Professor Barratt is Head of Division Systems Medicine, Head of the Reproductive Medicine Group at the University of Dundee as well as a clinical scientist (Hon) with NHS Tayside. He graduated with an Honours degree in Zoology and then completed a Post Graduate Certificate in Education (University of Wales, Swansea). His PhD, also in Zoology, was under the supervision of Jack Cohen at the University of Birmingham.
His formative post-doctoral studies and ART experience was gained at the University of Sheffield [with Ian Cooke] where they specialized in natural cycle IVF. From 1997-2005 he was the Scientific Director of the ART Centre at the Birmingham Women’s Hospital.
Professor Barratt has been awarded a number of honors for outstanding contributions to the discipline e.g. Young Andrologist of the Year (American Andrology Society), the Professor Sir Robert Edwards keynote lecture at ESHRE.
He is a regularly invited speaker at national and international scientific conferences/workshops. He was a member of the WHO Male Fertility Semen Analysis Taskforce (for both the 4th and 5th editions) and director of the WHO (2012-2017) Male Fertility Expert Working Group which devised a new system for the diagnosis and treatment of the infertile male (https://academic.oup.com/humupd/article/23/6/660/3979420). He was a member of the Human Fertilisation and Embryology Authority for 6 years.
Professor Barratt has recently been appointed to editorial board of WHO for development of new Semen Analysis manual (6th edition).
He has been on the Editorial Board of Human Reproduction, Human Fertility, Biology of Reproduction, Human Reproduction Update, Journal of Andrology and is currently Editor-in-Chief of Molecular Human Reproduction (Impact factor 5 year 3.6)
His life’s ambition is to see - live - Wales comprehensively beat the All Blacks.
We are primarily focused on understanding the function of the human spermatozoa and identifying the key factors in the process of sperm egg interation.
Our research uses cutting edge technology combined with selected samples from patients with well-defined pathology. As such the research has a very strong translational focus. (http://www.acudundee.org/wp-content/uploads/2010/10/ATT04528.m4v)
Our primary collaborators in Dundee are the IVF clinic at NHS Tayside, Abertay University's Dr Sean Brown, Professor Paul Wyatt (Drug Discovery Unit, SLS), and Paul Andrews (National Phenotypic Screening Centre, SLS http://npsc.ac.uk/)
We regularly contribute to public debates on reproductive issues: e.g. impact of male age https://www.bionews.org.uk/page_135205
- Inventor: Barratt C (CMDN) & Wyatt PG (CLS) ‘Stimulation of human sperm motility’. International application number: PCT/GB2012/052514. Publication number WO/2013/054111. Publication date 18th April 2013.
- Inventor: Genosis & Barratt C ‘Method and detection kit for male infertility’ 1999. WO/99066331
Professor Barratt has supervised 29 MSc, PhD, MD students almost all of whom work in in the field of reproductive medicine.
His teaching consists of:
Supervisor: 9 MSc/PhD students
Leader: SSC in Stem Cells and Assisted Conception
External examiner (previous)
- Quinquennial Review MSc for ART at University of Oxford (2014).
- MSc for Reproductive and Developmental Biology at University of Edinburgh (2009-2013).
- United Arab Emirates Ministry of Higher Education and Scientific Research (2012-2013).
- 3rd year Reproductive Biology course at University of Edinburgh (2015-16).
- Endocrine and Reproduction Course (MDSC 2101) University West Indies 2014-2017.
- University of Nottingham (2004-2006).
- MSc in Embryology at the University of Leeds (2002-2004).
- MSc ART University of Bristol (2002-2005).
