ, Nash, K, Morales-Garcia, A, Kirkman-Brown, J & Publicover, S 2008,

'Mobilisation of Ca2+ stores and flagellar regulation in human sperm by S-nitrosylation: a role for NO synthesised in the female reproductive tract' Development, vol. 135, no. 22, pp. 3677-3686.
https://doi.org/10.1242/dev.024521

Research output: Contribution To Journal



Publicover, SJ, Giojalas, LC, Teves, ME, de Oliveira, GSMM, Garcia, AAM, Barratt, CLR & Harper, CV 2008,

'Ca2+ signalling in the control of motility and guidance in mammalian sperm' Frontiers in Bioscience, vol. 13, 3105, pp. 5623-5637.
https://doi.org/10.2741/3105

Research output: Contribution To Journal



Jiménez-González, MC, Gu, Y, Kirkman-Brown, J, Barratt, CLR & Publicover, S 2007,

'Patch-clamp 'mapping' of ion channel activity in human sperm reveals regionalisation and co-localisation into mixed clusters' Journal of Cellular Physiology, vol. 213, no. 3, pp. 801-808.
https://doi.org/10.1002/jcp.21153

Research output: Contribution To Journal



Bowdin, S, Allen, C, Kirby, G, Brueton, L, Afnan, M, Barratt, C, Kirkman-Brown, J, Harrison, R, Maher, ER & Reardon, W 2007,

'A survey of assisted reproductive technology births and imprinting disorders' Human Reproduction, vol. 22, no. 12, pp. 3237-3240.
https://doi.org/10.1093/humrep/dem268

Research output: Contribution To Journal



Lefièvre, L, Chen, Y, Conner, SJ, Scott, JL, Publicover, SJ, Ford, WCL & Barratt, CLR 2007,

'Human spermatozoa contain multiple targets for protein S-nitrosylation: An alternative mechanism of the modulation of sperm function by nitric oxide?' Proteomics, vol. 7, no. 17, pp. 3066-3084.
https://doi.org/10.1002/pmic.200700254

Research output: Contribution To Journal



Ellis, PJI, Furlong, RA, Conner, SJ, Kirkman-Brown, J, Afnan, M, Barratt, C, Griffin, DK & Affara, NA 2007,

'Coordinated transcriptional regulation patterns associated with infertility phenotypes in men' Journal of Medical Genetics, vol. 44, no. 8, pp. 498-508.
https://doi.org/10.1136/jmg.2007.049650

Research output: Contribution To Journal



Lefièvre, L, Bedu-Addo, K, Conner, SJ, Machado-Oliveira, GSM, Chen, Y, Kirkman-Brown, JC, Afnan, MA, Publicover, SJ, Ford, WCL & Barratt, CLR 2007,

'Counting sperm does not add up any more: time for a new equation?' Reproduction, vol. 133, no. 4, pp. 675-684.
https://doi.org/10.1530/REP-06-0332

Research output: Contribution To Journal



Publicover, S, Harper, CV & Barratt, C 2007,

'[Ca2+]i signalling in sperm--making the most of what you've got' Nature Cell Biology, vol. 9, no. 3, pp. 235-242.
https://doi.org/10.1038/ncb0307-235

Research output: Contribution To Journal



Bedu-Addo, K, Barratt, CLR, Kirkman-Brown, JC & Publicover, SJ 2007,

'Patterns of [Ca2+](i) mobilization and cell response in human spermatozoa exposed to progesterone' Developmental Biology, vol. 302, no. 1, pp. 324-32.
https://doi.org/10.1016/j.ydbio.2006.09.040

Research output: Contribution To Journal



Conner, SJ, Lefièvre, L, Kirkman-Brown, J, Michelangeli, F, Jimenez-Gonzalez, C, Machado-Oliveira, GSM, Pixton, KL, Brewis, IA, Barratt, CLR & Publicover, SJ 2007,

'Understanding the physiology of pre-fertilisation events in the human spermatozoa--a necessary prerequisite to developing rational therapy' Society of Reproduction and Fertility Supplement, vol. 63, pp. 237-255.