'Single-cell analysis of [Ca2+]i signalling in sub-fertile men: characteristics and relation to fertilization outcome' Human Reproduction, vol. 33, no. 6, pp. 1023-1033. DOI:
'Protect us from poor-quality medical research' Human Reproduction, vol. 33, no. 5, pp. 770-776. DOI:
'‘Man Up’: the importance and strategy for placing male reproductive health centre stage in the political and research agenda.' Human Reproduction, vol. 33, no. 4, pp. 541-545. DOI:
'People are very open-minded about new things, as long as they are exactly like the old ones' Molecular Human Reproduction, vol. 24, no. 1, pp. 1. DOI:
'Complex Cat Sper-dependent and independent [Ca2+] signaling induced by human follicular fluid' Human Reproduction, vol. 32, no. 10, pp. 1995-2006. DOI:
'The diagnosis of male infertility: an analysis of the evidence to support the developments of global WHO guidance. Challenges and future research opportunities' Human Reproduction Update, vol. 23, no. 6, pp. 660-680. DOI:
Current concepts and unresolved questions in human sperm cumulus and zona interaction. in The Sperm Cell: Production, Maturation, Fertilization, Regeneration. UNESCO/Cambridge University Press, pp. 152-156. DOI:
Preface. in The Sperm Cell: Production, Maturation, Fertilization, Regeneration. UNESCO/Cambridge University Press, pp. xiii. DOI:
'Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem' Human Reproduction, vol. 32, no. 5, pp. 974-984. DOI:
'Lessons in Andrology: Thoughts for a Young Andrologist' Andrology, vol. 4, no. 6, pp. 987-989. DOI:
'Preimplantation genetic screening-23 years to navigate and translate into the clinical arena. We need a new roadmap!' Molecular Human Reproduction, vol. 22, no. 8, pp. 837-838. DOI:
'Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF' Human Reproduction, vol. 31, no. 6, pp. 1147-1157. DOI:
''Single cell analysis in development' special series' Molecular Human Reproduction, vol. 22, no. 3, pp. 159. DOI:
'A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels' Human Reproduction, vol. 31, no. 2, pp. 287-297. DOI:
''How to count sperm properly': checklist for acceptability of studies based on human semen analysis' Human Reproduction, vol. 31, no. 2, pp. 227-232. DOI:
'Is there a robust future for research in reproduction?' Molecular Human Reproduction, vol. 22, no. 1, pp. 1-2. DOI:
'Specific loss of Cat Sper function is sufficient to compromise fertilizing capacity of human spermatozoa' Human Reproduction, vol. 30, no. 12, pp. 2737-2746. DOI:
'Clarification of scope for Human Reproduction and Molecular Human Reproduction' Human Reproduction Update, vol. 21, no. 5, pp. 559. DOI:
'Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection' Fertility and Sterility, vol. 104, no. 3, pp. 561-568.e4. DOI:
'Sperm selection in natural conception: what can we learn from Mother Nature to improve assisted reproduction outcomes?' Human Reproduction Update, vol. 21, no. 6, pp. 711-726. DOI:
'Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity' Human Reproduction, vol. 29, no. 10, pp. 2123-2135. DOI:
'Fertility preservation in men with cancer' Lancet, vol. 384, no. 9950, pp. 1295-1301. DOI:
'Importance of β-defensins in sperm function' Molecular Human Reproduction, vol. 20, no. 9, pp. 821-826. DOI:
'Patch clamp studies of human sperm under physiological ionic conditions reveal three functionally and pharmacologically distinct cation channels' Molecular Human Reproduction, vol. 20, no. 5, pp. 392-408. DOI:
'MHR celebration issue in tribute to Professor Sir Robert Edwards' Molecular Human Reproduction, vol. 19, no. 12, pp. 783-784. DOI:
'p,p'-DDE activates Cat Sper and compromises human sperm function at environmentally relevant concentrations' Human Reproduction, vol. 28, no. 12, pp. 3167-3177. DOI:
'Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice' PLo S Genetics, vol. 9, no. 10, e1003826, pp. 1-13. DOI:
'Intracellular translocation and differential accumulation of cell-penetrating peptides in bovine spermatozoa: evaluation of efficient delivery vectors that do not compromise human sperm motility' Human Reproduction, vol. 28, no. 7, pp. 1874-1889. DOI:
'The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation' Human Reproduction, vol. 28, no. 4, pp. 866-876. DOI:
'What should it take to describe a substance or product as 'sperm-safe'' Human Reproduction Update, vol. 19, no. SUPPL1, pp. i1-i45. DOI:
'Ca2+ signals generated by Cat Sper and Ca2+ stores regulate different behaviors in human sperm' Journal of Biological Chemistry, vol. 288, no. 9, pp. 6248-58. DOI:
'Proposal of guidelines for the appraisal of SEMen QUAlity studies (SEMQUA)' Human Reproduction, vol. 28, no. 1, pp. 10-21. DOI:
'Controlling how sperm swim: Ca2+signals, Ca2+stores and Ca2+channels' Human Reproduction, vol. 28, no. S1, pp. i20-i21. DOI:
'2-APB-potentiated channels amplify Cat Sper-induced Ca signals in human sperm' Biochemical Journal, vol. 448, no. 2, pp. 189-200. DOI:
'Chloride channels join the sperm 'channelome'' Journal of Physiology, vol. 590, no. 11, pp. 2553-2554. DOI:
'Sperm are promiscuous and Cat Sper is to blame...' EMBO Journal, vol. 31, no. 7, pp. 1624-1626. DOI:
'When and how should new technology be introduced into the IVF laboratory?' Human Reproduction, vol. 27, no. 2, pp. 303-313. DOI:
'ESHRE special interest group for andrology basic semen analysis course: a continued focus on accuracy, quality, efficiency and clinical relevance' Human Reproduction, vol. 26, no. 12, pp. 3207-3212. DOI:
'Absolute SILAC-compatible expression strain allows SUMO-2 copy number determination in clinical samples' Journal of Proteome Research, vol. 10, no. 10, pp. 4869-4875. DOI:
'Sperm motility: things are moving in the lab!' Molecular Human Reproduction, vol. 17, no. 8, pp. 453-456. DOI:
'The mystery is solved-Cat Sper is the principal calcium channel activated by progesterone in human spermatozoa' Asian Journal of Andrology, vol. 13, no. 3, pp. 351-352. DOI:
'Erratum - DPY19L2 Deletion as a Major Cause of Globozoospermia' American Journal of Human Genetics, vol. 88, no. 4, pp. 517. DOI:
'Reproductive biology: progesterone's gateway into sperm (vol 471, pg 313, 2011). Clarification' Nature, vol. 471, no. 7340, pp. 589-589. DOI:
'Reproductive biology: progesterone's gateway into sperm' Nature, vol. 471, no. 7338, pp. 313-314. DOI:
'DPY19L2 Deletion as a Major Cause of Globozoospermia' American Journal of Human Genetics, vol. 88, no. 2011, pp. 344-350. DOI:
'Diagnostic tools in male infertility-the question of sperm dysfunction' Asian Journal of Andrology, vol. 13, no. 1, pp. 53-58. DOI:
'DPY19L2, its mutation in about half globozoospermia' Human Reproduction, vol. 26, no. S1, P-412, pp. i281 . DOI:
'Human oocytes express ATP-sensitive K+ channels' Human Reproduction, vol. 25, no. 11, pp. 2774-2782. DOI:
'Clinical relevance of sperm DNA assessment: an update' Fertility and Sterility, vol. 94, no. 6, pp. 1958-1959. DOI:
'The every expanding sperm tool kit' Human Reproduction, vol. 25, no. Suppl.1, O-201, pp. i80-i80. DOI:
'Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications-a position report' Human Reproduction, vol. 25, no. 4, pp. 824-838. DOI:
'Male infertility joins the translational medicine revolution. Sperm DNA: from basic science to clinical reality' Molecular Human Reproduction, vol. 16, no. 1, pp. 1-2. DOI:
'Ca2+-stores in sperm: their identities and functions' Reproduction, vol. 138, pp. 425-437. DOI:
'Investigating infertility in primary care' Practitioner, vol. 253, no. 1716, pp. 26-28.