Research output: Contribution To Journal



Mortimer, D & Barratt, CLR 2006,

'Is there a real risk of transmitting variant Creutzfeldt-Jakob disease by donor sperm insemination?' Reproductive biomedicine online, vol. 13, no. 6, pp. 778-790.
https://doi.org/10.1016/S1472-6483(10)61024-3

Research output: Contribution To Journal



Harper, CV, Barratt, CLR, Publicover, SJ & Kirkman-Brown, JC 2006,

'Kinetics of the progesterone-induced acrosome reaction and its relation to intracellular calcium responses in individual human spermatozoa' Biology of Reproduction, vol. 75, no. 6, pp. 933-939.
https://doi.org/10.1095/biolreprod.106.054627

Research output: Contribution To Journal



Billington, RA, Harper, C, Bellomo, EA, Publicover, S, Barratt, CLR & Genazzani, AA 2006,

'Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa' Fertility and Sterility, vol. 86, no. 4, pp. 891-8.
https://doi.org/10.1016/j.fertnstert.2006.03.030

Research output: Contribution To Journal



Björndahl, L, Kirkman-Brown, J, Hart, G, Rattle, S & Barratt, CLR 2006,

'Development of a novel home sperm test' Human Reproduction, vol. 21, no. 1, pp. 145-9.
https://doi.org/10.1093/humrep/dei330

Research output: Contribution To Journal



Jimenez-Gonzalez, C, Michelangeli, F, Harper, CV, Barratt, CLR & Publicover, SJ 2005,

'Calcium signalling in human spermatozoa: a specialized 'toolkit' of channels, transporters and stores' Human Reproduction Update, vol. 12, no. 3, pp. 253-67.
https://doi.org/10.1093/humupd/dmi050

Research output: Contribution To Journal



Brewis, IA, Van Gestel, RA, Gadella, BM, Jones, R, Publicover, SJ, Roldan, ERS, Frayne, J & Barratt, CLR 2005,

'The spermatozoon at fertilisation: current understanding and future research directions' Human Fertility, vol. 8, no. 4, pp. 241-251.
https://doi.org/10.1080/14647270500420160

Research output: Contribution To Journal



Bedu-Addo, K, Lefièvre, L, Moseley, FLC, Barratt, CLR & Publicover, SJ 2005,

'Bicarbonate and bovine serum albumin reversibly 'switch' capacitation-induced events in human spermatozoa' Molecular Human Reproduction, vol. 11, no. 9, pp. 683-91.
https://doi.org/10.1093/molehr/gah426

Research output: Contribution To Journal



Moseley, FLC, Jha, KN, Björndahl, L, Brewis, IA, Publicover, SJ, Barratt, CLR & Lefièvre, L 2005,

'Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation' Molecular Human Reproduction, vol. 11, no. 7, pp. 523-529.
https://doi.org/10.1093/molehr/gah488

Research output: Contribution To Journal



Conner, SJ, Lefièvre, L, Hughes, DC & Barratt, CLR 2005,

'Cracking the egg: increased complexity in the zona pellucida' Human Reproduction, vol. 20, no. 5, pp. 1148-1152.
https://doi.org/10.1093/humrep/deh835

Research output: Contribution To Journal



Harper, C, Wootton, L, Michelangeli, F, Lefièvre, L, Barratt, C & Publicover, S 2005,

'Secretory pathway Ca(2+)-ATPase (SPCA1) Ca(2)+ pumps, not SERCAs, regulate complex [Ca(2+)](i) signals in human spermatozoa' Journal of Cell Science, vol. 118, no. Pt 8, pp. 1673-85.
https://doi.org/10.1242/jcs.02297

Research output: Contribution To Journal



St John, JC, Jokhi, RP & Barratt, CLR 2005,

'The impact of mitochondrial genetics on male infertility' International Journal of Andrology, vol. 28, no. 2, pp. 65-73.
https://doi.org/10.1111/j.1365-2605.2005.00515.x

Research output: Contribution To Journal



Kilani, Z, Ismail, R, Ghunaim, S, Mohamed, H, Brewis, I, Barratt, CLR & Hughes, D 2004,

'Evaluation and treatment of familial globozoospermia in five brothers' Fertility and Sterility, vol. 82, no. 5, pp. 1436-1439.
https://doi.org/10.1016/j.fertnstert.2004.03.064

Research output: Contribution To Journal



Harper, CV, Barratt, CLR & Publicover, SJ 2004,

'Stimulation of human spermatozoa with progesterone gradients to simulate approach to the oocyte. Induction of [Ca(2+)](i) oscillations and cyclical transitions in flagellar beating' Journal of Biological Chemistry, vol. 279, no. 44, pp. 46315-46325.
https://doi.org/10.1074/jbc.M401194200