'Male obesity: impact on fertility' British Journal of Diabetes and Vascular Disease, vol. 9, no. 5, pp. 237-241. DOI:
'Communication between female tract and sperm: saying NO* when you mean yes' Communicative & Integrative Biology, vol. 2, no. 2, pp. 82-5.
'The human spermatozoon: a stripped down but refined machine' Journal of Biology, vol. 8, no. 7, pp. 63. DOI:
'Seminal white blood cells in men with urethral tract infection. A monoclonal antibody study' British Journal of Urology, vol. 68, no. 5, pp. 531-6.
'The human sperm proteome: the potential for new biomarkers of male fertility and a transformation in our understanding of the spermatozoon as a machine' Human Reproduction, vol. 23, no. 6, pp. 1240-1241. DOI:
'Mobilisation of stored calcium in the neck region of human sperm: a mechanism for regulation of flagellar activity' International Journal of Developmental Biology, vol. 52, no. 5-6, pp. 615-626. DOI:
'Mobilisation of Ca2+ stores and flagellar regulation in human sperm by S-nitrosylation: a role for NO synthesised in the female reproductive tract' Development, vol. 135, no. 22, pp. 3677-3686. DOI:
'Ca2+ signalling in the control of motility and guidance in mammalian sperm' Frontiers in Bioscience, vol. 13, 3105, pp. 5623-5637. DOI:
'Patch-clamp 'mapping' of ion channel activity in human sperm reveals regionalisation and co-localisation into mixed clusters' Journal of Cellular Physiology, vol. 213, no. 3, pp. 801-808. DOI:
'A survey of assisted reproductive technology births and imprinting disorders' Human Reproduction, vol. 22, no. 12, pp. 3237-3240. DOI:
'Human spermatozoa contain multiple targets for protein S-nitrosylation: An alternative mechanism of the modulation of sperm function by nitric oxide?' Proteomics, vol. 7, no. 17, pp. 3066-3084. DOI:
'Coordinated transcriptional regulation patterns associated with infertility phenotypes in men' Journal of Medical Genetics, vol. 44, no. 8, pp. 498-508. DOI:
'Counting sperm does not add up any more: time for a new equation?' Reproduction, vol. 133, no. 4, pp. 675-684. DOI:
'[Ca2+]i signalling in sperm--making the most of what you've got' Nature Cell Biology, vol. 9, no. 3, pp. 235-242. DOI:
'Patterns of [Ca2+](i) mobilization and cell response in human spermatozoa exposed to progesterone' Developmental Biology, vol. 302, no. 1, pp. 324-32. DOI:
'Understanding the physiology of pre-fertilisation events in the human spermatozoa--a necessary prerequisite to developing rational therapy' Society of Reproduction and Fertility Supplement, vol. 63, pp. 237-255.