Research output: Contribution To Journal



Gu, Y, Kirkman-Brown, JC, Korchev, Y, Barratt, CLR & Publicover, SJ 2004,

'Multi-state, 4-aminopyridine-sensitive ion channels in human spermatozoa' Developmental Biology, vol. 274, no. 2, pp. 308-17.
https://doi.org/10.1016/j.ydbio.2004.06.025

Research output: Contribution To Journal



Barratt, CLR, St John, JC & Afnan, M 2004,

'Clinical challenges in providing embryos for stem-cell initiatives' Lancet, vol. 364, no. 9429, pp. 115-8.
https://doi.org/10.1016/S0140-6736(04)16649-X

Research output: Contribution To Journal



Lefièvre, L, Conner, SJ, Salpekar, A, Olufowobi, O, Ashton, P, Pavlovic, B, Lenton, W, Afnan, M, Brewis, IA, Monk, M, Hughes, DC & Barratt, CLR 2004,

'Four zona pellucida glycoproteins are expressed in the human' Human Reproduction, vol. 19, no. 7, pp. 1580-1586.
https://doi.org/10.1093/humrep/deh401

Research output: Contribution To Journal



Pixton, KL, Deeks, ED, Flesch, FM, Moseley, FLC, Björndahl, L, Ashton, PR, Barratt, CLR & Brewis, IA 2004,

'Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: case report' Human Reproduction, vol. 19, no. 6, pp. 1438-1447.
https://doi.org/10.1093/humrep/deh424

Research output: Contribution To Journal



Kirkman-Brown, JC, Barratt, CLR & Publicover, SJ 2004,

'Slow calcium oscillations in human spermatozoa' Biochemical Journal, vol. 378, no. Pt 3, pp. 827-32.
https://doi.org/10.1042/BJ20031368

Research output: Contribution To Journal



Lefièvre, L, Barratt, CLR, Harper, CV, Conner, SJ, Flesch, FM, Deeks, E, Moseley, FLC, Pixton, KL, Brewis, IA & Publicover, SJ 2004,

'Physiological and proteomic approaches to studying prefertilization events in the human' Reproductive biomedicine online, vol. 7, no. 4, pp. 419-27.
https://doi.org/10.1016/S1472-6483(10)61885-8

Research output: Contribution To Journal



Maher, ER, Afnan, M & Barratt, CL 2003,

'Epigenetic risks related to assisted reproductive technologies: epigenetics, imprinting, ART and icebergs?' Human Reproduction, vol. 18, no. 12, pp. 2508-2511.
https://doi.org/10.1093/humrep/deg486

Research output: Contribution To Journal



Kirkman-Brown, JC, Barratt, CLR & Publicover, SJ 2003,

'Nifedipine reveals the existence of two discrete components of the progesterone-induced [Ca2+]i transient in human spermatozoa' Developmental Biology, vol. 259, no. 1, pp. 71-82.
https://doi.org/10.1016/S0012-1606(03)00137-4

Research output: Contribution To Journal



Harper, CV, Kirkman-Brown, JC, Barratt, CLR & Publicover, SJ 2003,

'Encoding of progesterone stimulus intensity by intracellular [Ca2+] ([Ca2+]i) in human spermatozoa' Biochemical Journal, vol. 372, no. Pt 2, pp. 407-417.
https://doi.org/10.1042/BJ20021560

Research output: Contribution To Journal



Maher, ER, Brueton, LA, Bowdin, SC, Luharia, A, Cooper, W, Cole, TR, Macdonald, F, Sampson, JR, Barratt, CL, Reik, W & Hawkins, MM 2003,

'Beckwith-Wiedemann syndrome and assisted reproduction technology (ART)' Journal of Medical Genetics, vol. 40, no. 1, pp. 62-64.
https://doi.org/10.1136/jmg.40.1.62

Research output: Contribution To Journal



De Jonge, CJ & Barratt, CLR 2002,

'The future of reproductive cellular engineering in male infertility' Urologic Clinics of North America, vol. 29, no. 4, pp. 809-15.
https://doi.org/10.1016/S0094-0143(02)00077-0

Research output: Contribution To Journal



Kirkman-Brown, JC, Punt, EL, Barratt, CLR & Publicover, SJ 2002,

'Zona pellucida and progesterone-induced Ca2+ signaling and acrosome reaction in human spermatozoa' Journal of Andrology, vol. 23, no. 3, pp. 306-15.
https://doi.org/10.1002/j.1939-4640.2002.tb02232.x

Research output: Contribution To Journal



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