'Is there a real risk of transmitting variant Creutzfeldt-Jakob disease by donor sperm insemination?' Reproductive biomedicine online, vol. 13, no. 6, pp. 778-790. DOI:
'Kinetics of the progesterone-induced acrosome reaction and its relation to intracellular calcium responses in individual human spermatozoa' Biology of Reproduction, vol. 75, no. 6, pp. 933-939. DOI:
'Characterization of cyclic adenine dinucleotide phosphate ribose levels in human spermatozoa' Fertility and Sterility, vol. 86, no. 4, pp. 891-8. DOI:
'Development of a novel home sperm test' Human Reproduction, vol. 21, no. 1, pp. 145-9. DOI:
'Calcium signalling in human spermatozoa: a specialized 'toolkit' of channels, transporters and stores' Human Reproduction Update, vol. 12, no. 3, pp. 253-67. DOI:
'The spermatozoon at fertilisation: current understanding and future research directions' Human Fertility, vol. 8, no. 4, pp. 241-251. DOI:
'Bicarbonate and bovine serum albumin reversibly 'switch' capacitation-induced events in human spermatozoa' Molecular Human Reproduction, vol. 11, no. 9, pp. 683-91. DOI:
'Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation' Molecular Human Reproduction, vol. 11, no. 7, pp. 523-529. DOI:
'Cracking the egg: increased complexity in the zona pellucida' Human Reproduction, vol. 20, no. 5, pp. 1148-1152. DOI:
'Secretory pathway Ca(2+)-ATPase (SPCA1) Ca(2)+ pumps, not SERCAs, regulate complex [Ca(2+)](i) signals in human spermatozoa' Journal of Cell Science, vol. 118, no. Pt 8, pp. 1673-85. DOI:
'The impact of mitochondrial genetics on male infertility' International Journal of Andrology, vol. 28, no. 2, pp. 65-73. DOI:
'Evaluation and treatment of familial globozoospermia in five brothers' Fertility and Sterility, vol. 82, no. 5, pp. 1436-1439. DOI:
'Stimulation of human spermatozoa with progesterone gradients to simulate approach to the oocyte. Induction of [Ca(2+)](i) oscillations and cyclical transitions in flagellar beating' Journal of Biological Chemistry, vol. 279, no. 44, pp. 46315-46325. DOI:
'Multi-state, 4-aminopyridine-sensitive ion channels in human spermatozoa' Developmental Biology, vol. 274, no. 2, pp. 308-17. DOI:
'Clinical challenges in providing embryos for stem-cell initiatives' Lancet, vol. 364, no. 9429, pp. 115-8. DOI:
'Four zona pellucida glycoproteins are expressed in the human' Human Reproduction, vol. 19, no. 7, pp. 1580-1586. DOI:
'Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: case report' Human Reproduction, vol. 19, no. 6, pp. 1438-1447. DOI:
'Slow calcium oscillations in human spermatozoa' Biochemical Journal, vol. 378, no. Pt 3, pp. 827-32. DOI:
'Physiological and proteomic approaches to studying prefertilization events in the human' Reproductive Bio Medicine Online, vol. 7, no. 4, pp. 419-27. DOI:
'Epigenetic risks related to assisted reproductive technologies: epigenetics, imprinting, ART and icebergs?' Human Reproduction, vol. 18, no. 12, pp. 2508-2511. DOI:
'Nifedipine reveals the existence of two discrete components of the progesterone-induced [Ca2+]i transient in human spermatozoa' Developmental Biology, vol. 259, no. 1, pp. 71-82. DOI:
'Encoding of progesterone stimulus intensity by intracellular [Ca2+] ([Ca2+]i) in human spermatozoa' Biochemical Journal, vol. 372, no. Pt 2, pp. 407-417. DOI:
'Beckwith-Wiedemann syndrome and assisted reproduction technology (ART)' Journal of Medical Genetics, vol. 40, no. 1, pp. 62-64. DOI:
'The future of reproductive cellular engineering in male infertility' Urologic Clinics of North America, vol. 29, no. 4, pp. 809-15. DOI:
'Zona pellucida and progesterone-induced Ca2+ signaling and acrosome reaction in human spermatozoa' Journal of Andrology, vol. 23, no. 3, pp. 306-15. DOI:
'ESHRE basic semen analysis courses 1995-1999: immediate beneficial effects of standardized training' Human Reproduction, vol. 17, no. 5, pp. 1299-1305. DOI:
'Inhibitors of receptor tyrosine kinases do not suppress progesterone-induced [Ca2+]i signalling in human spermatozoa' Molecular Human Reproduction, vol. 8, no. 4, pp. 326-332. DOI:
'Identification and localization of T-type voltage-operated calcium channel subunits in human male germ cells. Expression of multiple isoforms' Journal of Biological Chemistry, vol. 277, no. 10, pp. 8449-56. DOI: